Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

A Must Read:


trents

Recommended Posts

mle-ii Explorer

And guess what I ran across in a recent search of PubMed...

Open Original Shared Link

See my emphasis below in bold.

Microscopic colitis demonstrates a TH1 mucosal cytokine profile.Tagkalidis PP, Gibson P, Bhathal PS.

Royal Melbourne Hospital, Australia.

Background and aims: Microscopic colitis is an inflammatory disorder of unknown etiology. The aim was to characterize the mucosal cytokine profile of microscopic colitis with a view to understanding its potential pathogenic mechanisms. METHODS: Mucosal biopsies taken at flexible sigmoidoscopy from 18 patients (8 lymphocytic colitis and 10 collagenous colitis) were analyzed for cytokine profile using real time RT-PCR, in comparison to those from 13 aged-matched controls with diarrhoea-predominant irritable bowel syndrome. Biopsies from 6 patients with histologically documented remission were available for comparative analysis. Biopsies were also taken to determine the cellular expression of cytokine and cytokine-related proteins using immunohistochemistry. RESULTS: Mucosal mRNA levels were 100 times greater for interferon-gamma and interleukin-15, 60 times greater for tumor necrosis factor-alpha, and 35 times greater for inducible nitric oxide synthase in microscopic colitis compared to controls. Apart from a trend for elevated levels of interleukin 10, levels of other TH2 cytokines including interleukins 2 and 4 were too low to be accurately quantified. Mucosal interferon-gamma mRNA levels correlated with the degree of diarrhoea, and returned towards normal in remission. The immunohistochemical expression of cell junction proteins, E-cadherin and ZO-1, was reduced in active disease. No differences were noted between lymphocytic and collagenous colitis for any of the above parameters. CONCLUSIONS: MC demonstrates a TH1 mucosal cytokine profile with IFN-gamma as the predominantly up-regulated cytokine, with concurrent induction of nitric oxide synthase and down-regulation of interferon-fx-related cell junction proteins. This pattern is similar to that in coeliac disease and suggests it might represent a response to a luminal antigen.

Hmmmmm...

I have Microscopic Colitis (Lymphocytic to be more precise), this was determined during a colonoscopy. The standard blood tests I took found no celiac disease, yet there appears to be a link. Whether gluten is the cause in MC/LC who knows, in my case I'd bet quite a lot on that given that I have antibodies to gluten present in stool samples.

Make of it what you will. But someone explain to me how the colon showed inflamation, I show no anti bodies for gluten in my blood, yet I show antibodies in my stool. What is this? I'd call it a gluten allergy or intolerance.

Mike


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



andrew1234 Newbie

Racheal, JerseyGirl,

I think your points generally make sense and gluten intolerance would definitely be a candidate for research. Especially because there are many people on this board who claim to have seen a dramatic improvement when they went gluten free, and I think you can't ignore the experiences of so many people, even if it doesn't agree 100% with the things I learned in medical school, so what I am trying to say is that if you feel better than who am I to argue with that....

Also I realize that medical science doesn't know a 100% about the human body, probably not even 50%, so if something has not been proven yet doesn't mean it's not true.

ravenwoodglass Mentor
Racheal, JerseyGirl,

I think your points generally make sense and gluten intolerance would definitely be a candidate for research. Especially because there are many people on this board who claim to have seen a dramatic improvement when they went gluten free, and I think you can't ignore the experiences of so many people, even if it doesn't agree 100% with the things I learned in medical school, so what I am trying to say is that if you feel better than who am I to argue with that....

Also I realize that medical science doesn't know a 100% about the human body, probably not even 50%, so if something has not been proven yet doesn't mean it's not true.

Andrew you might want to consider looking into some of the research that has been done in Europe. You might also want to go into the NIH web site and take a look at some of their more recent findings. They are getting ready to launch a campaign to bring more celiac awareness to the doctors that are here in the US. There is a link to that site in the Publications section of the board. Also check out other celiac web sites you will find many stories similar to the ones here.

trents Grand Master

I think Andrew might have a valid point about the "intolerance" terminology. I read a book recently on food allergies/intolerances/sensitivities. The author had a section on the terminology related to pathlogic food reactions and she assigned "gluten sensitivity" to celiac disease. I think "gluten sensitivity" is a better handle than "gluent intolerance" for the reasons Andrew suggested. Having said that, it is true that words will have whatever meaning society assigns to them, whether by formal and intentional definition or by common usage. They have no intrinsic meaning.

Steve

Canadian Karen Community Regular
Racheal, JerseyGirl,

I think your points generally make sense and gluten intolerance would definitely be a candidate for research. Especially because there are many people on this board who claim to have seen a dramatic improvement when they went gluten free, and I think you can't ignore the experiences of so many people, even if it doesn't agree 100% with the things I learned in medical school, so what I am trying to say is that if you feel better than who am I to argue with that....

Also I realize that medical science doesn't know a 100% about the human body, probably not even 50%, so if something has not been proven yet doesn't mean it's not true.

We're just the tip of the iceberg........ ;)

I firmly believe that there are millions of people walking around with either celiac disease, gluten intolerance or gluten sensitivity and haven't a clue as to why there have all these different ailments that are unexplained.....

I also firmly believe that the current knowledge of celiac disease, gluten intolerance and gluten sensitivity is also just the tip of the iceberg. This is such an untapped source of possible explanation for a myriad of ailments, and the research has only begun to uncover it. I truely believe that within the next 5 - 10 years, there will be not only an explosion of diagnoses of gluten difficulties, but an explosion of research and breakthroughs....... That's my dream, and I'm sticking to it!!! :D

Karen

mle-ii Explorer

I agree, but I'd bet we'll also add casein and soy to that list as well. We'll see.

GravStars Contributor
This article is completely bogus. I am afraid this guy just wants to sell the "alpha program" to as many unsuspecting people as he can. First of all he states that the prevelance of celiac disease is 1% of the population. In fact research says that it's not higher than 1/250.

"In 1998, Alessio Fasano and colleagues tested blood samples from a blood bank to develop a reference point for the prevalence of celiac disease in the United States. They found that of 2,000 samples, 1 in 250 exhibited celiac-specific antibodies. In a much larger, nationwide prevalence study also led by Fasano (in which we participated), it was determined that of 13,000 participants, the rate of celiac disease in the healthy population exceeded 1 in 200. According to these projections, about 0.7 percent of the US population has celiac disease."

from: Open Original Shared Link

0.7 is pretty close to 1%, an easy round-up. maybe not entirely accurate, but not too far off.


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



rumbles Newbie

Intolerance vs. sensitivity:

Intolerance is the correct word. Intolerance refers to an inability. Sensitivity in medicine is often used to refer to the outcome and accuracy of test standards, as in a certain test has a high sensitivity rate. It often is also used for a symptom known as light sensitivity; normally a by product of certain ailments, it is a symptom often not of major focus in the medical community.

The people that call themselves gluten intolerant share some or many of the symptoms of those diagnosed with celiac disease or DH, with symptoms alleviated by the absence of gluten in the diet. Due to either negative test results, or having not undertaken testing for various personal reasons (including cost, insurability, etc.), they lack the diagnostic label celiac disease. These people and the gluten-related issues that they deal with should not be minimalized by trying to change their status from an inability to a sensitivity.

Many of us know how hard it is to get family and friends (and sometimes people in the medical community) to understand the significance of diagnosed celiac disease; imagine how hard it would be to convince others that you have a serious condition if it were called a sensitivity. Please save the word sensitivity for tests and toothpaste.

(A message to Andrew1234: thank you for understanding.)

trents Grand Master

Jersey girl,

You seem to be making a distinction between celiac disease and "gluten intolerance". I'm not sure I buy that. Perhaps you should explain what the difference is in your mind. I use these terms (though I prefer "gluten sensitivity" to "gluten intolerance") synonymously.

Although "sensitivity" may seem a little too milk toasty as a handle for our disease, I don't like "intolerance" because it suggests GI distress caused by an inability to break a food substance down. That is not the mechanism involved with celiac disease. I also note that the technical medical term most often used is "gluten sensitive entoropathy".

Steve

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      128,863
    • Most Online (within 30 mins)
      7,748

    Hb33
    Newest Member
    Hb33
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.1k
    • Total Posts
      71.3k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • Scott Adams
      Most likely cross-contamination I believe.
    • cristiana
      I think it takes different people different amounts of time, but in my own case I had pain,  bloating and loose stools for some time, exacerbated by a lactose intolerance, which eventually went.  I would say the really bad diarrhea got better quite quickly, but the bloating pain carried on for a few months, until I was told to give up lactose for a few weeks.  That helped enormously and once I realised milk and yoghurt was the cause, after a short break I went back to lactose very gradually and felt a lot better.  Now I can tolerate it well. From Coeliac UK "The enzyme lactase is found in the brush border of the small intestine. This is why people with coeliac disease can be deficient in lactase at diagnosis. Once established on a gluten free diet, the gut is able to heal and lactose digestion returns to normal. Lactose intolerance is therefore usually temporary." So if this helps your daughter, this doesn't mean you have to give up lactose forever, especially as dairy is such a good source of calcium for growing kids.   Bear in mind you should be able to reintroduce it. As for fatigue, this can be due to vitamin and mineral deficiencies,such as iron, vitamin D and B12.  Were these levels tested?  If not, I would suggest you get them done.  If your daughter is deficient in these, it is vital you address the deficiencies, and get the tests redone in a few months, particularly the iron, because too much can be dangerous.
    • knitty kitty
      Hello,   The medication in these inhalers can cause a thiamine deficiency if used by someone already low in thiamine.  We don't absorb sufficient amounts of vitamins and minerals due to the inflammation and damage done to our villi in Celiac Disease.  Even a long term strict gluten free diet may not provide sufficient amounts of vitamins and minerals.  There are eight B vitamins that all work together.  Thiamine deficiency often shows up first because our bodies use so much of it and it can't be stored very long. Thiamine deficiency symptoms can appear in as little as three days.  Without thiamine, the other B vitamins may not be able to function properly.   Thiamine is needed to clear lactic acid accumulation caused by the inhalers: Shoshin beriberi provoked by the inhalation of salbutamol https://pubmed.ncbi.nlm.nih.gov/12951730/    Significant Lactic Acidosis from Albuterol https://pmc.ncbi.nlm.nih.gov/articles/PMC5965110/ Albuterol-Induced Type B Lactic Acidosis: Not an Uncommon Finding https://pmc.ncbi.nlm.nih.gov/articles/PMC7263006/ Lessons of the month 1: Salbutamol induced lactic acidosis: clinically recognised but often forgotten https://pmc.ncbi.nlm.nih.gov/articles/PMC6964186/ An Overview of Type B Lactic Acidosis Due to Thiamine (B1) Deficiency https://pmc.ncbi.nlm.nih.gov/articles/PMC10731935/   Thiamine has antifungal and antibacterial properties.  Thiamine helps keep Candida in check.  Thiamine helps keep SIBO in check.  Thiamine helps with black mold, Aspergillis infection.  Riboflavin helps fight Candida infection in the mouth. Riboflavin Targets the Cellular Metabolic and Ribosomal Pathways of Candida albicans In Vitro and Exhibits Efficacy against Oropharyngeal Candidiasis https://pubmed.ncbi.nlm.nih.gov/36625571/   Thiamine deficiency can make ones voice hoarse and can cause localized edema.  Niacin deficiency can make ones voice hoarse.  (Niacin deficiency and Thiamine deficiency can each cause irritability, agitation, and lability.) Hoarseness in pellagra https://pubmed.ncbi.nlm.nih.gov/21507655/ Hidden Hunger: A Pellagra Case Report https://pmc.ncbi.nlm.nih.gov/articles/PMC8152714/   Anesthesia can cause B12 deficiency.  B12 deficiency can show up as mouth sores and geographic tongue, diarrhea, and dementia. Vitamin deficiency, a neglected risk factor for post-anesthesia complications: a systematic review https://pmc.ncbi.nlm.nih.gov/articles/PMC11823251/ Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency https://pubmed.ncbi.nlm.nih.gov/8250714/ Subacute combined degeneration of the spinal cord following nitrous oxide anesthesia: A systematic review of cases https://pubmed.ncbi.nlm.nih.gov/30144777/ The Effect of Vitamin B12 Infusion on Prevention of Nitrous Oxide-induced Homocysteine Increase: A Double-blind Randomized Controlled Trial https://pmc.ncbi.nlm.nih.gov/articles/PMC4052402/     Eating a diet that is heavy in carbohydrates can precipitate a thiamine deficiency.  As the amount of carbohydrates consumed increases, additional thiamine is needed, otherwise the carbs will be stored as fat.   Thiamine deficiency disorders: a clinical perspective https://pmc.ncbi.nlm.nih.gov/articles/PMC8451766/   Hiding in Plain Sight: Modern Thiamine Deficiency https://pmc.ncbi.nlm.nih.gov/articles/PMC8533683/   The deficiency symptoms of some of the B vitamins cause gastrointestinal symptoms that resemble the same symptoms as when being glutened.   Thiamine deficiency can present as vomiting, diarrhea and abdominal pain (Gastrointestinal Beriberi).  Niacin deficiency can present as diarrhea (Pellagra = diarrhea, dermatitis, dementia, then death ).  B12 deficiency can present as diarrhea or dementia.  Not everything is caused by hidden gluten.  Gluten free processed foods are not required to be enriched with vitamins lost in processing like gluten containing foods are. Blood tests are not accurate measurements of vitamin levels, but do talk to your doctor and nutritionist about supplementing with the eight B vitamins, Vitamin C, the four fat soluble vitamins and minerals like magnesium.  Your physician can give you a shot of B12 before anesthesia administration.   By the way, Celiac Disease genes have been traced back to having originated in Neanderthals.  I'm not a singing teacher on the net.  I earned a degree in Microbiology after studying nutrition because I wanted to know what vitamins are doing inside the body.  I've experienced nutritional deficiencies myself. Hope this helps!  Keep us posted on your progress!
    • trents
      Welcome to the forum, @jnstefan! She should start feeling better within a week or two if she is truly avoiding gluten and if she isn't also showing intolerance to other foods. It is quite common for celiacs to be dairy intolerant (not just the lactose but the protein casein in dairy) and to oats (protein is avenin). Casein and avenin have structures similar to gluten. We call this cross reactivity (not to be confused with cross contamination). So, you might look at pulling these two food items from her diet to see if there is improvement. But achieving a gluten free state is more challenging than people realize when the first start in. It is hidden in so many foods you would never expect to find it in like soy sauce and canned tomato soup, just to site two examples. This might help:  
    • jnstefan
      My 10 year old daughter was diagnosed with Celiac 2 weeks ago. We've been on gluten free diet now for 2 weeks. She still experiences abdominal pain at times , and is struggling with fatigue. What is everyone's experience with how long it takes for the body to heal and stabilize after starting the gluten free diet? Thanks for any feedback!
×
×
  • Create New...