Tolerateing Gluten-free Oats And Dq2.5

[OscarMathey]

HI - I recently read that about 25% celiacs carry the DQ2.5 gene and these people tend to NOT tolerate oats (pasted info below) even if they are gluten-free. I did have a DNA test but it only mentions DQ2 --- anyone know how to figure out if whether DQ2.5 is present? THANKS

My results were:

DQ2 homozygous 31x extremely high

DQ2/other high risk gene 16x very high

DQ2/DQ8 14x very high

DQ8 homozygous 10x high

DQ2 heterozygous 10x high

DQ8 heterozygous 2x modertae

DQ2/other low risk gene <1x low

DQ2 DQ8 <.1x extremly low

INfo on DQ2.5

Evidence that there are exceptional cases came in a 2004 study on oats.[10] The patients drafted for this study were those who had symptoms of celiac disease when on an 'pure-oat' challenge, therefore they do not represent the random population of celiacs. This study found that 4 patients had symptoms after oat ingestion, 3 had elevated Marsh scores for histology, and avenin responsive T-cells, indicating avenin-sensitive enteropathy(ASE). All three patients were DQ2.5/DQ2 (HLA DR3-DQ2/DR7-DQ2) phenotype. Patients with DQ2.5/DQ2.2 tend to be the most prone toward GSE, have the highest risk for GS-EATL, and shows signs of more severe disease at diagnosis. While DQ2.5/DQ2 phenotype represents only 25% of celiac patients, it accounts for all of the ASE celiacs, and 60-70% of patients with GS-EATL. Synthetic avenin peptides were synthesized either in native or deamidated form, the deamidated peptides showed higher response.

[kellynolan82]

  On 12/2/2008 at 7:33 PM, OscarMathey said:

HI - I recently read that about 25% celiacs carry the DQ2.5 gene and these people tend to NOT tolerate oats (pasted info below) even if they are gluten-free. I did have a DNA test but it only mentions DQ2 --- anyone know how to figure out if whether DQ2.5 is present? THANKS

My results were:

DQ2 homozygous 31x extremely high

DQ2/other high risk gene 16x very high

DQ2/DQ8 14x very high

DQ8 homozygous 10x high

DQ2 heterozygous 10x high

DQ8 heterozygous 2x modertae

DQ2/other low risk gene <1x low

DQ2 DQ8 <.1x extremly low

INfo on DQ2.5

Evidence that there are exceptional cases came in a 2004 study on oats.[10] The patients drafted for this study were those who had symptoms of celiac disease when on an 'pure-oat' challenge, therefore they do not represent the random population of celiacs. This study found that 4 patients had symptoms after oat ingestion, 3 had elevated Marsh scores for histology, and avenin responsive T-cells, indicating avenin-sensitive enteropathy(ASE). All three patients were DQ2.5/DQ2 (HLA DR3-DQ2/DR7-DQ2) phenotype. Patients with DQ2.5/DQ2.2 tend to be the most prone toward GSE, have the highest risk for GS-EATL, and shows signs of more severe disease at diagnosis. While DQ2.5/DQ2 phenotype represents only 25% of celiac patients, it accounts for all of the ASE celiacs, and 60-70% of patients with GS-EATL. Synthetic avenin peptides were synthesized either in native or deamidated form, the deamidated peptides showed higher response.

I thought oats were a problem for DQ8 celiacs more than DQ2 celiacs. With the DQ2 celiac vaccine in progress, it seems as though DQ2 involves 3 peptides (wheat, rye and barley).

[cyberprof]

  On 12/2/2008 at 7:33 PM, OscarMathey said:

HI - I recently read that about 25% celiacs carry the DQ2.5 gene and these people tend to NOT tolerate oats (pasted info below) even if they are gluten-free. I did have a DNA test but it only mentions DQ2 --- anyone know how to figure out if whether DQ2.5 is present? THANKS

My results were:

DQ2 homozygous 31x extremely high

DQ2/other high risk gene 16x very high

DQ2/DQ8 14x very high

DQ8 homozygous 10x high

DQ2 heterozygous 10x high

DQ8 heterozygous 2x modertae

DQ2/other low risk gene <1x low

DQ2 DQ8 <.1x extremly low

The notations above are not your results. That is the results "key" from the test. You should go back to your results or the lab and ask for your specific gene profile.

I'm dq2.5 and I cannot tolerate Bob's Red Mill but I can eat a little from a brand called "GlutenFree Oats" (which is a poor name for a brand). By little, I mean that I can make oatmeal cookies and eat 1 per day, or I can eat a serving of apple crisp and I don't react with oatmeal in meatloaf. I can't eat a whole bowl of oatmeal. If I eat too much I get symptoms.

[Skylark]

  On 8/11/2011 at 12:00 PM, kellynolan82 said:

I thought oats were a problem for DQ8 celiacs more than DQ2 celiacs. With the DQ2 celiac vaccine in progress, it seems as though DQ2 involves 3 peptides (wheat, rye and barley).

I've seen you post this supposition in a couple threads now. This is not correct and I am concerned that you are going to confuse people about oats. I assume it's the Science Translational Medicine article you're referring to?

Some HLA-DQ2 celiacs have been shown to have oat-reactive T cells.(1) The DQ2 paper where they mapped vaccine epitopes also had an oat aveenin fraction that stimulated T-cells in some of the subjects; the oat epitope just wasn't good enough or consistent enough to be of interest for a vaccine.(2)

(1) Arentz-Hansen H, Fleckenstein B, Molberg

[kellynolan82]

  On 8/11/2011 at 9:37 PM, Skylark said:

I've seen you post this supposition in a couple threads now. This is not correct and I am concerned that you are going to confuse people about oats. I assume it's the Science Translational Medicine article you're referring to?

Some HLA-DQ2 celiacs have been shown to have oat-reactive T cells.(1) The DQ2 paper where they mapped vaccine epitopes also had an oat aveenin fraction that stimulated T-cells in some of the subjects; the oat epitope just wasn't good enough or consistent enough to be of interest for a vaccine.(2)

(1) Arentz-Hansen H, Fleckenstein B, Molberg

[Skylark]

  On 8/12/2011 at 4:03 PM, kellynolan82 said:

How will the celiac vaccine work for those with the DQ2 gene who are also sensitive to oats then? Will they be able to eat wheat, rye and barley but have to avoid oats? Seems confusing to me. Please elaborate. I'd really appreciate it.

Your guess is as good as mine. Remember, there isn't even a vaccine yet.

[kellynolan82]

  On 8/12/2011 at 5:20 PM, Skylark said:

Your guess is as good as mine. Remember, there isn't even a vaccine yet.

And there may well never be one then. Seems as though celiac disease is more complex than we're prepared to admit.

It'll be interesting to see how this goes down though.