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Asking for Help Understanding Endoscopy/Biopsy Lab Results


Sking

Recommended Posts

Sking Rookie

I just received my lab results from the endoscopy/biopsies to see if I have Celiac.

My doctor's office said it could take up to two weeks for the doctor to read the results and contact me to interpret them.

I am wondering if anyone can help me to understand my results?

On one hand, it seems like maybe I don't have it, but have something called Brunner Glands Hyperplasia, on the other hand it says I have increased lymphocytes and villous distortion. I am very confused. How will the doctor decide if I do or don't have it? I am so confused about all of this from the start of the journey a year ago, I really appreciate people's time on here reading this and helping me understand. Thank you.

 

Anatomic Pathology Report
Test Current Result and Flag Previous Result and Date Units Reference Interval
Diagnosis synopsis: 01
Part 1-Gastric ,Upper GI Polyp(s), Excision, Stomach:
PARIETAL CELL HYPERPLASIA IDENTIFIED. NEGATIVE FOR
DYSPLASIA.
Part 2-Duodenum ,Duodenum Biopsy: DUODENAL MUCOSA WITH NO
DIAGNOSTIC ABNORMALITIES. NO EVIDENCE OF CELIAC DISEASE.
NEGATIVE FOR GIARDIA, OTHER PARASITES OR OTHER PATHOGENIC
ORGANISMS. NEGATIVE FOR HELICOBACTER PYLORI. NEGATIVE FOR
DYSPLASIA OR MALIGNANCY.
Part 3-Bulb,Duodenum Biopsy: DUODENAL MUCOSA WITH INCREASED
INTRAEPITHELIAL LYMPHOCYTES AND VILLOUS DISTORTION. SEE
COMMENT.
Specimen: 01
Part 1-Gastric ,Upper GI Polyp(s), Excision, Stomach
Part 2-Duodenum ,Duodenum Biopsy
Part 3-Bulb,Duodenum Biopsy
Endoscopic findings: 01
Part 1-Polyp
Part 2-
Part 3-
Clinical diagnosis: 01
Part 1-
Part 2-R/O Celiac Sprue
Part 3-R/O Celiac Sprue
Diagnosis: 01
Part 1-PARIETAL CELL HYPERPLASIA IDENTIFIED. NEGATIVE FOR
DYSPLASIA.
Part 2-DUODENAL MUCOSA WITH NO DIAGNOSTIC ABNORMALITIES. NO
EVIDENCE OF CELIAC DISEASE. NEGATIVE FOR GIARDIA, OTHER
PARASITES OR OTHER PATHOGENIC ORGANISMS. NEGATIVE FOR
HELICOBACTER PYLORI. NEGATIVE FOR DYSPLASIA OR MALIGNANCY.
Part 3-DUODENAL MUCOSA WITH INCREASED INTRAEPITHELIAL
LYMPHOCYTES AND VILLOUS DISTORTION. SEE COMMENT.
Comment: 01
Part 1-
Part 2-
Part 3- Villous distortion could be due to Brunner glands
hyperplasia and not truly associated with celiac disease.
Please see the diagnosis of Jar 2. Recommend clinical
correlation.
Anatomic Pathology Report (Cont.)
Part 1-There is parietal cell hyperplasia with enlargement
and dilatation of the lumens of some oxyntic glands. No
dysplasia is seen.
Part 2-Duodenal mucosa shows preserved villous architecture
and normal cellularity of the lamina propria. Brunner
glands are identified. No gastric metaplasia is seen. No
dysplasia or malignancy is identified. There are no viral
inclusions. No Giardia, other parasites or other pathogenic
organisms are seen. No Helicobacter pylori organisms are
identified.
Part 3-Increased numbers of intraepithelial lymphocytes are
noted (>6 lymphocytes/20 enterocytes at villous tips).
Duodenal mucosa also shows villous distortion and slightly
increased cellularity of the lamina propria. Brunner glands
are hyperplastic.
Gross description: 01
Part 1-The specimen is received in formalin labeled "KING,
SHOSHANNA, Gastric Polyp ". Received are 2 fragments of
tan, soft, tissue measuring 0.4 x 0.3 x 0.1 cm to 0.3 x 0.2
x 0.1 cm. The specimen is submitted entirely in cassette 1.
Part 2-The specimen is received in formalin labeled "KING,
SHOSHANNA, Duodenum Bx ". Received are multiple fragments
of tan, soft, tissue measuring 0.5 x 0.2 x 0.2 cm to 0.1 x
0.1 x 0.1 cm. The specimen is submitted entirely in
cassettes 1-2. Minute fragment(s) may not survive
processing.
 


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trents Grand Master

IMO, Part 3 has some abnormalties that could indicate the early stages of celiac disease but the doctor is tentatively thinking not, at least at this point.

Sking Rookie

Thanks for taking a look. I also just did some research and saw that increased numbers of intraepithelial lymphocytes and villous distortion can possibly be from lymphocytic colitis (which I was diagnosed with this past summer)....so fingers crossed this is what she will say it is.

 

trents Grand Master

Well, I wouldn't rule either out. And you might consider trialing a gluten free diet for a few months to see if symptoms improve. That would tell you a lot. By the way, the incidence of other bowel diseases is higher in the celiac population than it is in the general population. And even if you don't have celiac disease, you could have NCGS. Gluten is just problematic for a lot of folks for various reasons.

Sking Rookie

So the strange thing is I don't have any symptoms at all, except the soft stools (comes and goes) which they told me was from the Lymphocytic colitis. I had some mild positives on my antibody test and one gene was positive which is what made my doctor go ahead with the endoscopy. The reason they started any of this was finding the lymphocytic colitis this past summer after I had C Diff and she said, Well....it may be from something like Celiac....

Definitely a lot to learn through all of this and I appreciate people like you taking the time to help out a stranger like me!

trents Grand Master
(edited)

Well, the only thing I would conclude with would be, if you choose not to trial the gluten free diet, is to encourage you to get periodically tested, either antibody blood tests or the biopsy or both. I think it something that needs to be monitored.

Edited by trents

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