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Another Pill Possibility


celiac3270

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celiac3270 Collaborator

Another possibilitiy for that miracle pill--for celiac and diabetes:

Open Original Shared Link


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Carriefaith Enthusiast

2006! wow that's soon

Thanks for the link :)

MySuicidalTurtle Enthusiast

""The only real reservation is that it's only been tested in rats," Dr Anderson said. "Rats don't suffer coeliac disease. But it's a major development and it's important work.""

I was wondering that.

celiac3270 Collaborator

I know....so soon if it actually worked. Two sad things, though:

  • We'd be relying on a pill when we could feel fine through dietary restriction and no drugs.
  • Boards such as this one, though not becoming obsolete, would be less popular, since people could just pop pills....and we wouldn't make all the friends that we have on here :)

Carriefaith Enthusiast

When I really think about it, I really can't see a pill coming out that soon. Maybe 8-10 years I mean if the test animals (rats) don't get celiac disease then how can it work on humans? I think there is going to be a lot of trial and error. I'm sure the researchers are doing a good job but I am skeptical.

red345 Apprentice

Thanks for the link, buddy. Great work, and that's exciting news, isn't it.

The interesting part of this is that if I've learned anything at all, it has been to recognize that the concepts promoted here are probably the best type of suggestions that you could ever act on for the benefits of your own health. And for whatever reason, I believe this only the marks the beginning.

Mr. Adams and all of excellent specialists that have contributed to this website are only beginning to unlock the door to something I believe may just be the main mystery behind just about everything having to do with our health.

So whether or not a cure is ever found, or that magic pill is invented, etc, it would certainly come as wonderful news for everyone here. To take away those major concerns is something that everybody would like to see happen, afterall.

However, I also tend to believe this diet is something everybody should consider if they want to remain healthy in the long run, I really do. Infection or not, DQ2 gene or not, it would definitely seem to me that consuming these types of foods would be better for you than loading up on those crispey cremes like everybody else does, you know?

We're always going to consume sugar, you can't get away from that. But the key is to approach that with some moderation, and I think that your odds are better to keep yourself in check on that end if you stick to many of the concepts involved with this diet. In the long run, I believe that all of you will come out of this with better health than the rest of society, I really do.

I also think we're only getting into the heart of it with this. That said, this place is only going to get more popular, and it'll be that way for a very long time to come. If there is any medical condition that explains for more of the unsolved mysteries that we find today, it would appear that it all starts right here, and that is why all of you that stop by celiac.com should write down the website and pass it onto as many people as you can.

Whether or not I'm right about any of my personal beliefs, I don't know that answer. But what I do know is that one way or the other, it all seems to start right here. Let me just say that if Adams was offering IPO's into his website, I'd buy them all up overnight~. The effort he has made to bring attention to this disease has really come as a Blessing to so many. He, along with the wonderful specialists that have contributed to this site, have done a lot more for people than a hospital full of other doctors could ever do, that much is for sure.

Happy to see that you're coming along well after surgery, buddy. I bet mom's breathing some sighs of relief that her little pal is gonna be a lot better very soon, isn't she. Take care.

tarnalberry Community Regular

I saw this take on it on LJ; seems people have started touting this as a cure for celiac and diabetes after a few weeks of the articles circulating, and it seems like we've got nothing than a game of "telephone" gone wrong.

Here's the original study abstract with reference to diabetes: Open Original Shared Link and here is the original abstract discovering its role in celiac: Open Original Shared Link and here is the press release from the work Dr. Fasano's doneOpen Original Shared Link

They've tested it in rats for trying to prevent T1 diabetes. The immune reaction of celiac disease occurs _in_ the intestines, so mediating a chemical that prevents things from getting _outside_ the intestines could help deal with some things, but it's not dealing with the full set of chemical reactions that cause the damage.

I'm not saying that this isn't good news, I just don't want people to get their hopes up that they'll definitely be eating bagels again in four or five years.


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MySuicidalTurtle Enthusiast

I was thining, what about other reactions?

I know reac to gluten touching my kin for long periods of time and sometimes get rashes. How is this pill going to stop that?

I know I will never knowingly eat gluten even with a pill.

plantime Contributor

I'm not seeing where this will cure celiac. I do see where it will cure many food allergies, the ones that manifest in symptoms other than anaphlylaxia. For example, it could allow me to eat eggs without getting the horrific migraines. But I do not see where stopping the gut permeability problem will allow my body to digest gluten. The gluten will remain undigested, my body will continue to attack it, and my small intestine will be wiped out. I will still have celiac.

jknnej Collaborator

Good luck finding humans with celiac disease to test this pill! LOL

No one would eat gluten on purpose, not even for the hope of a cure..too bad.

Red is right, anyway; we are MUCH healthier.

Since I stopped eating out (because I'm afraid of cross contamination) I have energy again like I haven't in years. And no tummy aches.

I don't ever want to go back. Yes, I miss those foods horribly but the trade off is how I feel. Everytime I think of a Jack and the Box Ultimate Cheeseburger I just think of the horrible tummy ache I get after eating it! 5 minutes of pleasure just isn't worth a week of pain!

celiac3270 Collaborator

I agree--there's no way I would intentionally eat gluten at this point--even for the sake of other celiacs who may be hoping for a cure.

I'm skeptical--we've heard things like this in years past that never ended up working. Besides which, we're better off not eating all the food we were before.

Additionally, Dr. Green, in a radio segment awhile ago, made some comment how he estimates that about a decade from now there will be a pill that will reduce/ameliorate the reactions celiacs have to gluten accidents--he didn't seem to think a cure would be coming anytime soon.

I agree also in that I wouldn't want to go back to eating gluten, either. Though I think there's no way we'd convince future celiacs who would just want their bagles back and not realize how much healthier this is.

ianm Apprentice

I know a few diabetics who would rather pump themselves full of insulin than change their eating and lifestyle habits. For us celiac disease'ers the only solution is to stop eating gluten and live healthier lifestyles. Even if a pill was available I prefer to live the lifestyle I am living know. A pill would be good for those that are extra sensitive to gluten and have serious reactions to it. Something to keep the reaction from being as bad as it normally would be when accidentally glutened. Being able to take a pill so I can eat junk food and not exercise just isn't the right way to go.

Ianm

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    • Scott Adams
      The first set of results show two positive results for celiac disease, so at the very least it looks like you could have it, or at the least NCGS.   Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.      
    • Scott Adams
      Elevated tissue transglutaminase IgA (tTG-IgA) levels are highly specific for celiac disease, and they are a key biomarker used in its diagnosis. However, there are some rare instances where elevated tTG-IgA levels have been reported in conditions other than celiac disease. While these cases are not common, they have been documented in the literature. Below are some examples and references to studies or reviews that discuss these scenarios:  1. Non-Celiac Gluten Sensitivity (NCGS)    - NCGS typically does not cause elevated tTG-IgA levels, as it is not an autoimmune condition. However, some individuals with NCGS may have mild elevations in tTG-IgA due to intestinal inflammation or other factors, though this is not well-documented in large studies.    - Reference: Catassi, C., et al. (2013). *Non-Celiac Gluten Sensitivity: The New Frontier of Gluten-Related Disorders*. Nutrients, 5(10), 3839–3853. [DOI:10.3390/nu5103839](https://doi.org/10.3390/nu5103839)  2. Autoimmune Diseases    - Elevated tTG-IgA levels have been reported in other autoimmune conditions, such as type 1 diabetes, autoimmune hepatitis, and systemic lupus erythematosus (SLE). This is thought to be due to cross-reactivity or polyautoimmunity.    - Reference: Sblattero, D., et al. (2000). *The Role of Anti-Tissue Transglutaminase in the Diagnosis and Management of Celiac Disease*. Autoimmunity Reviews, 1(3), 129–135. [DOI:10.1016/S1568-9972(01)00022-3](https://doi.org/10.1016/S1568-9972(01)00022-3)  3. Chronic Liver Disease    - Conditions like chronic hepatitis or cirrhosis can sometimes lead to elevated tTG-IgA levels, possibly due to increased intestinal permeability or immune dysregulation.    - Reference: Vecchi, M., et al. (2003). *High Prevalence of Celiac Disease in Patients with Chronic Liver Disease: A Role for Gluten-Free Diet?* Gastroenterology, 125(5), 1522–1523. [DOI:10.1016/j.gastro.2003.08.031](https://doi.org/10.1016/j.gastro.2003.08.031)  4. Inflammatory Bowel Disease (IBD)    - Some patients with Crohn’s disease or ulcerative colitis may have elevated tTG-IgA levels due to intestinal inflammation and damage, though this is not common.    - Reference: Walker-Smith, J. A., et al. (1990). *Celiac Disease and Inflammatory Bowel Disease*. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 389–391. [DOI:10.1097/00005176-199004000-00020](https://doi.org/10.1097/00005176-199004000-00020)  5. Infections and Parasites    - While infections (e.g., giardiasis) are more commonly associated with false-positive tTG-IgA results, chronic infections or parasitic infestations can sometimes lead to elevated levels due to mucosal damage.    - Reference: Rostami, K., et al. (1999). *The Role of Infections in Celiac Disease*. European Journal of Gastroenterology & Hepatology, 11(11), 1255–1258. [DOI:10.1097/00042737-199911000-00010](https://doi.org/10.1097/00042737-199911000-00010)  6. Cardiac Conditions    - Rarely, heart failure or severe cardiovascular disease has been associated with elevated tTG-IgA levels, possibly due to gut ischemia and increased intestinal permeability.    - Reference: Ludvigsson, J. F., et al. (2007). *Celiac Disease and Risk of Cardiovascular Disease: A Population-Based Cohort Study*. American Heart Journal, 153(6), 972–976. [DOI:10.1016/j.ahj.2007.03.019](https://doi.org/10.1016/j.ahj.2007.03.019)  Key Points: - Elevated tTG-IgA levels are highly specific for celiac disease, and in most cases, a positive result strongly suggests celiac disease. - Other conditions causing elevated tTG-IgA are rare and often accompanied by additional clinical findings. - If celiac disease is suspected, further testing (e.g., endoscopy with biopsy) is typically required for confirmation. If you’re looking for more specific studies, I recommend searching PubMed or other medical databases using terms like "elevated tTG-IgA non-celiac" or "tTG-IgA in non-celiac conditions." Let me know if you’d like help with that!
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    • trents
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    • Jack Common
      Hello! I want to share my situation. I had symptoms like some food intolerance, diarrhea, bloating, belching one year ago. I thought I could have celiac disease so I did the blood tests. The results were ambiguous for me so I saw the doctor and he said I needed to do tests to check whether I had any parasites as well. It turned out I had giardiasis. After treating it my symptoms didn't disappear immediately. And I decided to start a gluten free diet despite my doctor said I didn't have it. After some time symptoms disappeared but that time it wasn't unclear whether I'd had them because of eliminating gluten or that parasite. The symptoms for both are very similar. Giardiasis also damages the small intestine. The only way to check this was to start eating bread again as I thought. Now about my results.   These are my first test results (almost a year ago) when I had symptoms: The Tissue Transglutaminase IgA antibody - 0.5 U/ml (for the lab I did the tests 0.0 - 3.0 is normal) The Tissue Transglutaminase IgG antibody - 6.6 U/ml (for the lab I did the tests 0.0 - 3.0 is normal) Immunoglobulin A - 1.91 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) IgA Endomysial antibody (EMA) - < 1:10 titer (for the lab I did the tests < 1:10 titer is normal) IgG Endomysial antibody (EMA) - < 1:10 titer (for the lab I did the tests < 1:10 titer is normal) Deamidated gliadin peptide IgA - 0.3 U/ml (for the lab I did the tests 0.0 - 6.0 is normal) Deamidated gliadin peptide IgG - 46.1 U/ml (for the lab I did the tests 0.0 - 6.0 is normal)   Then I didn't eat gluten for six months. Symptoms disappeared. And I started a gluten challenge. Before the challenge I did some tests. My results: The Tissue Transglutaminase IgG antibody - 0.5 U/ml (for the lab I did the tests < 20 U/ml is normal)) Deamidated gliadin peptide IgG - 28 U/ml (for the lab I did the tests < 20 U/ml is normal)   During the challenge I ate 6 slices of wheat bread. After the challenge my results are: The Tissue Transglutaminase IgA antibody - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) The Tissue Transglutaminase IgG antibody - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) Immunoglobulin A - 1.31 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) Deamidated gliadin peptide IgA - 2.0 U/ml (for the lab I did the tests < 20 U/ml is normal) Deamidated gliadin peptide IgG - 2.13 U/ml (for the lab I did the tests < 20 U/ml is normal)   To be sure I continued consuming gluten. I ate a lot each day. Two months after I did the tests again. My results I got today are: The Tissue Transglutaminase IgA antibody - 0.7 U/ml (for the lab I did the tests < 20 U/ml is normal) Immunoglobulin A - 1.62 g/l (for the lab I did the tests 0.7 to 4 g/l is normal) Deamidated gliadin peptide IgG - 25.6 U/ml (for the lab I did the tests < 20 U/ml is normal)   Nowadays I didn't have any symptoms except tiredness but I think it's just work. I think it was this parasite because two years ago, for example, and before I didn't have these symptoms and I always ate gluten food. But I'm still not sure especially because the Deamidated gliadin peptide IgG results are sometimes high. What do you think? @Scott Adams
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