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Anti-Glidan Positive And This Article On Celiac.com?

TJSpin

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TJSpin Rookie
TJSpin
Posted

According to this article on celiac.com, it states that if one has a positive anti-glidan IgA test, there is a 97% probability that they have celiac disease. Is this really the correct figure? Am I reading this correctly? Is there much of a reason to do any more testing for a 6 year old?

Anti-glidan IgA 73 units.

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kareng Grand Master
kareng
Posted

You need to look at dates on this forum. That article is 15 years old. You might find more up to date info? Test may have changed? Maybe someone who knows about the current testing could comment but the usual wisdom is that if a test for Celiac is positive, you have Celiac.

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TJSpin Rookie
TJSpin
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Posted

You need to look at dates on this forum. That article is 15 years old. You might find more up to date info? Test may have changed? Maybe someone who knows about the current testing could comment but the usual wisdom is that if a test for Celiac is positive, you have Celiac.

Yes, I noticed the dates. It is very old, for sure. This is just all so confusing. I guess I'll wait for the transglutaminaswe test to come back and go from there. Just reading that made my heart sink for my little gal....although nothing different will occur.

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ravenwoodglass Mentor
ravenwoodglass
Posted

It is my understanding that yes if that test it positive it is pretty certain the person has celiac even if the TtG is negative. There are newer tests, DGP, that have been developed because of a high rate of false negatives on the Anti-gliadin but when it is positive it is positive. If your doctor will diagnose so your child will be kept safe in school without the biopsy then it is your choice whether to biopsy. A person needs to stay on gluten until all testing is done and do keep in mind that false negatives on biopsy are possible so the child needs to do the diet no matter what the biopsy results when blood tests are positive.

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Skylark Collaborator
Skylark
Posted

You need to look at dates on this forum. That article is 15 years old. You might find more up to date info? Test may have changed? Maybe someone who knows about the current testing could comment but the usual wisdom is that if a test for Celiac is positive, you have Celiac.

I agree with looking at dates. In this case ELISA methodology has become somewhat more sensitive in the last 15 years but we're still looking at essentially the same test. They would have been reading biopsies more conservatively in 1996 but if anything that would lower the specificity. It's hard to find newer studies on AGA because that's about the time they were developing TTG, which is a lot more sensitive. AGA IgG has poor sensitivity (I've seen studies where the sensitivity was below 50%) but if it's present the specificity in kids usually comes out over 90%.

Don't let your heart sink. Your little girl is blessed that she has been diagnosed early and can grow up healthy!

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