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Immune Disease Runs In Families

SharonF

By SharonF
in Related Issues & Disorders

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SharonF Contributor
SharonF
Posted

2004 was a crazy year for my family. First I was diagnosed with celiac, then my mom with hypothyroidism, then my sister wtih hyPERthyroidism. My sister's doctor says that immune diseases can show up in different forms in families. This is fascinating to me.

Does anyone else have experience with different autoimmune diseases in your families?

I worry I'll pass something along to my kids.

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Janice C Newbie
Janice C
Posted

My sister has Type 1 diabetes. A cousin has celiac disease, and I suspect her brother does, too. Another cousin has Crohns. ( That looks misspelle.) I wonder if she is really a celiac.

Happycat Rookie
Happycat
Posted

I have hypothyroidism and chronic hives (5 months now), my son (12) has the thyroid antibodies and is on synthroid too. My 16 yr old has vitiligo, an autoimmune skin disease. My oldest son is gluten intolerant, he had positive blood IgG and tested positive with enterolab. Three of my 4 sons have thyroid antibodies. They have to be watched for Hashimotos thyroiditis.

The funny thing is neither of my parents or to our knowledge my grandparents have any autoimmune diseases! I don't know where it came from. The doctor said I inherited my lovely autoimmune diseases but I have no idea from who.

Lisa :blink:

MySuicidalTurtle Enthusiast
MySuicidalTurtle
Posted

Since you have Celiac Disease you can pass it on to your children.

My Mother, brother, and I all have Celiacs.

  • 2 weeks later...
poodlethree Rookie
poodlethree
Posted

I have Celiac and Hashimotos Throiditis. My son has Celiac. My mother has Crohns and my brother has Diabetes. We are not in the process of getting my daughter, sister and her daughter tested for Celiac. They all have symptoms and have had them for a while now.

I was told that Celiac is known to be passed on in families. Our family does seem to have quite a bit of autoimmune problems.

Hope this info helps.

Kathy B

KaitiUSA Enthusiast
KaitiUSA
Posted

I have celiac, my dad has thyroid issues along with my mom. My mom has a severe allergy to wheat but tested negative for celiac. Crohns runs in my dads family, thryoid disease runs in my moms family. My uncle, grandma, and 2 cousins we think need to get tested for celiac because they have alot of the symptoms.

I think that many people in my family have celiac, some are willing to get tested, others I don't think would really follow the diet correctly

I think it def. does run in families though

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      How many grams is there in one slice of wheat bread?

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      The first set of results show two positive results for celiac disease, so at the very least it looks like you could have it, or at the least NCGS.   Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.      
    • Scott Adams
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      Elevated tissue transglutaminase IgA (tTG-IgA) levels are highly specific for celiac disease, and they are a key biomarker used in its diagnosis. However, there are some rare instances where elevated tTG-IgA levels have been reported in conditions other than celiac disease. While these cases are not common, they have been documented in the literature. Below are some examples and references to studies or reviews that discuss these scenarios:  1. Non-Celiac Gluten Sensitivity (NCGS)    - NCGS typically does not cause elevated tTG-IgA levels, as it is not an autoimmune condition. However, some individuals with NCGS may have mild elevations in tTG-IgA due to intestinal inflammation or other factors, though this is not well-documented in large studies.    - Reference: Catassi, C., et al. (2013). *Non-Celiac Gluten Sensitivity: The New Frontier of Gluten-Related Disorders*. Nutrients, 5(10), 3839–3853. [DOI:10.3390/nu5103839](https://doi.org/10.3390/nu5103839)  2. Autoimmune Diseases    - Elevated tTG-IgA levels have been reported in other autoimmune conditions, such as type 1 diabetes, autoimmune hepatitis, and systemic lupus erythematosus (SLE). This is thought to be due to cross-reactivity or polyautoimmunity.    - Reference: Sblattero, D., et al. (2000). *The Role of Anti-Tissue Transglutaminase in the Diagnosis and Management of Celiac Disease*. Autoimmunity Reviews, 1(3), 129–135. [DOI:10.1016/S1568-9972(01)00022-3](https://doi.org/10.1016/S1568-9972(01)00022-3)  3. Chronic Liver Disease    - Conditions like chronic hepatitis or cirrhosis can sometimes lead to elevated tTG-IgA levels, possibly due to increased intestinal permeability or immune dysregulation.    - Reference: Vecchi, M., et al. (2003). *High Prevalence of Celiac Disease in Patients with Chronic Liver Disease: A Role for Gluten-Free Diet?* Gastroenterology, 125(5), 1522–1523. [DOI:10.1016/j.gastro.2003.08.031](https://doi.org/10.1016/j.gastro.2003.08.031)  4. Inflammatory Bowel Disease (IBD)    - Some patients with Crohn’s disease or ulcerative colitis may have elevated tTG-IgA levels due to intestinal inflammation and damage, though this is not common.    - Reference: Walker-Smith, J. A., et al. (1990). *Celiac Disease and Inflammatory Bowel Disease*. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 389–391. [DOI:10.1097/00005176-199004000-00020](https://doi.org/10.1097/00005176-199004000-00020)  5. Infections and Parasites    - While infections (e.g., giardiasis) are more commonly associated with false-positive tTG-IgA results, chronic infections or parasitic infestations can sometimes lead to elevated levels due to mucosal damage.    - Reference: Rostami, K., et al. (1999). *The Role of Infections in Celiac Disease*. European Journal of Gastroenterology & Hepatology, 11(11), 1255–1258. [DOI:10.1097/00042737-199911000-00010](https://doi.org/10.1097/00042737-199911000-00010)  6. Cardiac Conditions    - Rarely, heart failure or severe cardiovascular disease has been associated with elevated tTG-IgA levels, possibly due to gut ischemia and increased intestinal permeability.    - Reference: Ludvigsson, J. F., et al. (2007). *Celiac Disease and Risk of Cardiovascular Disease: A Population-Based Cohort Study*. American Heart Journal, 153(6), 972–976. [DOI:10.1016/j.ahj.2007.03.019](https://doi.org/10.1016/j.ahj.2007.03.019)  Key Points: - Elevated tTG-IgA levels are highly specific for celiac disease, and in most cases, a positive result strongly suggests celiac disease. - Other conditions causing elevated tTG-IgA are rare and often accompanied by additional clinical findings. - If celiac disease is suspected, further testing (e.g., endoscopy with biopsy) is typically required for confirmation. If you’re looking for more specific studies, I recommend searching PubMed or other medical databases using terms like "elevated tTG-IgA non-celiac" or "tTG-IgA in non-celiac conditions." Let me know if you’d like help with that!
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    • trents
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      By trents · Posted

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    • Jack Common
      How many grams is there in one slice of wheat bread?

      By Jack Common · Posted

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