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Consensus On Which Blood Test Best Indicates Celiac?

MIB

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MIB Newbie
MIB
Posted

Hello folks. Like many might during the discovery phase, I have been doing a lot of research while waiting for more results to come in. Doc and I have just decided to extend the 3-week gluten binge to six weeks, assuming I am still managing to pack it away that long. Today was day four. I had been off gluten only 35 days.

Anyway, here's my question. My bloodtests were taken before I went off gluten. TTG was clearly negative (<3 with a reference value of <5), Gliadin IgG was 40 (normal is <11), and Gliadin IgA was 14 (normal <11). Reticulin Antibody IgA simply said "negative." First doctor thought this was equivocal and therefore did not merit further testing. Current doc has me challenging so we can do an endoscopy.

Any sense of which numbers are more indicative of celiac? Two of those tests are clearly positive, the IgG significantly so.

THANKS.

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Skylark Collaborator
Skylark
Posted

TTG and reticulin are autoimmune antibodies and clearly indicate celiac. Reticulin is particularly specific, while TTG can sometimes appear in other autoimmune diseases. Anti-gliadin is only a reaction to gliadin, not an autoimmune antibody, and it is notoriously inaccurate as far as celiac disease. You may be gluten intolerant, or you may be one of the celiacs who doesn't make a lot of antibodies.

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