Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Super Over-Reactions To Novacaine, Etc.

IrishHeart

By IrishHeart
in Super Sensitive People

Recommended Posts

IrishHeart Veteran
IrishHeart
Posted

Maybe you other super sensitives know why I react so strongly to even the smallest doses of medications, and to novacaine at the dentist, even the eye drops at the eye doctor yesterday. (They just confirmed to me that it is rare for someone's pupils to remain dilated and light- sensitive longer than 24 hours and for my face to be flushed red hot, plus I feel agitated and nauseous.They said some people lack a certain protein which affects how one responds to these drugs? I don't know--all I Know is my vision is still blurry. :blink: ) These kinds of things affect me for days--I feel sick and out of it. Geesh!

I know it's not gluten doing it, but I am just wondering if anyone else has these "heightened" responses--almost like an allergy-- to meds that usually wear off shortly in other people?

Thanks, guys ;) .

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


GlutenFreeManna Rising Star
GlutenFreeManna
Posted

Oh my YES! I take one Benedryl and I am knocked out. I can't keep my eyes open. If I take two Bendryl I will sleep for at least 12 hours and be really groggy/strugglign to wake up for the next 48 hours. I can't take strong pain killers (Opiate-based) without really severe reactions. The only things I don't really have trouble with is Ibuprofen and Pepto Bismol. I would love to know why and if this is at all related to gluten.

IrishHeart Veteran
IrishHeart
Posted
  • Author

Oh my YES! I take one Benedryl and I am knocked out. I can't keep my eyes open. If I take two Bendryl I will sleep for at least 12 hours and be really groggy/strugglign to wake up for the next 48 hours. I can't take strong pain killers (Opiate-based) without really severe reactions. The only things I don't really have trouble with is Ibuprofen and Pepto Bismol. I would love to know why and if this is at all related to gluten.

That is weird, because when I take opiods--I get AGITATED instead of knocked out :blink: Sleep meds, pain meds??---might as well give me shots of adrenaline.

If I take a xanax--offered to me for sleep?--or flexeril for muscle pain---I am doped up for a few days...even a little tiny bit does me in. So, I don't take anything!

Benadryl--I lie awake with heart palps and raciness....almost like I do with gluten---which BTW...I call the "gluten willies" :lol:

One doctor suggested it is because we are not absorbing medications properly because of our guts...makes sense? I know that in years past, I had no trouble with meds, etc..,.,just since I got sick.

GlutenFreeManna Rising Star
GlutenFreeManna
Posted

That is weird, because when I take opiods--I get AGITATED instead of knocked out :blink: Sleep meds, pain meds??---might as well give me shots of adrenaline.

If I take a xanax--offered to me for sleep?--or flexeril for muscle pain---I am doped up for a few days...even a little tiny bit does me in. So, I don't take anything!

Benadryl--I lie awake with heart palps and raciness....almost like I do with gluten---which BTW...I call the "gluten willies" :lol:

One doctor suggested it is because we are not absorbing medications properly because of our guts...makes sense? I know that in years past, I had no trouble with meds, etc..,.,just since I got sick.

I have that reaction to Sudafed--the heart racing and wide-awake, feelign like I could run a marathon or liek I just ingested a large amount of caffiene. My chest hurts for days afterward. I wonder if we could be reacting to the dyes in some meds?

I also get really, really emotional from pain meds that don't knock me out. Like, my husband could tell me that we are out of toilet paper and I would break down crying as if my best friend just died. And I don't know why I am crying over it, just that I can't stop. I had a concussion a few years ago and this was my reaction to taking one vicodin. Crying jags for days over little things that didn't matter to me. I thought I was losing my mind.

lovegrov Collaborator
lovegrov
Posted

There are folks who do not have celiac who have similar problems. Doubt celiac has anything to do with it.

richard

Poppi Enthusiast
Poppi
Posted

I'm like that too. My heart races like crazy when I get a novocaine shot at the dentist. He told me there is adrenaline mixed into the medication but that most people don't feel it like I do. Last time he was numbing me up for a root canal I thought my heart was going to stop, even the dentist got worried for a minute of two.

cahill Collaborator
cahill
Posted

My GI doc recently diagnosed me with Gilbert-Meulengracht syndrome,

one of the complications of Gilbert's is that the liver is unable to detoxify the body of certain drugs leading to ,,among other things,,a hypersensitivity to those drugs .

My daughter is totally convinced that my celiac's is connected to my Gilbert's . The origin of Gilberts is a flaw(?) in ones DNA,, makes me wonder :huh:

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


IrishHeart Veteran
IrishHeart
Posted
  • Author

My GI doc recently diagnosed me with Gilbert-Meulengracht syndrome,

one of the complications of Gilbert's is that the liver is unable to detoxify the body of certain drugs leading to ,,among other things,,a hypersensitivity to those drugs .

My daughter is totally convinced that my celiac's is connected to my Gilbert's . The origin of Gilberts is a flaw(?) in ones DNA,, makes me wonder :huh:

That's what my doctor suggested --that the liver might be having trouble filtering drugs. I was pretty jaundiced for a while there. Not anymore. Thanks for your thoughts! Whatever the case, it sure makes me "racy" :rolleyes: My dentist feels bad whenever he has to work on me :lol:

IrishHeart Veteran
IrishHeart
Posted
  • Author

I'm like that too. My heart races like crazy when I get a novocaine shot at the dentist. He told me there is adrenaline mixed into the medication but that most people don't feel it like I do. Last time he was numbing me up for a root canal I thought my heart was going to stop, even the dentist got worried for a minute of two.

me, too--and I got cold and started to tremble..they put a blanket on me--I felt like such a silly .... :rolleyes:

cahill Collaborator
cahill
Posted

That's what my doctor suggested --that the liver might be having trouble filtering drugs. I was pretty jaundiced for a while there. Not anymore. Thanks for your thoughts! Whatever the case, it sure makes me "racy" :rolleyes: My dentist feels bad whenever he has to work on me :lol:

I knew I was pretty jaundiced when my 6 year old granddaughter said to me " gram you look like a banana :lol:

I try to avoid any drugs ,even OTC drugs, if at all possible

IrishHeart Veteran
IrishHeart
Posted
  • Author

I knew I was pretty jaundiced when my 6 year old granddaughter said to me " gram you look like a banana :lol:

I try to avoid any drugs ,even OTC drugs, if at all possible

banana huh? :) -- I was more "golden beige"... :blink:

me too...I suffer with chronic pain rather than take anything...geesh!

domesticactivist Collaborator
domesticactivist
Posted

I don't have celiac but I'm also very sensitive to medications and over the years have really minimized their use. It seems like if there's a rare side effect, I'll get it, and half the time medications don't have the intended effect on me. My dad is the same way.

I have a friend with grave's disease who also reacts very strongly to novacaine, btw.

IrishHeart Veteran
IrishHeart
Posted
  • Author

I don't have celiac but I'm also very sensitive to medications and over the years have really minimized their use. It seems like if there's a rare side effect, I'll get it, and half the time medications don't have the intended effect on me. My dad is the same way.

I have a friend with grave's disease who also reacts very strongly to novacaine, btw.

Thanks for your thoughts. Yes, my Mom shares my "sensitivity" as well. You should have seen me on morphine post- hysterectomy--yikes!! Not good. :blink:

I am like you--if it has a "rare" side effect--I'm sure to have it occur!

I am sitting here with sunglasses on having had my pupils dilated YESTERDAY for an exam...my vision is still blurry and my irises are practically non-existent. Doctor says it is very rare, well, maybe...but it happened, nonetheless. B) Lucky me :P

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. MogwaiStripe
      - MogwaiStripe posted a topic in Dermatitis Herpetiformis
      0

      Dermatitis Herpetiformis Cleared up With EpiPen, etc.

      I had to rush to the hospital last week due to anaphylactic shock from taking a dose of an antibiotic. Received EpiPen, steroids, antihistamines, zofran (all injected/IV). When I woke up the next day, ALL of the rashes I've had that started since going gluten free were cleared up. EVEN THE dermatitis herpetiformis was gone. Has anyone else experienced this...
    2. Dr. Gunn
      - Dr. Gunn replied to MicG's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      7

      Test interpretations

      Exactly! Negative genetics can rule out celiac disease with close to 100% certainty. It takes tTg antibody testing and biopsy confirm the diagnosis in a genetically susceptible individual.
    3. trents
      - trents replied to MicG's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      7

      Test interpretations

      What Dr. Gunn states is essentially true. It is a rule out measure. But be aware that to possess either of the two primary genes that have been identified with celiac disease (or both) doesn't necessarily mean that you have or will develop celiac disease. Almost 40% of the general population carries one or both but only about 1% of the general population...
    4. Dr. Gunn
      - Dr. Gunn replied to MicG's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      7

      Test interpretations

      Have you had celiac genetic risk testing? A celiac genetic test is accurate with or without gluten in your diet. If you don't carry the celiac risk genes you can effectively rule out celiac disease for life.
    5. Aretaeus Cappadocia
      - Aretaeus Cappadocia commented on Scott Adams's article in Spring 2026 Issue
      1

      How Social Media Algorithms Are Fueling Gluten Anxiety: TikTok, Reddit, and Instagram Trends

      Good, balanced analysis. I liked the comparison of the different platforms in this context. Fwiw, the same essay largely would work if you substitute any of many contemporary topics. As a moderator of this site, have you stepped back and considered how this site fits into this essay? Personally, I don't think I have enough visibility into the comments...
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      133,660
    • Most Online (within 30 mins)
      7,748
    FionaHunt
    Newest Member
    FionaHunt
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.6k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • MogwaiStripe
      Dermatitis Herpetiformis Cleared up With EpiPen, etc.

      By MogwaiStripe · Posted

      I had to rush to the hospital last week due to anaphylactic shock from taking a dose of an antibiotic. Received EpiPen, steroids, antihistamines, zofran (all injected/IV). When I woke up the next day, ALL of the rashes I've had that started since going gluten free were cleared up. EVEN THE dermatitis herpetiformis was gone. Has anyone else experienced this or happen to know why that would happen? The meds they gave me were all meds that I've taken to try to resolve the rashes, but they never worked in pill form. I'm wondering if it the addition of the epi that helped, it if injected steroids and antihistamines were what did the job.
    • Dr. Gunn
      Test interpretations

      By Dr. Gunn · Posted

      Exactly! Negative genetics can rule out celiac disease with close to 100% certainty. It takes tTg antibody testing and biopsy confirm the diagnosis in a genetically susceptible individual. 
    • trents
      Test interpretations

      By trents · Posted

      What Dr. Gunn states is essentially true. It is a rule out measure. But be aware that to possess either of the two primary genes that have been identified with celiac disease (or both) doesn't necessarily mean that you have or will develop celiac disease. Almost 40% of the general population carries one or both but only about 1% of the general population will develop active celiac disease. It remains latent until triggered by some stress event which may or may not occur. So, there is a genetic component to celiac disease but there is also an epigenetic component. 
    • Dr. Gunn
      Test interpretations

      By Dr. Gunn · Posted

      Have you had celiac genetic risk testing? A celiac genetic test is accurate with or without gluten in your diet. If you don't carry the celiac risk genes you can effectively rule out celiac disease for life. 
    • Scott Adams
      Test interpretations

      By Scott Adams · Posted

      Based on those results alone, it’s not possible to say you have celiac disease. The test that is usually most specific for celiac, tTG-IgA, is negative in your results, and the endomysial antibody (EMA) is also negative, which generally argues against active celiac disease. However, your deamidated gliadin IgA is elevated, and your total IgA level is also high, which can sometimes affect how the other antibody tests behave. Another important factor is that you were reducing gluten before the test, which can lower antibody levels and make the results less reliable. Because of that, many doctors recommend a gluten challenge (eating gluten regularly for several weeks) before repeating blood tests or considering an endoscopy if symptoms and labs raise concern. It would be best to review these results with a gastroenterologist, who can interpret them in context and decide whether further testing is needed.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.