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Can't Make Sense Of My Bloodwork


Laurelf

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Laurelf Explorer

I am so sad. It looks like my bloodwork is negative. I was so hopeful that I found a solution since going g.f has made me feel so much better. Here are the results of my bloodtests. It looks like the ranges are next to the results, but I can't tell if they are the total ranges of the test or the limits of normal.

Endomysial AB negative

Gliadin IgA 1.3 (0.0 - 10.0)

Gliadin IgG .8 (0.0 - 10.0)

Transglut AB 1 (0-3)

So for IgA, does that mean the highest they test for is 10?

Thanks


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ravenwoodglass Mentor

First off your body can tell you more than the blood tests can. There are false negatives in both blood and biopsy so go by how you feel off of gluten and how you react when you add it back in. Also if you were gluten free or gluten light when the tests were done that will insure a false negative. It also does not appear they did a total IGA on you. If you are IGA deficient the tests are worthless. If you feel better gluten free then stay gluten free, you don't need a doctors permission. There are also times when after being gluten free and having all your medical issues resolve doctors will give a diagnosis based on your response to the diet.

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    • knitty kitty
      Welcome to the forum, @Kiwifruit, I agree further testing is needed.  Disaccharidase deficiency is a symptom of Celiac disease.   On your test results, this line  "IgA: 0.9 g/l (norm 0.8 - 4.0)" is referring to Total IgA and it's very low.  People with low or deficient Total IgA should also have DGP IgG test done.  Low Total IgA means you are making low levels of tTg  IgA as well, leading to false negatives or "weak positives".  Maybe a DNA test for known Celiac genes.   Anemia, diabetes, and thiamine deficiency can cause test results like these.  Get checked for B12 deficiency anemia and have your iron (ferritin) checked.  Vitamin D deficiency is common, too.   Might be time to find a gastrointestinal doctor who is more familiar with diagnosing Celiac Disease.   Best wishes on your journey!  Please keep us posted on your progress.  
    • trents
      Yes, there is a trend in the medical community to forego the endoscopy/biopsy and grant an official celiac diagnosis based on high tTG-IGA antibody scores alone. This trend started in the UK and is spreading to the USA medical community. And yes, 5-10x the normal level is what I have been seeing as the threshold as well. Here is the relevant section dealing from the article above dealing with the importance of the total IGA test being ordered. See the embedded attachment.
    • hmkr
      Ok, interesting. Not what I was thinking that meant. I'm reading the article and trying to understand. I see this “According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy” My IgG is 90, which is 6 times. So to me that means it's highly likely I do have it. 
    • trents
      It just means you aren't IGA deficient, i.e., that IGA deficiency cannot have given you artificially low scores in the individual IGA celiac antibody tests. This is explained in the article Scott linked above.
    • hmkr
      Normal range: 70 - 400 mg/dL, a little above middle of the range. So what does that mean? Thank you! I will check out that page you linked. Appreciate it! 
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