Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Alvine Pharmaceuticals Reports Positive Results


patriceo15

Recommended Posts

patriceo15 Rookie

Found this today So I wanted to share with all of you.

Open Original Shared Link


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



darlindeb25 Collaborator

I had read this earlier and I think it's wonderful for accidental glutenings. I however, do not feel it's safe for a celiac/gluten intolerant to feel it's ok to use this type of med and then go ahead and eat gluten. We will never beable to safely eat gluten. There is much testing to be done to prove this type of product...years and years, in my opinion.

ShayFL Enthusiast

I personally will never take a drug when a healthy dietary change cures me. All drugs have side effects and some arent known for years and can be horrible (liver failure, heart failure, etc.) Why on Earth would I take something that could ultimately destroy my health when living gluten-free is very doable and healthy?

happygirl Collaborator

Thanks for sharing this, patrice. Great to see research being done on Celiac.

Puddy Explorer

Thanks, Patrice. This sounds like good news to me!

ENF Enthusiast

It's great news for those of us who would like protection against cross-contamination. Many people with Celiac will want it, even if just for eating out in restaurants or at someone else's house. Bring it on!

Gemini Experienced
Found this today So I wanted to share with all of you.

Open Original Shared Link

The outcome of the Phase 1 Trial of ALV003 is a major step toward providing people with celiac disease a better quality of life, as there are currently no approved pharmaceutical therapies available," said Dr. Ciaran P. Kelly, Medical Director of the Celiac Center at Beth Israel Deaconess Medical Center and Harvard Medical School. "Given the difficulty of following a strict gluten free diet, and the potentially serious health consequences of gluten exposure, there is a great medical need for ALV003 and other new therapies targeting celiac disease."

As much as I think this or any drug would be useful for travellers who want to protect themselves against CC in a foreign country, this statement makes me cringe.

I have wonderful quality of life, as far as food goes and certainly do not need any pharmaceutical therapies, i.e. DRUGS, to make my life better on a daily basis.

We have become such a pill popping nation that most ignore bad eating habits and inactivity and run to a doctor to get a pill for everything. I'm waiting for a pill that breathes for you so you won't have to waste a muscle contraction and the resultant energy it would require. :P No wonder Type 2 diabetes is at epidemic levels!

The diet is also NOT difficult, either. With doctor's going around with that attitude, no wonder people cannot accept a diagnosis and continue to cheat and make themselves sick. I am glad there may be a pill to protect you while travelling but as for use on a daily basis, NOT!


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      127,509
    • Most Online (within 30 mins)
      7,748

    Mr-Collateral531
    Newest Member
    Mr-Collateral531
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.2k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • knitty kitty
      Welcome to the forum, @robingfellow and @Mr-Collateral531, I also had to have my gallbladder removed in emergency surgery.  The gallbladder uses lots of thiamine vitamin b1 to function.   The gallbladder cannot secrete bile if it doesn't have sufficient thiamine.  Thiamine provides our muscles and glands energy to move and secrete needed enzymes and hormones.  The thyroid is another gland that requires lots if thiamine to function and secrete hormones.   Our brains, just thinking at a desk job, requires as much thiamine as our muscles do if running a marathon.   Migraines are linked to thiamine deficiency. Thiamine is the first of the eight B vitamins that our body needs. Thiamine can only be stored for three weeks at most.  Our thiamine stores can be depleted in as little as three days.  We need more thiamine when we have a physical injury (like recovering from surgery or fighting the flu), if we're emotionally stressed or traumatized, and if we're physically active.  Thiamine, like the other B vitamins, is water soluble and easily excreted in urine or most in diarrhea.  B vitamins are commonly poorly absorbed in Celiac Disease.  Thiamine and the other B vitamins need to be taken together because they interact with each other to make life sustaining enzymes.  Thiamine deficiency can affect individual organs.  Gallbladder dysfunction is connected to thiamine deficiency, as is hypothyroidism.    Migraines are connected to thiamine deficiency.  Gastrointestinal Beriberi (abdominal pain, vomiting, etc.) is a result of thiamine deficiency.  Tachycardia and fatigue are also symptoms of thiamine deficiency.   Thiamine and magnesium make enzymes that are essential for life.   Thiamine is needed to absorb certain minerals like iron.  Anemia and thiamine deficiency frequently occur together.  Thiamine deficiency can cause poor blood cell production (including low antibody production).   Thiamine interacts with other vitamins and minerals.  Vitamin D is not utilized by the body until turned into an active form by Thiamine. Thiamine is safe and nontoxic even in high doses.  High doses of thiamine correct deficiencies quickly which prevent further health deterioration.  A one a day type multivitamin is not sufficient to correct vitamin and mineral deficiencies that occur in the malabsorption of Celiac Disease.   The Gluten free diet is low in vitamins as they are not required to be enriched with vitamins lost in processing.  Supplementing with thiamine and the B vitamins boosts their absorption.   Helpful Reading: Hiding in Plain Sight: Modern Thiamine Deficiency https://pmc.ncbi.nlm.nih.gov/articles/PMC8533683/ Gastrointestinal Beriberi and Wernicke's Encephalopathy Triggered by One Session of Heavy Drinking https://pmc.ncbi.nlm.nih.gov/articles/PMC6739701/ P. S. Try a DNA test to see if you have any known genes for Celiac Disease before doing a gluten challenge.
    • Matt13
      Thanks for the reply ! I am asking because tomorow i have egd and nobody told me not to eat gluten-free oats… and i was scared that it could ruin my biopsy results… 
    • trents
      Yes, I would think that for the 10% of celiacs who can't tolerate oats it would cause villous atrophy just like gluten. No, it would not produce marsh 3b villous atrophy in a couple of days. Nothing will produce measurable villous atrophy that fast. It takes at least two weeks of at least 10g of gluten consumption daily (10g is the amount found in about 4-6 slices of wheat bread) to develop measurable villous atrophy and even then probably not 3b villous atrophy. Are you asking these questions in because you are considering taking on a gluten challenge?
    • Matt13
      Thanks for the awnsers i understand there is maybe system reaction but do they create or cause villious atrophy? And igmf you it them for example a couple of days di they instantly induce marsh 3b?
    • robingfellow
      My gallbladder was at 94% ejection fraction according to my HIDA scan before surgery, when the "normal" range is considered to be between 30-80%, so the surgeon recommended removal because I had been experiencing severe chronic upper quadrant pain and even vomiting despite having a strong stomach. A biopsy after surgery showed intense inflammation suggesting my gallbladder was on the verge of bursting if I hadn't gotten it removed.   The last time my iron and vitamin d levels were checked post-gluten free diet they were in a normal range (I take 60mg iron tablets every other day, and vitamin D capsules daily) I do also take magnesium daily, specifically 400mg magnesium bisglycinate at night to aid my sleep since I try to avoid taking melatonin due to personal preference.   I'll definitely have to keep in mind the point about celiac possibly causing gallbladder problems, I'll probably wait until I can see a proper GI and get their input before I attempt to reintroduce gluten back into my diet that way any reaction I may or may not have can be properly assessed.
×
×
  • Create New...