Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Lymphocytic/mycroscopic Colitis


Mary Contrary

Recommended Posts

Mary Contrary Rookie

After massive biopsies..{endoscopsy and colonoscopy] it has been determined this is what I have...and it rings true, I am like a text book case for this, but I have also been off of wheat for about 3 months, and two months prior to the tests....they said I am negative for celiac sprue..does anybody else have this autoimune disorder too ??? So I ate some cookies after they told me this..and nothing really happened, but I was a bit more gassy than usual a day or two later..I think I am staying off of wheat for the time being anyway..because I am finally getting almost back to normal.

does anybody else have this...Lymphocytic/Mycroscopic Colitis...it basically means you, sorry, crap yourself to death...constant non-bloody D.....but it does go away, mine is about stopped now for the last 3 weeks.

I have also read some other articles that say about a third of the people with this also have celiacs...

Open Original Shared Link


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Nancym Enthusiast

Dr. Fine has done a lot of research on this: Open Original Shared Link

How should Microscopic Colitis be treated?

I have studied the use of Pepto Bismol (Procter and Gamble) for the last 6 years and have achieved good results and learned a lot about the syndrome from these studies. However, although Pepto Bismol will relieve diarrhea in 90% and resolve the colitis on biopsies in about 80%, 20-30% experience relapses after they stop the medicine, and 10% do not respond initially. It has now become clear from extensive further research over the last 3-4 years that these relapses, and in the less common instances when there is no intitial response, have been shown by my new sensitive stool testing to be caused by coexisting immunologic sensitivity to gluten in the diet, that is to a protein found in wheat, barley, rye, and oats. Although not the cause of the colitis, per se, the reaction to gluten by the immune system can perpetuate or reactivate the colonic inflammation. Because of this chance of relapse, and because Pepto Bismol is still a drug with at least the potential (albeit rare chance) for side effects or reactions to the dyes, etc., I recommend testing for gluten sensitivity and a gluten-free diet as the first line of treatment for microscopic colitis. This appraoch has brought more relief to the sufferers of colitis than any other form of treatment to date. It must be stressed that because the reaction to gluten by microscopic colitis patients is usually not fully developed celiac disease, blood tests for antibodies to gliadin and tissue transglutaminase (the diagnositc tests for gluten sensitivity) are routinely negative. This is why and how I discovered that these antibodies must be looked for at the anatomic site of their production: inside the intestine, which for a diagnostic test, is in the stool. These tests are now available from EnteroLab for this purpose. This is discussed further below.

I think some of us, the ones that aren't super sensitive to gluten, won't have a full scale reaction to it immediately. Probably continued chronic exposure is going to set us right back to where we started from though.

It is enough to me to know that gluten is opening up those tight junctions in the gut and letting stuff escape into the blood stream that shouldn't be there. I don't need my immune system to get any more confused than it already is!

Mary Contrary Rookie

Oh thank you for that, well I firmly believe there is a direct connection..and also NOTHING brought me any relief except for adding Psyllium husk to my diet and getting off of wheat, and then it was over 2 months before things started to get better.

kara7 Rookie

I was diagonsied with Lymphocttic Colitis in Feb 05. My symptoms came back this summer but different and worse. Horrible blaoting and lots of other things. I was only seeing a colon/rectal surgeon who only wanted to put me on medication after medication. I am sick of being medicated and not finding an answer. I have an appointment next week with an allergists/immunologists since I have been getting hives for no explained reason. I also have a low B12. Do you have any of these other things along with your Lymphocytic Colitis.

Kara

Mary Contrary Rookie
I was diagonsied with Lymphocttic Colitis in Feb 05. My symptoms came back this summer but different and worse. Horrible blaoting and lots of other things. I was only seeing a colon/rectal surgeon who only wanted to put me on medication after medication. I am sick of being medicated and not finding an answer. I have an appointment next week with an allergists/immunologists since I have been getting hives for no explained reason. I also have a low B12. Do you have any of these other things along with your Lymphocytic Colitis.

Kara

no, so far I'm doing quite well now, I am hypothyroid, which is another autoimune disorder....

Try some Psyllium husks, I swear that is what is helping me the most..I take two heaping teaspoons in water with every meal, it is kinda like drinking sawdust, but who cares, it helps...I was going constantly to the bathroom, up at night too, and it was hell trying to work or do anything for months...now I am back to just once or twice in the morning, although it is still rather urgent, but nothing like it was.

Good luck to you I sure know how miserable this is....

happygirl Collaborator

Dr. Green discusses its association with Celiac in the book listed in my signature.

I was tested for it but do not have it. CanadianKaren on this board has it, also.

There is a great support forum at Open Original Shared Link that I would highly recommend.

Some people who have it are Celiacs, but some don't have "true" Celiac but still can't tolerate gluten. For them, it is often a combination of many food intolerances.

  • 3 months later...
Mary Contrary Rookie

I just thought I'd stop by, I haven't had any symptoms of the Lymphocytic/mycroscopic colitis for almost 3 months now, and I am eating wheat again, I have been for 6 weeks now, without one ill effect. I consider myself extremely lucky. When all of my problems were full blown I felt it was in my best interest to try everything humanly possible to get over my condition.

I sure did appreciate all of the help and advice I received from you good folks on this Forum.

I just wanted to stop by and bid you adieu. :)


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



corinne Apprentice

I, too, have collagenous (microscopic) colitis and I currently manage it with a gluten-free diet. I don't want to be a pessimist, but this type of colitis, like many others, usually follows an up-and-down course. It can disappear for weeks, months and sometimes years and then come back for a period of time. If it does come back, you may want to go back to gluten-free. Also check out the following board: Open Original Shared Link.

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      127,927
    • Most Online (within 30 mins)
      7,748

    DoraN
    Newest Member
    DoraN
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.5k

  • Celiac.com Sponsor (A22):




  • Who's Online (See full list)

    • There are no registered users currently online

  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • Scott Adams
      The first set of results show two positive results for celiac disease, so at the very least it looks like you could have it, or at the least NCGS.   Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.      
    • Scott Adams
      Elevated tissue transglutaminase IgA (tTG-IgA) levels are highly specific for celiac disease, and they are a key biomarker used in its diagnosis. However, there are some rare instances where elevated tTG-IgA levels have been reported in conditions other than celiac disease. While these cases are not common, they have been documented in the literature. Below are some examples and references to studies or reviews that discuss these scenarios:  1. Non-Celiac Gluten Sensitivity (NCGS)    - NCGS typically does not cause elevated tTG-IgA levels, as it is not an autoimmune condition. However, some individuals with NCGS may have mild elevations in tTG-IgA due to intestinal inflammation or other factors, though this is not well-documented in large studies.    - Reference: Catassi, C., et al. (2013). *Non-Celiac Gluten Sensitivity: The New Frontier of Gluten-Related Disorders*. Nutrients, 5(10), 3839–3853. [DOI:10.3390/nu5103839](https://doi.org/10.3390/nu5103839)  2. Autoimmune Diseases    - Elevated tTG-IgA levels have been reported in other autoimmune conditions, such as type 1 diabetes, autoimmune hepatitis, and systemic lupus erythematosus (SLE). This is thought to be due to cross-reactivity or polyautoimmunity.    - Reference: Sblattero, D., et al. (2000). *The Role of Anti-Tissue Transglutaminase in the Diagnosis and Management of Celiac Disease*. Autoimmunity Reviews, 1(3), 129–135. [DOI:10.1016/S1568-9972(01)00022-3](https://doi.org/10.1016/S1568-9972(01)00022-3)  3. Chronic Liver Disease    - Conditions like chronic hepatitis or cirrhosis can sometimes lead to elevated tTG-IgA levels, possibly due to increased intestinal permeability or immune dysregulation.    - Reference: Vecchi, M., et al. (2003). *High Prevalence of Celiac Disease in Patients with Chronic Liver Disease: A Role for Gluten-Free Diet?* Gastroenterology, 125(5), 1522–1523. [DOI:10.1016/j.gastro.2003.08.031](https://doi.org/10.1016/j.gastro.2003.08.031)  4. Inflammatory Bowel Disease (IBD)    - Some patients with Crohn’s disease or ulcerative colitis may have elevated tTG-IgA levels due to intestinal inflammation and damage, though this is not common.    - Reference: Walker-Smith, J. A., et al. (1990). *Celiac Disease and Inflammatory Bowel Disease*. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 389–391. [DOI:10.1097/00005176-199004000-00020](https://doi.org/10.1097/00005176-199004000-00020)  5. Infections and Parasites    - While infections (e.g., giardiasis) are more commonly associated with false-positive tTG-IgA results, chronic infections or parasitic infestations can sometimes lead to elevated levels due to mucosal damage.    - Reference: Rostami, K., et al. (1999). *The Role of Infections in Celiac Disease*. European Journal of Gastroenterology & Hepatology, 11(11), 1255–1258. [DOI:10.1097/00042737-199911000-00010](https://doi.org/10.1097/00042737-199911000-00010)  6. Cardiac Conditions    - Rarely, heart failure or severe cardiovascular disease has been associated with elevated tTG-IgA levels, possibly due to gut ischemia and increased intestinal permeability.    - Reference: Ludvigsson, J. F., et al. (2007). *Celiac Disease and Risk of Cardiovascular Disease: A Population-Based Cohort Study*. American Heart Journal, 153(6), 972–976. [DOI:10.1016/j.ahj.2007.03.019](https://doi.org/10.1016/j.ahj.2007.03.019)  Key Points: - Elevated tTG-IgA levels are highly specific for celiac disease, and in most cases, a positive result strongly suggests celiac disease. - Other conditions causing elevated tTG-IgA are rare and often accompanied by additional clinical findings. - If celiac disease is suspected, further testing (e.g., endoscopy with biopsy) is typically required for confirmation. If you’re looking for more specific studies, I recommend searching PubMed or other medical databases using terms like "elevated tTG-IgA non-celiac" or "tTG-IgA in non-celiac conditions." Let me know if you’d like help with that!
    • MaryMJ
      I called zero water and they state their filters do not contain gluten or gluten containing ingredients. 
    • trents
      I agree. Doesn't look like you have celiac disease. Your elevated DGP-IGG must be due to something else. And it was within normal at that after your gluten challenge so it is erratic and doesn't seem to be tied to gluten consumption.
    • Jack Common
      Hello! I want to share my situation. I had symptoms like some food intolerance, diarrhea, bloating, belching one year ago. I thought I could have celiac disease so I did the blood tests. The results were ambiguous for me so I saw the doctor and he said I needed to do tests to check whether I had any parasites as well. It turned out I had giardiasis. After treating it my symptoms didn't disappear immediately. And I decided to start a gluten free diet despite my doctor said I didn't have it. After some time symptoms disappeared but that time it wasn't unclear whether I'd had them because of eliminating gluten or that parasite. The symptoms for both are very similar. Giardiasis also damages the small intestine. The only way to check this was to start eating bread again as I thought. Now about my results.   These are my first test results (almost a year ago) when I had symptoms: The Tissue Transglutaminase IgA antibody - 0.5 U/ml (for the lab I did the tests 0.0 - 3.0 is normal) The Tissue Transglutaminase IgG antibody - 6.6 U/ml (for the lab I did the tests 0.0 - 3.0 is normal) Immunoglobulin A - 1.91 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) IgA Endomysial antibody (EMA) - < 1:10 titer (for the lab I did the tests < 1:10 titer is normal) IgG Endomysial antibody (EMA) - < 1:10 titer (for the lab I did the tests < 1:10 titer is normal) Deamidated gliadin peptide IgA - 0.3 U/ml (for the lab I did the tests 0.0 - 6.0 is normal) Deamidated gliadin peptide IgG - 46.1 U/ml (for the lab I did the tests 0.0 - 6.0 is normal)   Then I didn't eat gluten for six months. Symptoms disappeared. And I started a gluten challenge. Before the challenge I did some tests. My results: The Tissue Transglutaminase IgG antibody - 0.5 U/ml (for the lab I did the tests < 20 U/ml is normal)) Deamidated gliadin peptide IgG - 28 U/ml (for the lab I did the tests < 20 U/ml is normal)   During the challenge I ate 6 slices of wheat bread. After the challenge my results are: The Tissue Transglutaminase IgA antibody - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) The Tissue Transglutaminase IgG antibody - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) Immunoglobulin A - 1.31 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) Deamidated gliadin peptide IgA - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) Deamidated gliadin peptide IgG - 2.13 U/ml (for the lab I did the tests < 20 U/ml is normal)   To be sure I continued consuming gluten. I ate a lot each day. Two months after I did the tests again. My results I got today are: The Tissue Transglutaminase IgA antibody - 0.7 U/ml (for the lab I did the tests < 20 U/ml is normal) Immunoglobulin A - 1.62 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) Deamidated gliadin peptide IgG - 25.6 U/ml (for the lab I did the tests < 20 U/ml is normal)   Nowadays I didn't have any symptoms except tiredness but I think it's just work. I think it was this parasite because two years ago, for example, and before I didn't have these symptoms and I always ate gluten food. But I'm still not sure especially because the Deamidated gliadin peptide IgG results are sometimes high. What do you think? @Scott Adams
×
×
  • Create New...