Gene Question......

[Luvbeingamommy]

My son and I both had our genes tested through enterolab, my doctor ended up checking mine too. If I have 2,6 and my son has 2,7, where did he get the "7" ? Does this mean my husband carries it??

would it be a good idea to get my other two children checked, one is almost 5 and one is 10 months. My 2 year old is the one who was having major GI issues. I just kind of want to know if one of my kids has the 6 like I do, because neuro issues can be pretty serious and I just got so blessed that my stroke hit the part of the brain it did.

If I asked our family doctor to check their genes, they wouldn't check the sensitivity part. Maybe I'd be best to go through Enterolab??

[Korwyn]

Hi Luvbeingamommy!

Yes, the "DQ7" gene would have come from your husband. Enterolab seems to test the widest set of genes that I have been able to find, though someone else on here might have more info. I know Prometheous didn't test for anything more than the two main genes as of the last time I checked.

[Luvbeingamommy]

Really, interesting. So if my kiddos will have a gluten sensitive gene it will be either 6 or 7??

You think it's a good idea to test or only if issues come up??

[frieze]

Really, interesting. So if my kiddos will have a gluten sensitive gene it will be either 6 or 7??

You think it's a good idea to test or only if issues come up??

your husband has another gene for that loci (or whatever the proper term is,lol) it is likely that it would show up in your other children....

[Luvbeingamommy]

your husband has another gene for that loci (or whatever the proper term is,lol) it is likely that it would show up in your other children....

Hmm, all this gene stuff is confusing! Maybe someday I will understand....

[Korwyn]

Ok I'll try and give you a quick synopsis.

There are 8 (possibly 9) genes identified as being related to celiac disease and/or gluten intolerance. A person could potentially have up to two genes - one from each of parent. This is very very over simplified, but basic. The percentages have much to do with dominant and recessive genes and things, but basically that it what it boils down to.

There are others on this board that can give you a much more accurate and detailed explanation about them and what the different genes seem to trigger (so far as research has uncovered to date). DQ7 is one of the more complex of the genes in terms of how it is (or isn't) linked to various other auto-immune diseases as it appears to act differently depending on your genetic ethnic genotype and what other genes are nearby.

[Luvbeingamommy]

Interesting, I had not read much about the 7, a little on the 6 though.

Okay it makes sense to me now, at least much more . I am not sure whether or not to get my other two kiddos tested, or even my husband??

Fussy baby, but thanks for your response!!

[ravenwoodglass]

Interesting, I had not read much about the 7, a little on the 6 though.

Okay it makes sense to me now, at least much more . I am not sure whether or not to get my other two kiddos tested, or even my husband??

Fussy baby, but thanks for your response!!

I would encourage your husband to be tested. Your children definately should be tested now and test them again at puberty, that is what they do in countries that screen everyone. Then retest them if they start to show symptoms. Do keep in mind that the testing on children has an even higher rate of false negatives than with adults so if they seem symptomatic a trial of the diet is in order.

I would not do this with gene testing as not everyone who carries the genes develops celiac. The gene testing can be interesting but is not diagnostic.

[Luvbeingamommy]

I would encourage your husband to be tested. Your children definately should be tested now and test them again at puberty, that is what they do in countries that screen everyone. Then retest them if they start to show symptoms. Do keep in mind that the testing on children has an even higher rate of false negatives than with adults so if they seem symptomatic a trial of the diet is in order.

I would not do this with gene testing as not everyone who carries the genes develops celiac. The gene testing can be interesting but is not diagnostic.

So would you say test my children that aren't showing many symptoms?? My almost 5 year old has always had, "poop issues". He use to struggle with constipation, but now it's weird I have to force him to poop or he won't. He fights it, but then usually does go.

My daughter is only 11 months old, I am just going pretty light on the gluten with her, mainly because with my son and myself being gluten free she is mainly too.