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Vitiligo Michael Jackson & I


EJR

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EJR Rookie

I have an auto-immune skin disease called Vitiligo. This is the same skin disease that Michael Jackson suffered from. You gradually lose the pigment in your skin and have to avoid very much sun exposure. I have read that Michael also had the auto-immune disease Lupus.

Just wondering if anyone knows if this skin disease is associated with or found in many people who also have Celiac disease / gluten sensitivity / intolerance? The pigment loss seems to have increased over the last year for me.

Joyce


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Type I, II, & III autoimmune polyglandular syndromes

PAS IIIC - Autoimmune thyroiditis with vitiligo and/or alopecia and/or other organ-specific autoimmune disease

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It looks like there are some links between celiac and vitilligo. Vitilligo is also associated with a lot of other autoimmune diseases.

eringopaint Newbie

My sister-in-law went gluten-free in support of my brother and my nephews, to simplify cooking and keep the kitchen as a safe zone. As a result her vitilago has stopped progressing, her life-long rhuemtoid arthritis no longer bothers her and her Doc just reduced her thyroid med dosage after being at the same level for years & years.

She has been gluten-free for about 3 yrs, maybe closer to 4.

Btw - she never had any stomach issues so never imagined anything would change when she stopped eating gluten.

I think celiac is related to all auto-immune diseases.

Are you following a gluten-free diet now?

~erin

ranger Enthusiast

Are there any genetic components to this skin thing? My mother had it and, although she was dxed with chrons, I strongly suspect she was celiac. Me and my sis are celiac.

EJR Rookie
My sister-in-law went gluten-free in support of my brother and my nephews, to simplify cooking and keep the kitchen as a safe zone. As a result her vitilago has stopped progressing, her life-long rhuemtoid arthritis no longer bothers her and her Doc just reduced her thyroid med dosage after being at the same level for years & years.

She has been gluten-free for about 3 yrs, maybe closer to 4.

Btw - she never had any stomach issues so never imagined anything would change when she stopped eating gluten.

I think celiac is related to all auto-immune diseases.

Are you following a gluten-free diet now?

~erin

Hi All,

Thank you for your replies. Ranger you asked if I am following a gluten-free diet. Yes, I have been on the diet for about a year now but have eaten about 6 slices of toast during that time period because I wasn't sure of what was going on. I had a small bowel biopsy that was negative for celiac (but I had already been gluten free for a few months). I just received gene test results from Prometheus Labs. I have one of the genes associated with Celiac disease (the DQ8 Heterozygous). Apparently about 8% of Celiacs have this gene. I have just ordered tests from Enterolab so will be interesting to see what they have to say.

So far I would say that my vitiligo has still been progressing. It develops so slowly and of course is much more noticeable in the summer when the skin gets a bit tanned. Otherwise my skin is so fair it isn't that noticeable.

It appears that there is an association with Celiac disease and vitiligo although it isn't as strong as some of the other auto-immune disorders. Thank you all again for taking the time to answer my post.

Joyce

  • 1 year later...
Golden Girl Rookie

Hi All,

When I went for my biopsy the Dr looked at me and said I more than likely have Celiac disease because I have vitiligo. She had said there are studies that have linked them together. As it turned out I do have Celiac disease. I am also hypothyroid. I only wish it could have been diagnosed 30 years ago actually 40 years ago when I was diagnosed with vitiligo. 2 years ago I had 3 mini strokes, veritgo and I was so mal-nutritioned. I feel a lot better gluten free. But I still have some symptoms foot pain and tingling in my finger tips.

Karla

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    • Nicbent35
      Well I had a moment yesterday morning where I accidentally gave her gluten. She wanted what I was eating and I forgot and let her have a few bites of toast. It was a really bad night last night with her behavior. Will a few bites of bread influence their behavior that much or could it just be a coincidence?
    • Scott Adams
      The first set of results show two positive results for celiac disease, so at the very least it looks like you could have it, or at the least NCGS.   Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.      
    • Scott Adams
      Elevated tissue transglutaminase IgA (tTG-IgA) levels are highly specific for celiac disease, and they are a key biomarker used in its diagnosis. However, there are some rare instances where elevated tTG-IgA levels have been reported in conditions other than celiac disease. While these cases are not common, they have been documented in the literature. Below are some examples and references to studies or reviews that discuss these scenarios:  1. Non-Celiac Gluten Sensitivity (NCGS)    - NCGS typically does not cause elevated tTG-IgA levels, as it is not an autoimmune condition. However, some individuals with NCGS may have mild elevations in tTG-IgA due to intestinal inflammation or other factors, though this is not well-documented in large studies.    - Reference: Catassi, C., et al. (2013). *Non-Celiac Gluten Sensitivity: The New Frontier of Gluten-Related Disorders*. Nutrients, 5(10), 3839–3853. [DOI:10.3390/nu5103839](https://doi.org/10.3390/nu5103839)  2. Autoimmune Diseases    - Elevated tTG-IgA levels have been reported in other autoimmune conditions, such as type 1 diabetes, autoimmune hepatitis, and systemic lupus erythematosus (SLE). This is thought to be due to cross-reactivity or polyautoimmunity.    - Reference: Sblattero, D., et al. (2000). *The Role of Anti-Tissue Transglutaminase in the Diagnosis and Management of Celiac Disease*. Autoimmunity Reviews, 1(3), 129–135. [DOI:10.1016/S1568-9972(01)00022-3](https://doi.org/10.1016/S1568-9972(01)00022-3)  3. Chronic Liver Disease    - Conditions like chronic hepatitis or cirrhosis can sometimes lead to elevated tTG-IgA levels, possibly due to increased intestinal permeability or immune dysregulation.    - Reference: Vecchi, M., et al. (2003). *High Prevalence of Celiac Disease in Patients with Chronic Liver Disease: A Role for Gluten-Free Diet?* Gastroenterology, 125(5), 1522–1523. [DOI:10.1016/j.gastro.2003.08.031](https://doi.org/10.1016/j.gastro.2003.08.031)  4. Inflammatory Bowel Disease (IBD)    - Some patients with Crohn’s disease or ulcerative colitis may have elevated tTG-IgA levels due to intestinal inflammation and damage, though this is not common.    - Reference: Walker-Smith, J. A., et al. (1990). *Celiac Disease and Inflammatory Bowel Disease*. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 389–391. [DOI:10.1097/00005176-199004000-00020](https://doi.org/10.1097/00005176-199004000-00020)  5. Infections and Parasites    - While infections (e.g., giardiasis) are more commonly associated with false-positive tTG-IgA results, chronic infections or parasitic infestations can sometimes lead to elevated levels due to mucosal damage.    - Reference: Rostami, K., et al. (1999). *The Role of Infections in Celiac Disease*. European Journal of Gastroenterology & Hepatology, 11(11), 1255–1258. [DOI:10.1097/00042737-199911000-00010](https://doi.org/10.1097/00042737-199911000-00010)  6. Cardiac Conditions    - Rarely, heart failure or severe cardiovascular disease has been associated with elevated tTG-IgA levels, possibly due to gut ischemia and increased intestinal permeability.    - Reference: Ludvigsson, J. F., et al. (2007). *Celiac Disease and Risk of Cardiovascular Disease: A Population-Based Cohort Study*. American Heart Journal, 153(6), 972–976. [DOI:10.1016/j.ahj.2007.03.019](https://doi.org/10.1016/j.ahj.2007.03.019)  Key Points: - Elevated tTG-IgA levels are highly specific for celiac disease, and in most cases, a positive result strongly suggests celiac disease. - Other conditions causing elevated tTG-IgA are rare and often accompanied by additional clinical findings. - If celiac disease is suspected, further testing (e.g., endoscopy with biopsy) is typically required for confirmation. If you’re looking for more specific studies, I recommend searching PubMed or other medical databases using terms like "elevated tTG-IgA non-celiac" or "tTG-IgA in non-celiac conditions." Let me know if you’d like help with that!
    • MaryMJ
      I called zero water and they state their filters do not contain gluten or gluten containing ingredients. 
    • trents
      I agree. Doesn't look like you have celiac disease. Your elevated DGP-IGG must be due to something else. And it was within normal at that after your gluten challenge so it is erratic and doesn't seem to be tied to gluten consumption.
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