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Hives


EJR

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Two days ago I developed a number of red, itchy, hives? on the back of one leg (from the knee down).

The old welts look slightly dried up and new ones keep appearing higher up on the leg.

There is one on my other leg. At least 10 or so on the affected leg. They are fairly large and

really itchy. The skin on my back feels itchy but no sign of hives.

Anyone have experience with hives? I also have extreme lower abdominal bloating and abdominal pain but

this is almost a daily occurrence no matter what I eat so I'm not sure if the two are related at all. My liver enzymes

were elevated the last time I saw the doctor. Was retested so will see on Monday if they are still high. I had done

a gluten challenge the day before the first blood test was taken.

I have been mainly gluten free for 1 1/2 years. Enterolab testing showed elevated anti-gliadian antibodies and

a main celiac gene (DQ8) and a gluten sensitivity gene.

The last time I had hives was many years ago and believe it or not they were from chewing gum (any

kind would do the trick). Still don't really understand this allergy.

About 18 years ago all of my body broke out in something that the dermatologist called eczema. It was dreadfully

itchy....I could only wear a sheet for almost a week. Treated with steroid creams. Left my skin very sensitive to polyester

and many other materials and products.

I get terrible red, itchy welts from swimming in many lakes and used to get hives a lot as a child from pork and strawberries.

Am I going back to my childhood (I'm 63 years old now). I seem to be developing allergies and food intolerances

to everything. I was President of the SPCA here for many years and 5 years ago I developed a serious allergy to

cats, dust, weeds and mold. Then eggs and also became lactose intolerant. Since gall bladder removal have been

unable to eat gluten or nuts, corn, rice. Yikes! Have lost 50 lbs since Dec. 2007.

And now I'm getting hives from something. Laundry detergent is the same. I cannot figure out why these red, itchy

hives are almost exclusively appearing on one leg. Everyday there seems to be a few knew ones. The only new foods

I had introduced were fresh dates (I checked re gluten free) and baked apples. Have removed these today to see if it makes any difference.

Thanks for any opinions or feedback.

Itchy Joyce


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I have been mainly gluten free for 1 1/2 years. Enterolab testing showed elevated anti-gliadian antibodies and

a main celiac gene (DQ8) and a gluten sensitivity gene. Itchy Joyce

Mainly gluten free wont' do it. Try going gluten free to see if the rash goes away.

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    • Nicbent35
      Well I had a moment yesterday morning where I accidentally gave her gluten. She wanted what I was eating and I forgot and let her have a few bites of toast. It was a really bad night last night with her behavior. Will a few bites of bread influence their behavior that much or could it just be a coincidence?
    • Scott Adams
      The first set of results show two positive results for celiac disease, so at the very least it looks like you could have it, or at the least NCGS.   Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.      
    • Scott Adams
      Elevated tissue transglutaminase IgA (tTG-IgA) levels are highly specific for celiac disease, and they are a key biomarker used in its diagnosis. However, there are some rare instances where elevated tTG-IgA levels have been reported in conditions other than celiac disease. While these cases are not common, they have been documented in the literature. Below are some examples and references to studies or reviews that discuss these scenarios:  1. Non-Celiac Gluten Sensitivity (NCGS)    - NCGS typically does not cause elevated tTG-IgA levels, as it is not an autoimmune condition. However, some individuals with NCGS may have mild elevations in tTG-IgA due to intestinal inflammation or other factors, though this is not well-documented in large studies.    - Reference: Catassi, C., et al. (2013). *Non-Celiac Gluten Sensitivity: The New Frontier of Gluten-Related Disorders*. Nutrients, 5(10), 3839–3853. [DOI:10.3390/nu5103839](https://doi.org/10.3390/nu5103839)  2. Autoimmune Diseases    - Elevated tTG-IgA levels have been reported in other autoimmune conditions, such as type 1 diabetes, autoimmune hepatitis, and systemic lupus erythematosus (SLE). This is thought to be due to cross-reactivity or polyautoimmunity.    - Reference: Sblattero, D., et al. (2000). *The Role of Anti-Tissue Transglutaminase in the Diagnosis and Management of Celiac Disease*. Autoimmunity Reviews, 1(3), 129–135. [DOI:10.1016/S1568-9972(01)00022-3](https://doi.org/10.1016/S1568-9972(01)00022-3)  3. Chronic Liver Disease    - Conditions like chronic hepatitis or cirrhosis can sometimes lead to elevated tTG-IgA levels, possibly due to increased intestinal permeability or immune dysregulation.    - Reference: Vecchi, M., et al. (2003). *High Prevalence of Celiac Disease in Patients with Chronic Liver Disease: A Role for Gluten-Free Diet?* Gastroenterology, 125(5), 1522–1523. [DOI:10.1016/j.gastro.2003.08.031](https://doi.org/10.1016/j.gastro.2003.08.031)  4. Inflammatory Bowel Disease (IBD)    - Some patients with Crohn’s disease or ulcerative colitis may have elevated tTG-IgA levels due to intestinal inflammation and damage, though this is not common.    - Reference: Walker-Smith, J. A., et al. (1990). *Celiac Disease and Inflammatory Bowel Disease*. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 389–391. [DOI:10.1097/00005176-199004000-00020](https://doi.org/10.1097/00005176-199004000-00020)  5. Infections and Parasites    - While infections (e.g., giardiasis) are more commonly associated with false-positive tTG-IgA results, chronic infections or parasitic infestations can sometimes lead to elevated levels due to mucosal damage.    - Reference: Rostami, K., et al. (1999). *The Role of Infections in Celiac Disease*. European Journal of Gastroenterology & Hepatology, 11(11), 1255–1258. [DOI:10.1097/00042737-199911000-00010](https://doi.org/10.1097/00042737-199911000-00010)  6. Cardiac Conditions    - Rarely, heart failure or severe cardiovascular disease has been associated with elevated tTG-IgA levels, possibly due to gut ischemia and increased intestinal permeability.    - Reference: Ludvigsson, J. F., et al. (2007). *Celiac Disease and Risk of Cardiovascular Disease: A Population-Based Cohort Study*. American Heart Journal, 153(6), 972–976. [DOI:10.1016/j.ahj.2007.03.019](https://doi.org/10.1016/j.ahj.2007.03.019)  Key Points: - Elevated tTG-IgA levels are highly specific for celiac disease, and in most cases, a positive result strongly suggests celiac disease. - Other conditions causing elevated tTG-IgA are rare and often accompanied by additional clinical findings. - If celiac disease is suspected, further testing (e.g., endoscopy with biopsy) is typically required for confirmation. If you’re looking for more specific studies, I recommend searching PubMed or other medical databases using terms like "elevated tTG-IgA non-celiac" or "tTG-IgA in non-celiac conditions." Let me know if you’d like help with that!
    • MaryMJ
      I called zero water and they state their filters do not contain gluten or gluten containing ingredients. 
    • trents
      I agree. Doesn't look like you have celiac disease. Your elevated DGP-IGG must be due to something else. And it was within normal at that after your gluten challenge so it is erratic and doesn't seem to be tied to gluten consumption.
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