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Test Results

1boy1girl

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1boy1girl Newbie
1boy1girl
Posted

I got the call yesterday that my son has Celiac Disease. I asked if I could have his test results this morning (so I could post them here and get them explained to me). I picked them up but they didn't give me much. They had said there is damage to the intestine but nothing like that is here and really there is very little on this piece of paper she gave me. Here is what she wrote....

GLIADIN/GLUTEN IGG AB 30

GLIADIN/GLUTEN IGA AB 3

tTG IGA AB 3

IMMUNOGLOBULIN A (IGA) SERUM 142

Can anyone explain this to me? Is this all I need to know? Is this enough? They first said he had IBS. We ended up with a new doctor who ran a ton of tests and x-rays and said Celiac. Should I ask for more results or just accept the diagnosis? We have gone gluten free but since we just got the call yesterday he has only had 3 meals so far. I've been reading/studying everything I can get my hands on and checked out some cookbooks from the library today. I also have an appointment with a dietician. Thanks for the help in advance.

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tarnalberry Community Regular
tarnalberry
Posted

I got the call yesterday that my son has Celiac Disease. I asked if I could have his test results this morning (so I could post them here and get them explained to me). I picked them up but they didn't give me much. They had said there is damage to the intestine but nothing like that is here and really there is very little on this piece of paper she gave me. Here is what she wrote....

GLIADIN/GLUTEN IGG AB 30

GLIADIN/GLUTEN IGA AB 3

tTG IGA AB 3

IMMUNOGLOBULIN A (IGA) SERUM 142

Can anyone explain this to me? Is this all I need to know? Is this enough? They first said he had IBS. We ended up with a new doctor who ran a ton of tests and x-rays and said Celiac. Should I ask for more results or just accept the diagnosis? We have gone gluten free but since we just got the call yesterday he has only had 3 meals so far. I've been reading/studying everything I can get my hands on and checked out some cookbooks from the library today. I also have an appointment with a dietician. Thanks for the help in advance.

What they gave you isn't enough. If you didn't get a copy of the lab report itself, but rather a hand written note, demand a copy of the lab report. You need reference ranges to compare the values to. (On a guess, I'm guessing that just the IgG test went positive, but the biopsy results - which are not listed in what you typed at all - were positive.)

1boy1girl Newbie
1boy1girl
Posted
  • Author

What they gave you isn't enough. If you didn't get a copy of the lab report itself, but rather a hand written note, demand a copy of the lab report. You need reference ranges to compare the values to. (On a guess, I'm guessing that just the IgG test went positive, but the biopsy results - which are not listed in what you typed at all - were positive.)

I called and asked for the ranges. She said the first one is >17 positive. The second one is <11 negative. The third one is <5 negative. He has not had a biopsy yet. He had ultrasound and x-rays that show problems. And lots of blood work. The biopsy has to wait a couple weeks because we have to go out of town to see my sister (last stages of cancer). My son is 14. He was told it was IBS 2 years ago. The doctor who told us that did not do blood work so I am not sure what made him decide that. Since IBS runs in the family I accepted it. He just kept getting worse. That caused us to try to find answers. This doctor says Celiac. Should I accept it or wait until the biopsy? Could it be something else causing a false positive?

nora-n Rookie
nora-n
Posted

This is a high antigliadin IgG result.

Just shows the importance of testing for that test too, not just the tissue trasnglutaminase IgA.

The total IgA was okay, and they do that test just to check if the IgA type tests are valid.

Now the endomysium and the antigliadin test are the old tesst, and afterwards they got the tissue transglutaminase test.

Now whenever they invent a new test they write lots of articles bragging how bad the old tests were and how good the new fancy expensive test is.

Now when you ahvwe read several of these things, it really looks like just marketing, they want to sell more tests.

If you google ford gluten you can find some explanation about the antigliadin IgG test, and why it is so important, and not to dismiss it.

(at the same time you can see how they tout the new deamidated gliadin test which is supposed to be so much better than the trasglutaminase test, which used to be so much better than the antigliadin test, which was so much better than whatever...)

I really think the test does mean something.

The child should NOT go completely gluten free right now, must wait until after the biopsy.

In children the villi heal so fast the biopsies could go indeterminate in a couple of weeks off gluten.

You really want a diagnosis right now.

tarnalberry Community Regular
tarnalberry
Posted

False positives are extraordinarily rare. (Virtually never. But hey, labs can make mistakes. :/)

Whether to take him gluten free now or not entirely depends on your (and his) need for an official diagnosis. If you want an official diagnosis, he needs to stay on gluten (and plenty of it) before the biopsy. If you don't care if he ever has a doctors dx, then you can take him off (he'd need to be *STRICTLY* gluten free) for a few weeks (6-8, at least) and see if there are any changes. Not an easy decision. Given his age, I'm not sure what I would do in that situation.

Jestgar Rising Star
Jestgar
Posted

Since IBS runs in the family I accepted it.

Maybe it's Celiac that runs in the family.....

ravenwoodglass Mentor
ravenwoodglass
Posted

Maybe it's Celiac that runs in the family.....

I was thinking the same thing. It is very important that you not take him gluten free yet. Wait until the day he has the biopsy then go right from the procedure to a gluten free diet. I would also let other family members know that with his positive blood work it is really pretty certain that he is celiac so they should be tested also.

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    • trents
      Does High DGP IGA Typically Mean Celiac?

      By trents · Posted

      Keep us posted and let us know the results of the biopsy. Your case is atypical in a way in that you have this high DGP-IGA but normal TTG-IGA so knowing how it turns out will give us more data for similar situations that may be posted in the future. 
    • Skg414228
      Does High DGP IGA Typically Mean Celiac?

      By Skg414228 · Posted

      Fair enough! I very easily could have misread somewhere. Celiac is very confusing lol but I should know in a little over a month what the final verdict is. Just thought chatting with people smarter than myself would get me in the right mindset. I just thought that DGP IGA was pretty high compared to some stuff I had seen and figured someone on here would be more willing to say it is more than likely celiac instead of my doctor who is trying to be less direct. She did finally say she believes it is celiac but wanted to confirm with the biopsy. I did figure it wouldn't hurt seeing what other people said too just because not all doctors are the best. I think mine is actually pretty good from what I have seen but I don't know what I don't know lol. Sorry lot of rambling here just trying to get every thought out. Thanks again!
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      Does High DGP IGA Typically Mean Celiac?

      By trents · Posted

      No, you don't necessarily need multiple testing methods to confirm celiac disease. There is an increasing trend for celiac diagnoses to be made on a single very high tTG-IGA test score. This started in the UK during the COVID pandemic when there was extreme stress on the healthcare system there and it is spreading to the US. A tTG-IGA score of somewhere between 5x and 10x normal is good enough by itself for some physicians to declare celiac disease. And mind you, that is the tTG-IGA, not the DGP-IGA. The tTG-IGA is the centerpiece of celiac antibody testing, the one test most commonly ordered and the one that physicians have the most confidence in. But in the US, many physicians still insist on a biopsy, even in the event of high tTG-IGA scores. Correct, the biopsy is considered "confirmation" of the blood antibody testing. But what is the need for confirmation of a testing methodology if the testing methodology is fool proof? As for the contribution of genetic testing for celiac disease, it cannot be used to diagnose celiac disease since 40% of the general population has the genetic potential to develop celiac disease while only 1% of the general population actually develops celiac disease. But it can be used to rule out celiac disease. That is, if you don't have the genes, you don't have celiac disease but you might have NCGS (Non Celiac Gluten Sensitivity).
    • Skg414228
      Does High DGP IGA Typically Mean Celiac?

      By Skg414228 · Posted

      Okay yeah that helps! To answer your last bit my understanding was that you need to have multiple tests to confirm celiac. Blood, biopsy, dna, and then I think symptoms is another one. Either way I think everything has to be confirmed with the biopsy because that is the gold standard for testing (Doctors words). You also answered another question I forgot to ask about which is does a high value push to a higher % on those scales. I truly appreciate your answers though and just like hearing what other people think. Digging into forums and google for similar stuff has been tough. So thank you again!
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