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Got My Bloodwork Results

ElenaDragon

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ElenaDragon Explorer
ElenaDragon
Posted

My bloodwork came back negative, and I called my doctor's office to get the actual numbers. I am also being mailed the results.

IgG 0.7 (normal < 10)

IgA 2.9 (normal < 5)

tTG IgG 1.1 (normal < 9) - not positive this was IgG, the nurse was talking very fast

The problem I see is that before the test I really hadn't been eating much that has gluten in it. I was primarily eating oats and some rice for grains. I had even switched to rice crackers instead of wheat crackers. Occasionally I would have a sandwich when out. I'm sure there are small amounts of gluten in other things I ate, but it has not been a major daily component of my diet. I wasn't consciously trying to avoid gluten, instead I was just trying to stick to soluble fiber to help my IBS. But I'm concerned that this may have affected the test results.

Also, do doctors normally test for the celiac genes? It doesn't look like mine did. :angry:

I went gluten free starting yesterday because I think it's possible I could benefit from it. I really don't have much to lose, and if it doesn't help then at least I'll know that. The more I read about celiac, the more it seems to fit, but I don't know if that's just because I want it to or if I may actually have it. I have abdominal pain, gas, bloating, constipation, and diarrhea. I had my gallbladder removed due to gallstones when I was 19 (I'm 28 now). I get migraines and have Interstitial Cystitis (a bladder condition). I've already eliminated red meat, dairy, and soy from my diet, have been eating low fat and plenty of fiber (mainly soluble), but still having issues.

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Eriella Explorer
Eriella
Posted

Hello--

First of all, unless you were eating 4-6 slices of bread a day (or the equivalent) for 4 months or more, it is highly unlikely to test positive. So you could have celiac disease still. I would go 100% gluten free for 2 months, if your symptoms go away you have a gluten intolerance. You can do the genetic test at a later point to figure out if it is celiac or non-celiac gluten intolerance, or you could decide not to spend the money.

If you have any questions or support, just ask!

ElenaDragon Explorer
ElenaDragon
Posted
  • Author

Thank you, that sounds like very sound advice. I was definitely not eating that much bread (or the equivalent). Incidentally, I have a followup appointment with my GI in two months, so if I go gluten free, then perhaps I will have something to talk to her about by then. A diagnosis would be nice, but really what I want is to feel better. If the gluten-free diet does it for me, then wonderful!

Thanks!

ElenaDragon Explorer
ElenaDragon
Posted
  • Author

Okay, so I got the results in the mail and have them on paper now. The actual results are:

Gliadin IgG 0.7 (normal < 10)

Gliadin IgA 2.9 (normal < 2.9)

TTG IgG 1.1 (normal < 6)

TTG IgA 0.6 (normal < 4)

They seem pretty negative to me, but without eating a lot of bread beforehand, who knows. I wish my doctor had said something. She did ask if I had a problem with wheat or oats, and I said I ate oatmeal for breakfast every morning (plain rolled oats)... but from what I understand, oatmeal would only have traces of gluten due to cross contamination?

Also, at the bottom of the results, there is a note that says "An exclamation mark (!) indicates a result that was not dispersed into the flowsheet." They all have an exclamation mark next to them. Anyone know what that means?

confused Community Regular
confused
Posted
Okay, so I got the results in the mail and have them on paper now. The actual results are:

Gliadin IgG 0.7 (normal < 10)

Gliadin IgA 2.9 (normal < 2.9)

TTG IgG 1.1 (normal < 6)

TTG IgA 0.6 (normal < 4)

They seem pretty negative to me, but without eating a lot of bread beforehand, who knows. I wish my doctor had said something. She did ask if I had a problem with wheat or oats, and I said I ate oatmeal for breakfast every morning (plain rolled oats)... but from what I understand, oatmeal would only have traces of gluten due to cross contamination?

Also, at the bottom of the results, there is a note that says "An exclamation mark (!) indicates a result that was not dispersed into the flowsheet." They all have an exclamation mark next to them. Anyone know what that means?

I would think with your IGa being right at the normal,. that you were just not eating enough gluten at the time of the test. I would stay completely away from gluten and see if you feel better and if so then you know you have at least an gluten intolerance, if not celiac.

paula

ElenaDragon Explorer
ElenaDragon
Posted
  • Author

Oops, that was a typo. :unsure: The IgA should be: normal < 5.

confused Community Regular
confused
Posted

what you could also do, is do the gene testing threw enterolab for 149 bucks and see if you have the gene for celiac.

paula

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ElenaDragon Explorer
ElenaDragon
Posted
  • Author

Yeah I have thought about that. It's a lot of money though. I think I'm going to wait and see how the gluten-free trial goes first.

chrissy Collaborator
chrissy
Posted

according to your blood tests, and the fact that you said you had occasional gluten, i would think that your negative test results are probably right. it only takes a little bit of gluten to perpetuate the autoimmune response in a celiac. this does NOT mean that you are not having a problem with gluten, it just means you probably don't have celiac disease.

Guest Doll
Guest Doll
Posted
according to your blood tests, and the fact that you said you had occasional gluten, i would think that your negative test results are probably right. it only takes a little bit of gluten to perpetuate the autoimmune response in a celiac. this does NOT mean that you are not having a problem with gluten, it just means you probably don't have celiac disease.

I agree with Chrissy. That said, a percentage of Celiacs have negative bloodwork and a positive biopsy. If you are still eating oats, and you have not been off all other forms of gluten for very long, you likely would show some damage on the biopsy. If you want further "official" testing, it may be worth the biopsy. It's rare, but some people have Celiac without the typical Celiac genes.

If that checks out negative (assuming it was done correctly), then you likely do have non-Celiac gluten intolerance. I personally would just stick with the diet at that point. Or, if you don't want a biopsy, just stick with the diet now.

There really isn't enough published data to say that Enterolab is accurate, or worth the price. Of course, it is your choice.

P.S. Your doctor should have checked you EMA levels as part of a complete Celiac panel...

"IgA class anti-endomysial antibodies (AEA) are very specific, occurring only in celiac disease and DH. These antibodies are found in approximately 80% of patients with DH and in essentially 100% of patients with active celiac disease. IgA endomysial antibodies are more sensitive and specific than gliadin antibodies for diagnosis of celiac disease. Antibody titers (dilutions) are found to parallel morphological changes in the jejunum and can also be used to reflect compliance with gluten-free diets. Titers decrease or become negative in patients on gluten free diets and reappear upon gluten challenge."

ElenaDragon Explorer
ElenaDragon
Posted
  • Author

Thanks for the info. I think I'm going to go with the diet for now and see if I feel any better on it. I have another doctor appointment in two months, so I will talk with my doctor about the results of the diet then.

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    • Scott Adams
      How many grams is there in one slice of wheat bread?

      By Scott Adams · Posted

      The first set of results show two positive results for celiac disease, so at the very least it looks like you could have it, or at the least NCGS.   Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.      
    • Scott Adams
      Confused with test results

      By Scott Adams · Posted

      Elevated tissue transglutaminase IgA (tTG-IgA) levels are highly specific for celiac disease, and they are a key biomarker used in its diagnosis. However, there are some rare instances where elevated tTG-IgA levels have been reported in conditions other than celiac disease. While these cases are not common, they have been documented in the literature. Below are some examples and references to studies or reviews that discuss these scenarios:  1. Non-Celiac Gluten Sensitivity (NCGS)    - NCGS typically does not cause elevated tTG-IgA levels, as it is not an autoimmune condition. However, some individuals with NCGS may have mild elevations in tTG-IgA due to intestinal inflammation or other factors, though this is not well-documented in large studies.    - Reference: Catassi, C., et al. (2013). *Non-Celiac Gluten Sensitivity: The New Frontier of Gluten-Related Disorders*. Nutrients, 5(10), 3839–3853. [DOI:10.3390/nu5103839](https://doi.org/10.3390/nu5103839)  2. Autoimmune Diseases    - Elevated tTG-IgA levels have been reported in other autoimmune conditions, such as type 1 diabetes, autoimmune hepatitis, and systemic lupus erythematosus (SLE). This is thought to be due to cross-reactivity or polyautoimmunity.    - Reference: Sblattero, D., et al. (2000). *The Role of Anti-Tissue Transglutaminase in the Diagnosis and Management of Celiac Disease*. Autoimmunity Reviews, 1(3), 129–135. [DOI:10.1016/S1568-9972(01)00022-3](https://doi.org/10.1016/S1568-9972(01)00022-3)  3. Chronic Liver Disease    - Conditions like chronic hepatitis or cirrhosis can sometimes lead to elevated tTG-IgA levels, possibly due to increased intestinal permeability or immune dysregulation.    - Reference: Vecchi, M., et al. (2003). *High Prevalence of Celiac Disease in Patients with Chronic Liver Disease: A Role for Gluten-Free Diet?* Gastroenterology, 125(5), 1522–1523. [DOI:10.1016/j.gastro.2003.08.031](https://doi.org/10.1016/j.gastro.2003.08.031)  4. Inflammatory Bowel Disease (IBD)    - Some patients with Crohn’s disease or ulcerative colitis may have elevated tTG-IgA levels due to intestinal inflammation and damage, though this is not common.    - Reference: Walker-Smith, J. A., et al. (1990). *Celiac Disease and Inflammatory Bowel Disease*. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 389–391. [DOI:10.1097/00005176-199004000-00020](https://doi.org/10.1097/00005176-199004000-00020)  5. Infections and Parasites    - While infections (e.g., giardiasis) are more commonly associated with false-positive tTG-IgA results, chronic infections or parasitic infestations can sometimes lead to elevated levels due to mucosal damage.    - Reference: Rostami, K., et al. (1999). *The Role of Infections in Celiac Disease*. European Journal of Gastroenterology & Hepatology, 11(11), 1255–1258. [DOI:10.1097/00042737-199911000-00010](https://doi.org/10.1097/00042737-199911000-00010)  6. Cardiac Conditions    - Rarely, heart failure or severe cardiovascular disease has been associated with elevated tTG-IgA levels, possibly due to gut ischemia and increased intestinal permeability.    - Reference: Ludvigsson, J. F., et al. (2007). *Celiac Disease and Risk of Cardiovascular Disease: A Population-Based Cohort Study*. American Heart Journal, 153(6), 972–976. [DOI:10.1016/j.ahj.2007.03.019](https://doi.org/10.1016/j.ahj.2007.03.019)  Key Points: - Elevated tTG-IgA levels are highly specific for celiac disease, and in most cases, a positive result strongly suggests celiac disease. - Other conditions causing elevated tTG-IgA are rare and often accompanied by additional clinical findings. - If celiac disease is suspected, further testing (e.g., endoscopy with biopsy) is typically required for confirmation. If you’re looking for more specific studies, I recommend searching PubMed or other medical databases using terms like "elevated tTG-IgA non-celiac" or "tTG-IgA in non-celiac conditions." Let me know if you’d like help with that!
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    • trents
      What should I do with these test results?

      By trents · Posted

      I agree. Doesn't look like you have celiac disease. Your elevated DGP-IGG must be due to something else. And it was within normal at that after your gluten challenge so it is erratic and doesn't seem to be tied to gluten consumption.
    • Jack Common
      How many grams is there in one slice of wheat bread?

      By Jack Common · Posted

      Hello! I want to share my situation. I had symptoms like some food intolerance, diarrhea, bloating, belching one year ago. I thought I could have celiac disease so I did the blood tests. The results were ambiguous for me so I saw the doctor and he said I needed to do tests to check whether I had any parasites as well. It turned out I had giardiasis. After treating it my symptoms didn't disappear immediately. And I decided to start a gluten free diet despite my doctor said I didn't have it. After some time symptoms disappeared but that time it wasn't unclear whether I'd had them because of eliminating gluten or that parasite. The symptoms for both are very similar. Giardiasis also damages the small intestine. The only way to check this was to start eating bread again as I thought. Now about my results.   These are my first test results (almost a year ago) when I had symptoms: The Tissue Transglutaminase IgA antibody - 0.5 U/ml (for the lab I did the tests 0.0 - 3.0 is normal) The Tissue Transglutaminase IgG antibody - 6.6 U/ml (for the lab I did the tests 0.0 - 3.0 is normal) Immunoglobulin A - 1.91 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) IgA Endomysial antibody (EMA) - < 1:10 titer (for the lab I did the tests < 1:10 titer is normal) IgG Endomysial antibody (EMA) - < 1:10 titer (for the lab I did the tests < 1:10 titer is normal) Deamidated gliadin peptide IgA - 0.3 U/ml (for the lab I did the tests 0.0 - 6.0 is normal) Deamidated gliadin peptide IgG - 46.1 U/ml (for the lab I did the tests 0.0 - 6.0 is normal)   Then I didn't eat gluten for six months. Symptoms disappeared. And I started a gluten challenge. Before the challenge I did some tests. My results: The Tissue Transglutaminase IgG antibody - 0.5 U/ml (for the lab I did the tests < 20 U/ml is normal)) Deamidated gliadin peptide IgG - 28 U/ml (for the lab I did the tests < 20 U/ml is normal)   During the challenge I ate 6 slices of wheat bread. After the challenge my results are: The Tissue Transglutaminase IgA antibody - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) The Tissue Transglutaminase IgG antibody - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) Immunoglobulin A - 1.31 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) Deamidated gliadin peptide IgA - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) Deamidated gliadin peptide IgG - 2.13 U/ml (for the lab I did the tests < 20 U/ml is normal)   To be sure I continued consuming gluten. I ate a lot each day. Two months after I did the tests again. My results I got today are: The Tissue Transglutaminase IgA antibody - 0.7 U/ml (for the lab I did the tests < 20 U/ml is normal) Immunoglobulin A - 1.62 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) Deamidated gliadin peptide IgG - 25.6 U/ml (for the lab I did the tests < 20 U/ml is normal)   Nowadays I didn't have any symptoms except tiredness but I think it's just work. I think it was this parasite because two years ago, for example, and before I didn't have these symptoms and I always ate gluten food. But I'm still not sure especially because the Deamidated gliadin peptide IgG results are sometimes high. What do you think? @Scott Adams
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