Toddler Diagnosis?

[CatLady15]

My 2 year old son has been slow growing and gaining weight. At each of his standard check ups the pediatriation would hem and haw when she saw his percentiles come in. At his two year appointment, he was below 10% ile (originally around 45) for both hight and weight. Since he is a very good eater (I’m quite petite but dad is very tall) she referred us to a GI specialist. He has no remarkable GI symptoms. 
 

the GI specialist initially brushed me off but ran bloodwork. His results came back as:

everything normal except:

-TTG IGA weak positive (normal IGA level)
-slightly low hemoglobin and hemacrit
-deamidated Gliadin Peptide, IgG: weak positive
-AST high 

We proceeded with a endoscopy with biopsy which revealed “mildly increased intraepithelial lymphocytes” in the Duodenum and Duodenal bulb. 
 

Doc was not sure beyond “it could be celiacs or not” and had no further suggestions. I was frustrated since our first meeting 2.5 months prior he still had not grown any and had actually lost weight (now in the 3%ile) so she agreed to test him for the celiacs gene. Blood test confirmed positive for DQ2 gene that varies celiac. 

She suggested try gluten free for three months and re-test blood then. I am fine with this plan moving forward (for now) but curious if anyone has had similar test results, especially with someone so young (still not 2.5). 
 

he has been gluten-free for just over a month now and has already gained 2 lbs. Not sure if it is related. 

[trents]

Welcome to the forum, @CatLady15!

Your son's test results, both bloodwork and biopsy, are not uncommon for someone with celiac disease. The test results are not dramatic but they often aren't. The DQ2 gene is the strongest single gene marker indicating the potential for developing active celiac disease. AST is a liver enzyme. About 20% of celiacs have elevated liver enzymes. I was one of them and it was elevated liver enzymes that started me on the journey eventually leading to my celiac diagnosis over 20 years ago. 

This link might be helpful to you in achieving the gluten free diet for your son. It often involves a real learning curve:

 

[Scott Adams]

Your son has two positive blood tests for celiac disease, plus a positive biopsy for it...why hasn't your doctor diagnosed him with celiac disease, which is the most likely diagnosis based on the test results you shared? The next step should be a gluten-free diet, which your doctor already recommended.