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Genetic Origins Of Celiac


gfp

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gfp Enthusiast

All these threads on "Where do you come from" and trying to link that to celiac got me thinking.

Take any European country and it is non homogenious. There is no French gene pool or Italian gene pool... etc.

A Northern Italian is related much more closly with a Scandanavian than someone who's family have spent 1000 years inbreeding in Napoli but probably share the Scandanavian genes from Normans in Sicly,

So Someone saying they have Italian genes is just pointess. There is NO Italian gene... NO Irish gene ... etc. etc.

Scandanavian genes are somewhat purer if you ignore the Mongol and Slavic influence. (very few people wanted to invade the inhospitable North)

However this got me thinking... about from a European perspective pre-Roman gene pools.

Growing wheat or rye is a labour intensive task and one which is almost impossible to survive on without a community. Ever since 10 cavemen decided if they banded together and picked up sticks they could kill 100 individuals and steal their goats, women and whatever the "group" has become increasingly dominant in society.

(On top of this Scandanavian society is also rather different, the people are much more self reliant and traditionally prefer not to speak to anyone outside their immediate family and only then only if strictly necassary. Many West coast Norwegians would ideally like to live on their own mountain and see nooone (Xenophobes guide to Norwegians - written by a Norwegian) and if they ever do see anyone then they don't want to say much except "this is my mountain - go away you are in my personal space" Personal space in Norwegian terms means I can't see you or hear you.) or to put it bluntly Norwegians prefer to be alone.... and most of them still are living in communities of 100-200 ... scattered about.

Anyway....

It makes me think that the process of cultivating wheat is also linked to the ability to live in a community.

Up until the last 200 years in Europe it was completely possible to live outside of society.

People who didn't want to be a part of it had a whole load of possible paths. They could become hunters and only interect to trade or subsistance farmers in an isolated valley or charcola burners living in the woods and forests... etc. etc. ... in reality a whole set of traditional crafts that don't involve living in a town or villiage and only occaisionally having to interact with people.

These people were often regarded as "strange" .... the stuff of legends and kids tales. The witch in the woods or the lumberjack who chops up kids ... basically the stuff of the Grimm brothers or Hans Christian Andersen.

What if these were just people with a natural tendency against group mentality.

Back to the cavemen... and early pre-history!

You only need a few thousand people to wipe out a hundred thousand individuals.

People view the Roman invasion of Gaul as a mass of well disciplined Romans but in reality Julius had 3 legions.

A few thousand legionairres masacred hundreds of thousands of individual Celts.

The same thing crops up again and again in history ... a few thousand organised people either genociding completely or killing the males and taking the women of countless peoples.

Indeed we have now got to the point where "group mentality" is the norm and those who lack this are considered to be mentally deviant. I think the PC term is "Non Neurologically typical" but it means the same.

Each time the "NT group mentality" settled an area they planted wheat ....those who couldn't tolerate wheat died out with a higher rate being sickly, failing to conceive or miscarrying such that the original idea of small family groups became a minority in Europe and the only ones carrying on the non Group gene were the ones with limited social interaction living outside this society.


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queenofhearts Explorer

What a fascinating theory! And now I understand about those Norwegian batchelor farmers.

gfp Enthusiast
What a fascinating theory! And now I understand about those Norwegian batchelor farmers.

There is a whole lot of extra stuff I missed out.

If you see a traditional Norwegain costume Jewelry is very important.... the women folk needed to be able to take their wealth with them when the men folk went "a viking".

Vikings never built permanant villiages ... they used wood even when in many places wood was scarcer than stone.

The whole concept of viking was to provide more space for the sons to start families ... because the land and sea could only support low population densities. Whenever Vikings did build permanant cities it was usually in combination with the local farmers such as Celts in Ireland.

The Viking colony of Greenland died off mainly it is thought because they would not interact with the native inuit.

While Vikings starved the inuit survived with their traditional methods.

The starkest evidence of this is them eating their prized hunting dogs while we know contemporaneous Inuit's had no food shortages.

On the other hand genetic testing of a country shows that the average European person has little in common with someone form the other end of the country. Indeed there is less genetic diversity between an Australian aboriginal and a inuit (or any two far flung humans you can think of) than in a single troop of chimps.

Further the size of a chimp troop is genetically controlled.

Those from big troops will stay in big troops ... those from small ones stay as small groups.

If a big troop meets a small one they genocide it.

queenofhearts Explorer
There is a whole lot of extra stuff I missed out.

If you see a traditional Norwegain costume Jewelry is very important.... the women folk needed to be able to take their wealth with them when the men folk went "a viking".

I saw an exhibit at the Met years ago of Viking gold. It was astonishing-- the sheer bulk of gold-- I'd never seen anything like it. Interesting to know the reason behind it.

cgilsing Enthusiast

Wow that is interesting! I had always wondered why there was such a Celiac presence in Italy! I just googled it and read about the Norman invasion of southern Italy! Cool!

gfp Enthusiast
Wow that is interesting! I had always wondered why there was such a Celiac presence in Italy! I just googled it and read about the Norman invasion of southern Italy! Cool!

Thats not really what I'm saying....

Indeed the Vikings invaded most areas of looting and they were not exactly know for consentual sex with the locals.

The Longobards invaded Northern italy... and the goths and visigoths invaded right down to Rome.

but hardly before the Romans had already spread their DNA thoughout most of Europe and the Middle east and exchanged DNA with all of these cultures.

If you choose Italy (and its history is well documented so its a good bet) then follow the whole history from 10,000BC through to 1847.

Or Open Original Shared Link

that covers the basics of genetics on who we call Italian.

The celiac presence in Italy has only one reason, they screen all pre-school children.

The results of screening are EXACTLY the same as the US... 1:133 and this varies little throughout of most of Europe.

So

I am curious to know how Celiac's is related, in the majority, to people of an Irish background. Everyone I have spoken too, who have the disease, have some Irish background. I just want to know if there is a connection. If you have no Irish background, please let me know what nationalities you are.

Is meaningless..... possibly half of caucasian Americans claim some Irish background.

and of those that do not 1:25 children in the US are not the child of the presumed father.

I can trace part of my family tree back to 1219 ... that part is all "English" ... but the other parts all have everything from Irish, Jewish and possible Spanish... but stick me in Scandanavia and everyone is convinced I'm an (albeit short) typical Scandanvian. this is hardly suprising the Danish ruled the Nothern part of England for 400 years .. and even then they eventually met up and lost to the vikings in the south.

the battle of Hastings so often referred to as the last time the english were invaded is a farce, it was two vikings !

One who called himself English and the other who called himself Norman French...

queenofhearts Explorer

Just curious, are you a historian by profession, or do you study all this avocationally?


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cgilsing Enthusiast

Sorry to be off topic! I don't think I'm really awake yet! :P I'm going to ask a follow-up question though that's a bit off topic too...sorry but you seem to be knowledgable! So is the percentage of people with celiac disease the same in Northern Europe as well? Or is it higher? If not then how do they link celiac disease to Northern European decent?

gfp Enthusiast
Just curious, are you a historian by profession, or do you study all this avocationally?

:lol:

You missed the 50 questions thread! ;)

41. WHAT BOOK ARE YOU READING? I always read 4-5 books in parallel, Presently Tristram Shandy, Harry Potter (in French), Hugo Italian in 30 days (yeah right), Stephen hawkins " brief history of time" (toilet - gluten nights), Wilber Smith "the third prophet" in French.. don't know the exact title, Last chance to see Douglas Adams, Seutonius (latin and English versions concurrently), Voltaire, letters regarding the English nation (original English), Who dares Sells and Small business startup guide (work like), The Gallery, John Horne burns (very slowly because its a rere 1st ed. and this restricts me carying it around)

Cripes....

Actually I'm actually reading a couple more... a " Kafka for beginners" .. slowly making my way through the complete works of Dodgson... (and have been for a year) ...

meanwhile me thinks of a way to post a photo of "the Gallery" from the book which is in Naples and doesn't refer to my website.....(wouldn't want to break any more rules!)

methinks google images should do it! google Galleria napoli (but I bet my photo's are better)

Jestgar Rising Star

gfp,

I'm a little curious about where you get your genetic information from. We study the effect of SNPs (single nucleotide polymorphisms) on gene responses. There are huge differences in the SNP profiles of the different races, and people are beginning to investigate the profiles of same race populations from different locations.

If I look at one person's SNP profile from three genes, it;s possible that I can tell that this is a white individual with either asian or native american (same gene pool) influences. I can easily identify people who believe themselves to be all white but very likely have a not-to-distant african ancestor. And that's from three genes. We each have thousands of genes. I think it's very likely that every, even slightly inbred population is entirely different from one another.

Camille'sBigSister Newbie

Hi, gfp!

Very interesting concept! Have you read Arthur Koestler"s controversial but thought-provoking "The Thirteenth Tribe"? From the jacket: ". . . traces the history of the ancient Khazar Empire, a major but almost forgotten power in Eastern Europe, which in the Dark Ages became converted to Judaism. . . . ." Koestler provides extensive References and Bibliography sections. I don't know for sure, but imagine it's way out of print. I bought my hardback copy in the late 1970s or early 1980s.

I don't "get" Kafka, but maybe I'll try "Kafka for Beginners." :P

Just as an aside: During the Medieval Warm Period, farmers in Scandinavia were able to grow wheat at much more northern latitudes, and they grew oats at latitudes more northern still. About those Vikings in the Greenland settlement: Perhaps they would have survived, even after the seas froze and cut them off from the rest of the world during the onset of the Little Ice Age, were it not for the rigid mindset of their religion. They doomed their entire colony to death because they refused to associate with the "skralings" - the so-called heathen savages, whose survival skills in that frigid climate could have saved the Norse.

I have a friend in Paris whose parents were White Russians, who fled to Paris to escape the Bolsheviks. Her father, Sasha, was still alive when I met her, so I got to know him also. Sasha was fluent in 5 (or 7 - can't remember which) languages, and I drooled over his library! He would buy a book in all the languages of which he had command (provided that the book was available in those languages), because, as he explained, each language had its own nuances, and by putting them all together he got a complete picture of the author's intent.

I've enjoyed reading your perspective on the widespread prevalence of the celiac gene in Europe. :)

Cissie

(Definitely in the Non-NT category! :lol: )

gfp Enthusiast
gfp,

I'm a little curious about where you get your genetic information from. We study the effect of SNPs (single nucleotide polymorphisms) on gene responses. There are huge differences in the SNP profiles of the different races, and people are beginning to investigate the profiles of same race populations from different locations.

If I look at one person's SNP profile from three genes, it;s possible that I can tell that this is a white individual with either asian or native american (same gene pool) influences. I can easily identify people who believe themselves to be all white but very likely have a not-to-distant african ancestor. And that's from three genes. We each have thousands of genes. I think it's very likely that every, even slightly inbred population is entirely different from one another.

That is rather my point.

Part of this comes from looking into various haplotype markers (a while ago) and part of it comes from knowing a bit of history and a very large part comes from having worked with todays (or mostly yesterdays) military in 3rd world countries.

You can add other's bits of common knowledge... for instance the English (really meaning plantangenet) whilst invading Scotland made a law whereby the "English" lord had first rights on sleeping with a bride before she married... but even in normal circumstances the "Lord of the house" usually got first dibs on serving girls.....

Add this to the fact that even today 1:25 presumed named fathers on birth certificates are not the actual biological father. This has been happening for thousands of years ...

People for instance fail to realise that aincient Rome had a large Hindu trading population...

or the effect that Alexander had.... on gene mixing through the near east.

As far as scientists know, no particular genes make a person Irish or Chinese or Zulu or Navajo. These are cultural labels, not genetic ones. People in those populations are more likely to have some alleles in common, but no allele will be found in all members of one population and in no members of any other. (There may be rare variations, however, that are found only in some populations.) This cannot be very surprising, in light of the vast extent of intermarriage among human populations, now and throughout history and prehistory. There is no such thing as a genetically "pure" human population.

I got interested because I have a few Basque friends. However even though they are mainly recognisable by facial and physical characterists, premature balding pinning this down via genetics is pretty far off.

Another area of interest is for instance the spread of a certain religion.

If one takes a specific like the Iris goddess one can track its evolution through the mediterranean... from Minoan and phoenecian origins to deviations in Egypt or Carthage. Specific changes can be mapped and linked to trade..

The human genome project and HapMap being some resources (sorry trying to stick to the linking rule here)

Anyway.... One of the problems of studying history other than is that its written by winners is it extremely biassed. The English regard Napoleon rather poorly, the Napolese rather differently. When Napoleon invaded Napoli with his French army thousands of local girls would have traded genes either for fun, money or against their will... but its pretty much certain that they did! When the Germans occupied France the same and when the Americans were stationed in the UK during WWII a enormous amount of gene trading was taking place.

The idea of Romans occupying Gaul for some 500 years and not trading genes is pretty much laughable, not to mention many of the Romans were not genetically Roman at all anyway....

When you look at history from a particular place as opposed to the "country" way its taught at school then its rather obvious that a "proto-Italian" in sicly with carthaginian heritage is about as related to a Estrucian in Lazio as he is to a phoenecian, indeed his most direct link is through phoenicia.

Ghadaffi hosts the Africa for the Africans summit every year.... yeah sure the Arabs are indiginous?

Sorry... if that unspecific but if you ask a specific question (like origin of the goths) then I can answer that one specifically.

Jestgar Rising Star
Part of this comes from looking into various haplotype markers (a while ago)

People in those populations are more likely to have some alleles in common, but no allele will be found in all members of one population and in no members of any other.

Yes, but my point is, when looked at in combinations, there are very clear haplotype trails.

Here is link to an interesting article regarding human diversity.

Open Original Shared Link

CarlaB Enthusiast

Ugh, I wish the brain fog were lighter so I could follow this ... I look just like my father, so I'm one of the 24:25 ... 1/8 English at the very least. 1/8 French at least. The other 75%, who knows? I'll try to participate more in the intellectual aspects in a couple days ... I think I would have been more of a hunter/gatherer than a farmer, but I'm a very social type :) I know, I know, I'm waaayy out there ...

gfp Enthusiast
Hi, gfp!

Very interesting concept! Have you read Arthur Koestler"s controversial but thought-provoking "The Thirteenth Tribe"? From the jacket: ". . . traces the history of the ancient Khazar Empire, a major but almost forgotten power in Eastern Europe, which in the Dark Ages became converted to Judaism. . . . ." Koestler provides extensive References and Bibliography sections. I don't know for sure, but imagine it's way out of print. I bought my hardback copy in the late 1970s or early 1980s.

Not specifically but I am familiar with the Khazar's... most specifically from their role as allies to Constantinople. But also in reference to Jegstar's question....

The specific type (49a,f Haplotype 11) haplotype is thought to have been introduced eastwards prior to the rise of the Khazar nation but the same migration is also historically associated with patrimonial societies. The Khazar are meant to have had female leaders and advisors for instance and the association with art is seen in the decline of the mother goddess dominance to male godheads.

I don't "get" Kafka, but maybe I'll try "Kafka for Beginners." :P
That's why I'm reading it.... :D not that I can understand German anyway!

Just as an aside: During the Medieval Warm Period, farmers in Scandinavia were able to grow wheat at much more northern latitudes, and they grew oats at latitudes more northern still.

Yes and no... I don't think they relied on wheat.... and incidentally even today there is a particular area of fruit tree orchards along a specific Fjord. (Between Stavanger and Bergen and close to the temperate rain forest)

but not the way the Romans relied on grain....

About those Vikings in the Greenland settlement: Perhaps they would have survived, even after the seas froze and cut them off from the rest of the world during the onset of the Little Ice Age, were it not for the rigid mindset of their religion. They doomed their entire colony to death because they refused to associate with the "skralings" - the so-called heathen savages, whose survival skills in that frigid climate could have saved the Norse.
I was kinda trying to skip that part :D

I have a friend in Paris whose parents were White Russians, who fled to Paris to escape the Bolsheviks. Her father, Sasha, was still alive when I met her, so I got to know him also. Sasha was fluent in 5 (or 7 - can't remember which) languages, and I drooled over his library! He would buy a book in all the languages of which he had command (provided that the book was available in those languages), because, as he explained, each language had its own nuances, and by putting them all together he got a complete picture of the author's intent.
Quite a lot of them here still! .....I know quite a few :D

I've enjoyed reading your perspective on the widespread prevalence of the celiac gene in Europe. :)

Cissie

(Definitely in the Non-NT category! :lol: )

Thanks.... but its open to firther input, like you just did.

I literally just started typing... checked a few dates and stuff... so its a bit rambling....

mle-ii Explorer

Rather interesting stuff.

What I also found interesting that I learned about recently is that Irish Setters (the dog) are known to have Celiac. Supposedly this is what nearly brought them to extinction. The addition of wheat as a filler in dog food nearly brought them in.

I have no idea how this could possibly be related at all, but I did find it rather ironic with the talk of Irish genes and celiac. :)

Mike

debmidge Rising Star
the battle of Hastings so often referred to as the last time the english were invaded is a farce, it was two vikings !

One who called himself English and the other who called himself Norman French...

Who are these two Vikings?

I have a friend in Paris whose parents were White Russians, who fled to Paris to escape the Bolsheviks. Her father, Sasha, was still alive when I met her, so I got to know him also. Sasha was fluent in 5 (or 7 - can't remember which) languages, and I drooled over his library! He would buy a book in all the languages of which he had command (provided that the book was available in those languages), because, as he explained, each language had its own nuances, and by putting them all together he got a complete picture of the author's intent.

Cissie: Hi

Other than vodka with cream, what is a person who is a White Russian?

Deb

gfp Enthusiast
Yes, but my point is, when looked at in combinations, there are very clear haplotype trails.

Here is link to an interesting article regarding human diversity.

Open Original Shared Link

Yes, and I really appreciate you help in this (I know your busy now) ....

What I mean firstly is an "Italian genotype" doesn't exist. The genotype pools are much much smaller.

If you choose a single place and simply study the gene trading over 10,000 years then the influences are huge.

Language affinities vastly underestimate this because they only reflect dominant language pools with localisation and dialiectisation.

Back to my Italy example ... Italian has only been spoken in Napoli for a short time. Greek was up to this century the dominant language in Napoli.

Napolese (pretty much incomprehensible to anyone with Roman Italian) reflects French and Spanish (and I would expect the gene pool does equally, if such gene pools existed) but it also reflect the turkik side of the Austrian occupation mixed and hard to seperate from Arabic ... and perhaps traces of cartheginian influenced phoenecian.

Not to mention the influence of Byzantines, Lombards, Normans, Swabians, Angevins, Aragonese.

Napoli was a "greek" villiage before the Romans built Misineum ... but a single decision by Marcus Agrippa (one of the most under estimated architects of the Augustan era) changed this in ine fell swoop....

Historically Augustus' (great Nephew of Giaus Julius) needed to control piracy in the Tyrrhenian Sea. This had previously been ceded by Julius to Crassus as part of the agreement on the 1st triumvirate in order for his support to elect Julius to consul. so it was largely a political descision but one that altered the gene pool of Napoli enormously.

Unperterbed by the fact the area had no drinking water to support the fleet they built it..... and it soon became the largest port in the area and held the largest Roman fleet... quite what this meant so far as the brothels in Napoli and the genetic makeup of the fleet is enormous.

In some respects Napoli's gene pool is of course unique... but in other respects it is a complex mixing of hundreds of different cultural gene pools.

If you were to do this for nearby Ischia and Capri you would again find a different mix....

Capri is expensive and has been for 2000 years! During Roman times the gene pool was very different to Meseneum or Napoli.... you were either a serf or equestrian class to live in Capri.

You can look at different places all over Europe and the middle east in the same way.

York was where constantine (at least 50% serbian ) was crowned emporor.. but he made the seat of his empire Trier (now in Germany) as the Praefectus Praetorio Galliarium Trier was the administrative capital from Morocco to Britian. Once again this created a huge influx of "Roman's" from Spanish to Greek, before it was moved to Arles....

I'm drifting because the point is that I could then relate the history of Arles ... again unique and with an unique influx of genetic material and again creation of the aquaduct at Pont du Gard bringing in a unique gene pool of slaves....

Indeed the Gard area is quite distinct in many ways... from langue d'oc. Culturally and linguistically (grape varieties ... an area of interest for me and also a benificiary of DNA studies - especially at the Univerity of Montpellier halfway from Arles to Gard!), architecturally etc. etc. The architecture is .. well far more solid.. its what you would expect a master stone mason to build for himself... it wouldn't surprise me if we could find some genetic material of the original master masons preserved somewhere and actually trace that back to a component of the present day inhabitants.

Jestgar Rising Star

I love reading your posts.

On a different aspect of genetics, I recently watched a program on PBS that investigated the domestication of dogs and linked the development of coat colors and floppy ears to aggresion. I'll try to remember which program it was and see if there is a link on the web somewhere.

Jestgar Rising Star

Open Original Shared Link

This is about an experiment where a russian scientist selectively bred the least aggressive foxes. It's a great read.

"Their bodies changed in size and proportions, leading to the appearance of dwarf and giant breeds. The normal pattern of coat color that had evolved as camouflage in the wild altered as well. Many domesticated animals are piebald, completely lacking pigmentation in specific body areas. Hair turned wavy or curly, as it has done in Astrakhan sheep, poodles, domestic donkeys, horses, pigs, goats and even laboratory mice and guinea pigs. Some animals' hair also became longer (Angora type) or shorter (rex type).

Tails changed, too. Many breeds of dogs and pigs carry their tails curled up in a circle or semicircle. Some dogs, cats and sheep have short tails resulting from a decrease in the number of tail vertebrae. Ears became floppy. As Darwin noted in chapter 1 of On the Origin of Species, "not a single domestic animal can be named which has not in some country drooping ears" - a feature not found in any wild animal except the elephant.

queenofhearts Explorer

I love this thread! Fascinating stuff! Funny about the Irish setters-- though it makes sense that dogs in general wouldn't have evolved to digest wheat. It's odd really that they do as well as they do on the typical foods.

Camille'sBigSister Newbie
Who are these two Vikings? (End of your first quote.)

Cissie here. I'll give you a short answer, deb, and leave it to gfp to elaborate, if he wants to. Battle of Hastings, 1066 - William of Normandy defeated King Harold of England. This was one of history's most important dates, according to my high school history teacher. It's right up there with 1215, when King John signed the Magna Carta. I graduated from high school in 1951, in Memphis, Tennessee, and I still remember those historic dates in the history of English speaking people. :D

Cissie: Hi

Other than vodka with cream, what is a person who is a White Russian?

Deb

Hi, Deb!

Very brief synopsis: White Russia/Belorussia/Lithuania - a principality in the northwest, next to Poland on a map - under Russian control at time of the Socialist Revolution (1917) against the Tzar and his government; the Revolution was almost immediately afterward taken over by the radical Bolsheviks (Marxists/Communists). A counterrevolutionary movement arose, in 1918, to attempt to overthrow the Communist government; and the Russian Civil War began, lasting for years. For various, somewhat vague reasons, this counterrevolutionary army was called the White Army. It was composed of cossacks, army officers, the bourgeoisie, educated young men, and members of various political parties. Most intellectuals either joined the White Army, or gave it their support; thus they were called White Russians. (Think "Doctor Zhivago") The Red Army prevailed, as we well know, and wealthy, well-educated White Russians fled, mostly to Paris. French was the language of the Royal Court of Russia, and of all educated people. The White Russian father of my friend in Paris was definitely an intellectual.

As I said, this is a very brief synopsis. I hope it made sense.

Have a lovely weekend! :)

Cissie

eKatherine Rookie

In On Our Minds, Stephen Pinker discusses the heritability of many human personality traits that are generally considered to be acquired.

Clearly, if you breed animals for certain traits, other traits may become uncontrolled. So a dog bred for appearance may be vicious or stupid or nervous. Why is it considered that people are exempt from this? People often choose to marry partners who have similar personality traits, and if this is heritable, it is passed to the children more effectively than the effects of childrearing.

The book was very controversial, but after having read it, I'd have to say that most of the controversy seemed to be carried on by people who hadn't read the book.

CarlaB Enthusiast

Here's the article about Irish Setters.

Open Original Shared Link Advertisement/id23.html

GRRR. Instead of Lame Advertisement, put tripod dot com

gfp Enthusiast
Who are these two Vikings?

Harold Hadrara and Duke William (Guillaume) of Normandy

Harold is referred to as a "Saxon" but his mother was Gytha Thorkelsdóttir, said to be the granddaughter of the legendary Viking Styrbjörn Starke and great-granddaughter to Harold Bluetooth, king of Denmark and thus also ancestor to King Canute. (his predecessor and another Viking)

He married 2 Danes himself...So as you can see the idea of them being even Saxon is pretty messed up ...as he had far more Viking blood than saxon...

Rather interesting stuff.

What I also found interesting that I learned about recently is that Irish Setters (the dog) are known to have Celiac. Supposedly this is what nearly brought them to extinction. The addition of wheat as a filler in dog food nearly brought them in.

I have no idea how this could possibly be related at all, but I did find it rather ironic with the talk of Irish genes and celiac. :)

Mike

They are also quite strange dogs .... lovely but strange temperaments and many suffer mental conditions perhaps not so far from autism spectrum .... they can be quite intellegent and yet do the stupiest things .. forget what they are doing and joyfully start something else like running in circles for 30 mins...

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    • DayaInTheSun
      Interesting you mention MCAS. I have come across mcas before but I wasn’t entirely sure if that’s what it was. When I eat certain food like dairy or soy my face gets so hot and I feel flush and my heart rate shoot’s up. And sometimes my bottom lip swells or I get hives somewhere. This started happening after I had a really bad case of Covid.  Before that I was able to eat all those things (minus gluten) I was diagnosed with celiac way before I had Covid.  Hmm, not sure really. I may look for a different allergist my current one told me to take Zyrtec and gave me an epi pen. 
    • Kiwifruit
      This is all really useful information, thank you so much to you both.    I have a history of B12 and vit D deficiency which has always just been treated and then ignored until it’s now again.
    • trents
      Welcome to the forum, @Gill.brittany8! There are two main genes that have been identified as creating potential for developing celiac disease, HLDQ2 and HLDQ8. Your daughter has one of them. So, she possesses genetic the potential to develop celiac disease. About 40% of the general population carries one or both of these genes but only about 1% of the general population develops celiac disease. It takes both the genetic potential and some kind of triggering stress factor (e.g., a viral infection or another prolonged health problem or an environmental factor) to "turn on" the gene or genes. Unfortunately, your daughter's doctor ordered a very minimal celiac antibody panel, the tTG-IGA and total IGA. Total IGA is not even a test per celiac disease per se but is a check for IGA deficiency. If the person being checked for celiac disease is IGA deficient, then the scores for individual IGA tests (such as the tTG-IGA) will be abnormally low and false negatives can often be the result. However, your daughter's total IGA score shows she is not IGA deficient. You should consider asking our physician for a more complete celiac panel including DGP-IGA, TTG_IGG and DGP-IGG. If she had been avoiding gluten that can also create false negative test results as valid antibody testing requires having been consuming generous amounts of gluten for weeks leading up to the blood draw. Do you know if the GI doc who did the upper GI took biopsies of the duodenum and the duodenum bulb to check for the damage to the small bowel lining caused by celiac disease? Having said all that, her standard blood work shows evidence of possible celiac disease because of an elevated liver enzyme (Alkaline Phosphatase) and low values for hemoglobin.
    • Gill.brittany8
      Hi everyone  After years of stomach issues being ignored by doctors, my 9 y/o daughter finally had an upper endoscopy which showed a ton of stomach inflammation. The GI doctor ordered some bloodwork and I’m attaching the results here. Part will be from the CBC and the other is celiac specific. I’m not sure what’s relevant so I’m just including extra information just in case.   The results are confusing because they say “No serological evidence of celiac disease. tTG IgA may normalize in individuals with celiac disease who maintain a gluten-free diet. Consider HLA DQ2 and DQ8 testing to rule out celiac disease.” But just a few lines down, it says DQ2 positive. Can someone help make sense of this? Thanks so much.  result images here: https://ibb.co/WFkF0fm https://ibb.co/kHvX7pC https://ibb.co/crhYp2h https://ibb.co/fGYFygQ  
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