Jump to content

  • You are not alone. Join Celiac.com for trusted gluten-free answers and forum support.



  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

Super Over-Reactions To Novacaine, Etc.

IrishHeart

By IrishHeart
in Super Sensitive People

Recommended Posts

IrishHeart Veteran
IrishHeart
Posted

Maybe you other super sensitives know why I react so strongly to even the smallest doses of medications, and to novacaine at the dentist, even the eye drops at the eye doctor yesterday. (They just confirmed to me that it is rare for someone's pupils to remain dilated and light- sensitive longer than 24 hours and for my face to be flushed red hot, plus I feel agitated and nauseous.They said some people lack a certain protein which affects how one responds to these drugs? I don't know--all I Know is my vision is still blurry. :blink: ) These kinds of things affect me for days--I feel sick and out of it. Geesh!

I know it's not gluten doing it, but I am just wondering if anyone else has these "heightened" responses--almost like an allergy-- to meds that usually wear off shortly in other people?

Thanks, guys ;) .

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


GlutenFreeManna Rising Star
GlutenFreeManna
Posted

Oh my YES! I take one Benedryl and I am knocked out. I can't keep my eyes open. If I take two Bendryl I will sleep for at least 12 hours and be really groggy/strugglign to wake up for the next 48 hours. I can't take strong pain killers (Opiate-based) without really severe reactions. The only things I don't really have trouble with is Ibuprofen and Pepto Bismol. I would love to know why and if this is at all related to gluten.

IrishHeart Veteran
IrishHeart
Posted
  • Author

Oh my YES! I take one Benedryl and I am knocked out. I can't keep my eyes open. If I take two Bendryl I will sleep for at least 12 hours and be really groggy/strugglign to wake up for the next 48 hours. I can't take strong pain killers (Opiate-based) without really severe reactions. The only things I don't really have trouble with is Ibuprofen and Pepto Bismol. I would love to know why and if this is at all related to gluten.

That is weird, because when I take opiods--I get AGITATED instead of knocked out :blink: Sleep meds, pain meds??---might as well give me shots of adrenaline.

If I take a xanax--offered to me for sleep?--or flexeril for muscle pain---I am doped up for a few days...even a little tiny bit does me in. So, I don't take anything!

Benadryl--I lie awake with heart palps and raciness....almost like I do with gluten---which BTW...I call the "gluten willies" :lol:

One doctor suggested it is because we are not absorbing medications properly because of our guts...makes sense? I know that in years past, I had no trouble with meds, etc..,.,just since I got sick.

GlutenFreeManna Rising Star
GlutenFreeManna
Posted

That is weird, because when I take opiods--I get AGITATED instead of knocked out :blink: Sleep meds, pain meds??---might as well give me shots of adrenaline.

If I take a xanax--offered to me for sleep?--or flexeril for muscle pain---I am doped up for a few days...even a little tiny bit does me in. So, I don't take anything!

Benadryl--I lie awake with heart palps and raciness....almost like I do with gluten---which BTW...I call the "gluten willies" :lol:

One doctor suggested it is because we are not absorbing medications properly because of our guts...makes sense? I know that in years past, I had no trouble with meds, etc..,.,just since I got sick.

I have that reaction to Sudafed--the heart racing and wide-awake, feelign like I could run a marathon or liek I just ingested a large amount of caffiene. My chest hurts for days afterward. I wonder if we could be reacting to the dyes in some meds?

I also get really, really emotional from pain meds that don't knock me out. Like, my husband could tell me that we are out of toilet paper and I would break down crying as if my best friend just died. And I don't know why I am crying over it, just that I can't stop. I had a concussion a few years ago and this was my reaction to taking one vicodin. Crying jags for days over little things that didn't matter to me. I thought I was losing my mind.

lovegrov Collaborator
lovegrov
Posted

There are folks who do not have celiac who have similar problems. Doubt celiac has anything to do with it.

richard

Poppi Enthusiast
Poppi
Posted

I'm like that too. My heart races like crazy when I get a novocaine shot at the dentist. He told me there is adrenaline mixed into the medication but that most people don't feel it like I do. Last time he was numbing me up for a root canal I thought my heart was going to stop, even the dentist got worried for a minute of two.

cahill Collaborator
cahill
Posted

My GI doc recently diagnosed me with Gilbert-Meulengracht syndrome,

one of the complications of Gilbert's is that the liver is unable to detoxify the body of certain drugs leading to ,,among other things,,a hypersensitivity to those drugs .

My daughter is totally convinced that my celiac's is connected to my Gilbert's . The origin of Gilberts is a flaw(?) in ones DNA,, makes me wonder :huh:

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


IrishHeart Veteran
IrishHeart
Posted
  • Author

My GI doc recently diagnosed me with Gilbert-Meulengracht syndrome,

one of the complications of Gilbert's is that the liver is unable to detoxify the body of certain drugs leading to ,,among other things,,a hypersensitivity to those drugs .

My daughter is totally convinced that my celiac's is connected to my Gilbert's . The origin of Gilberts is a flaw(?) in ones DNA,, makes me wonder :huh:

That's what my doctor suggested --that the liver might be having trouble filtering drugs. I was pretty jaundiced for a while there. Not anymore. Thanks for your thoughts! Whatever the case, it sure makes me "racy" :rolleyes: My dentist feels bad whenever he has to work on me :lol:

IrishHeart Veteran
IrishHeart
Posted
  • Author

I'm like that too. My heart races like crazy when I get a novocaine shot at the dentist. He told me there is adrenaline mixed into the medication but that most people don't feel it like I do. Last time he was numbing me up for a root canal I thought my heart was going to stop, even the dentist got worried for a minute of two.

me, too--and I got cold and started to tremble..they put a blanket on me--I felt like such a silly .... :rolleyes:

cahill Collaborator
cahill
Posted

That's what my doctor suggested --that the liver might be having trouble filtering drugs. I was pretty jaundiced for a while there. Not anymore. Thanks for your thoughts! Whatever the case, it sure makes me "racy" :rolleyes: My dentist feels bad whenever he has to work on me :lol:

I knew I was pretty jaundiced when my 6 year old granddaughter said to me " gram you look like a banana :lol:

I try to avoid any drugs ,even OTC drugs, if at all possible

IrishHeart Veteran
IrishHeart
Posted
  • Author

I knew I was pretty jaundiced when my 6 year old granddaughter said to me " gram you look like a banana :lol:

I try to avoid any drugs ,even OTC drugs, if at all possible

banana huh? :) -- I was more "golden beige"... :blink:

me too...I suffer with chronic pain rather than take anything...geesh!

domesticactivist Collaborator
domesticactivist
Posted

I don't have celiac but I'm also very sensitive to medications and over the years have really minimized their use. It seems like if there's a rare side effect, I'll get it, and half the time medications don't have the intended effect on me. My dad is the same way.

I have a friend with grave's disease who also reacts very strongly to novacaine, btw.

IrishHeart Veteran
IrishHeart
Posted
  • Author

I don't have celiac but I'm also very sensitive to medications and over the years have really minimized their use. It seems like if there's a rare side effect, I'll get it, and half the time medications don't have the intended effect on me. My dad is the same way.

I have a friend with grave's disease who also reacts very strongly to novacaine, btw.

Thanks for your thoughts. Yes, my Mom shares my "sensitivity" as well. You should have seen me on morphine post- hysterectomy--yikes!! Not good. :blink:

I am like you--if it has a "rare" side effect--I'm sure to have it occur!

I am sitting here with sunglasses on having had my pupils dilated YESTERDAY for an exam...my vision is still blurry and my irises are practically non-existent. Doctor says it is very rare, well, maybe...but it happened, nonetheless. B) Lucky me :P

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. cristiana
      - cristiana replied to CC90's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      7

      Coeliac or not coeliac

      Hello @CC90 Can I just ask a question: have you actually been told that your biopsy were normal, or just that your stomach, duodenum and small intestine looked normal? The reason I ask is that when I had my endoscopy, I was told everything looked normal. My TTG score was completely through the roof at the time, greater than 100 which was then the cut...
    2. trents
      - trents replied to CC90's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      7

      Coeliac or not coeliac

      My bad. I should have reread your first post as for some reason I was thinking your TTG was within normal range. While we are talking about celiac antibody blood work, you might not realize that there is not yet an industry standard rating scale in use for those blood tests so just having a raw number with out the reference scale can be less than helpful...
    3. knitty kitty
      - knitty kitty replied to CC90's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      7

      Coeliac or not coeliac

      @CC90, Your Lansoprazole is a proton pump inhibitor and has immunosuppressive effects!!!! This is why your endoscopy didn't show much damage to the intestinal lining!! The Lansolprazole is suppressing tTg IgA antibodies in the intestines, but those antibodies are getting into the blood stream and causing inflammation and damage in other organs...
    4. knitty kitty
      - knitty kitty replied to kevert93's topic in Gluten-Free Foods, Products, Shopping & Medications
      4

      Having issues with chips

      Hi, @kevert93, Those Gluten Assist enzymes digest carbohydrates, not just gluten specifically. Eating a high carbohydrate meal can deplete Thiamine Vitamin B 1 causing digestive symptoms like you describe. You could also be having difficulty digesting the oils used in those chips. Thiamine in the form Benfotiamine can help. We need the eight...
    5. CC90
      - CC90 replied to CC90's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      7

      Coeliac or not coeliac

      Thank you for responding. I didn't intentionally reduce gluten prior to the endoscopy though I dont generally eat a lot of it due to the unpleasant symptoms. I was under the impression my TTG of 87.4 was very high, at least that's what my doctor said.
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      134,184
    • Most Online (within 30 mins)
      10,442
    Dennis E. Schertz
    Newest Member
    Dennis E. Schertz
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.7k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • cristiana
      Coeliac or not coeliac

      By cristiana · Posted

      Hello @CC90 Can I just ask a question: have you actually been told that your biopsy were normal, or just that your stomach, duodenum and small intestine looked normal? The reason I ask is that when I had my endoscopy, I was told everything looked normal.  My TTG score was completely through the roof at the time, greater than 100 which was then the cut off max. for my local lab.  Yet when my biopsy results came back, I was told I was stage 3 on the Marsh scale.  I've come across the same thing with at least one other person on this forum who was told everything looked normal, but the report was not talking about the actual biopsy samples, which had to be looked at through a microscope and came back abnormal.
    • trents
      Coeliac or not coeliac

      By trents · Posted

      My bad. I should have reread your first post as for some reason I was thinking your TTG was within normal range. While we are talking about celiac antibody blood work, you might not realize that there is not yet an industry standard rating scale in use for those blood tests so just having a raw number with out the reference scale can be less than helpful, especially when the test results are marginal. But a result of 87.4 is probably out of the normal range and into the positive range for any lab's scale. But back to the question of why your endoscopy/biopsy didn't show damage despite significantly positive TTG. Because they took the trouble to take seven samples, it is not likely they missed damage because of it being patchy. The other possibility is that there hasn't been time for the damage to show up. How long have you been experiencing the symptoms you describe in your first post? Having said all that, there are other medical conditions that can cause elevated TTG-IGA values and sometimes they are transient issues. I think it would be wise to ask for another TTG-IGA before the repeat endoscopy to see if it is still high.  Knitty kitty's suggestion of getting genetic testing done is also something to think about. About 35% of the general population will have one or both genes that are markers for the potential to develop active celiac disease but only about 1% of the population actually develop celiac disease. So, having a celiac potential gene cannot be used to definitively diagnose celiac disease but it can be realistically used to rule it out if you don't have either of the genes. If your symptoms persist, and all testing is complete and the follow-up endoscopy/biopsy still shows no damage, you should consider trialing a gluten free diet for a few months to see if symptoms improve. If not celiac disease, you could have NCGS (Non Celiac Gluten Sensitivity). 
    • knitty kitty
      Coeliac or not coeliac

      By knitty kitty · Posted

      @CC90, Your Lansoprazole is a proton pump inhibitor and has immunosuppressive effects!!!!  This is why your endoscopy didn't show much damage to the intestinal lining!!  The Lansolprazole is suppressing tTg IgA antibodies in the intestines, but those antibodies are getting into the blood stream and causing inflammation and damage in other organs.   Proton pump inhibitors cause intestinal damage in the long run.  If you get off the Lansoprazole for a few months so your immune system is not blocked, then do a gluten challenge, and an endoscopy, THEN they would see intestinal damage. Sheesh!  Doctors can be so ignorant.  I've seen this so many times it's frustrating! Take the B Complex and Benfotiamine.  Get off the Lansoprazole.  Go with the DNA test results.   Welcome to the tribe! P.S. B vitamins are needed to correct anemia!  Not just iron.  
    • knitty kitty
      Having issues with chips

      By knitty kitty · Posted

      Hi, @kevert93, Those Gluten Assist enzymes digest carbohydrates, not just gluten specifically.  Eating a high carbohydrate meal can deplete Thiamine Vitamin B 1 causing digestive symptoms like you describe.  You could also be having difficulty digesting the oils used in those chips.  Thiamine in the form Benfotiamine can help. We need the eight B vitamins to digest our food, carbs, fats and proteins.  Poor digestion can cause symptoms like vomiting and stomach pain, brain fog, headaches, exhaustion.  Try taking a B Complex with the activated forms of the B vitamins (Life Extension's Bioactive B Complex is great!) and additional Benfotiamine.  The B vitamins are used to make digestive enzymes and will allow your digestive system to function properly.  The B vitamins also will improve headaches, exhaustion, and brain function.  Taking Thiamine in the form Benfotiamine will improve digestive symptoms and lower inflammation, too.  Benfotiamine and the B vitamins are safe.  The B vitamins are chemical compounds found in whole foods, not in highly processed foods like chips.   The body cannot make the B vitamins, so supplementing is beneficial.  Benfotiamine is safe and nontoxic even in high doses.
    • CC90
      Coeliac or not coeliac

      By CC90 · Posted

      Thank you for responding.  I didn't intentionally reduce gluten prior to the endoscopy though I dont generally eat a lot of it due to the unpleasant symptoms. I was under the impression my TTG of 87.4 was very high, at least that's what my doctor said.  
×
×
  • Create New...