Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Is Iga Deficiency Reversible With A Gluten Free Diet?


Annelet

Recommended Posts

Annelet Newbie

I have secretory IgA deficiency which showed up on a saliva sample.

Positive fecal anti-gliadin antibodies from Enterolab. DQ8+DQ1 genes. Gluten free for 3 months.

Years ago I was tested several times for immunoglobulins and they were always 'normal'....no IgA deficiency.

So.....does gluten cause an aquired IgA deficiency?

..... Is this reversible on a gluten free diet?

.......can you have a normal serum IgA, but a very low secretory IgA ?

Anne


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



gfp Enthusiast
I have secretory IgA deficiency which showed up on a saliva sample.

Positive fecal anti-gliadin antibodies from Enterolab. DQ8+DQ1 genes. Gluten free for 3 months.

Years ago I was tested several times for immunoglobulins and they were always 'normal'....no IgA deficiency.

So.....does gluten cause an aquired IgA deficiency?

..... Is this reversible on a gluten free diet?

.......can you have a normal serum IgA, but a very low secretory IgA ?

Anne

I'm not an expert but I don't think so.

Low IgA is just something comes along for the ride with the 'weird' DQ human antigen profiles for celiacs.

Is it possible you were tested for IgA serum but not the deficiency? (You say years ago and testing has moved on and IgA deficiency now 'included' in screening). This is partly just progress, the increased IgA deficiency awareness is partly (IMHO) just due to more people having different IgA tests and the frequency and numbers of people being tested as well as different test methods.

However: Also to my knowledge IgA deficiency in itself is not harmful.

Of interest there are 6 immunoglobulin (antibody) types: (well classes) (in placental mammals - this is sorta important of interest as expanded below)

Open Original Shared Link

IgA is the only anti body transmitted through milk (human and otherwise) (hence the placental mammals)

IgG is the only one which crosses the placenta and gives immunity to new borns.

IgA is 'mainly' secreted in mucosal areas gut, respiratory tract and urogenital tract ... and can prevent parasitic colonization but IgG is the major 'bacteria and virus' killer.

Hope this helps ...

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      128,167
    • Most Online (within 30 mins)
      7,748

    Renira Boodhraj
    Newest Member
    Renira Boodhraj
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.1k
    • Total Posts
      70.7k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • trents
      Have you considered the possibility that you might have NCGS (Non Celiac Gluten Sensitivity) rather than celiac disease? They share many of the same symptoms, the difference being that NCGS does not damage the lining of the small bowel. It is 10x more common than celiac disease. There is no test yet available for NCGS. Celiac disease must first be ruled out. In view of your genetic profile, I would give it consideration.
    • Kj44
    • mariamccl
      Hi, 25f who recently had a endoscopy procedure to diagnose celiac disease. Mum and uncle are both diagnosed celiacs. I've had symptoms over the past year - headaches that have become debilitating and frequent, feeling faint and nauseous with high heart rate, diarrhea and constipation, anemia, and recently my periods have become almost non existent. My doctor sent me a letter yesterday saying this " biopsies from the duodenum show some very mild features that could be in keeping with celiac disease but also could be due to other causes". I am waiting on an appointment to see him in the clinic to discuss this but in the meantime I wanted to check if anyone else has experienced this? I was eating plenty of gluten before my camera test and for the past 2 weeks have completely cut it out of my diet and I'm seeing changes in my bowel movements for the first time in my life! Headaches, dizziness etc are still there but maybe it takes longer for them to go away? Any help would be so appreciated -  I feel so lost in this whole process!! 
    • trents
      Did your symptoms improve after going on a gluten-free diet?
    • Scott Adams
      Thank you for sharing your genetic test results and background. Your results indicate you carry one half of the DQ2 heterodimer (DQA1*05), which is associated with a very low celiac disease risk (0.05%). While most celiac patients have either DQ2 or DQ8, these genes are also present in people without celiac disease, so the test alone doesn’t confirm a diagnosis. Since you’ve been gluten-free for 10 years, traditional diagnostic methods (like endoscopy or blood tests) would not be reliable now. If an official diagnosis is important to you, consider discussing a gluten challenge with your doctor, where you reintroduce gluten for a period before testing. Alternatively, you could focus on symptom management and dietary adherence, as your gluten-free diet seems to be helping. Consulting a gastroenterologist or celiac specialist could provide further clarity.  Here is more info about how to do a gluten challenge for a celiac disease blood panel, or for an endoscopy: and this recent study recommends 4-6 slices of wheat bread per day:    
×
×
  • Create New...