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celiac disease Associated Autoantibodies In Dh Published 4/12

squirmingitch

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squirmingitch Veteran
squirmingitch
Posted

I know this is some really important info. for us & may give those of us with dh a better chance for testing & dx. I'm not that great at understanding EXACTLY how much hope this gives us though. Some of you have a better grasp of medical techno lingo &/or may be able to access the entire article. Would like comments on this.

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Novel assay for detecting celiac disease-associated autoantibodies in dermatitis herpetiformis using deamidated gliadin-analogous fusion peptides.

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pricklypear1971 Community Regular
pricklypear1971
Posted

I can't being anything intelligent to the discussion but what is the GAF3x?

squirmingitch Veteran
squirmingitch
Posted
  • Author

I think it's this:

deamidated gliadin-analogous fusion

peptides

(GAF3X)

see:

https://www.celiac.com/articles/21901/1/Antibodies-to-Deamidated-Gliadin-as-a-Tool-in-Diagnosing-Childhood-Celiac-Disease/Page1.html

pricklypear1971 Community Regular
pricklypear1971
Posted

Hmm. I looked on the LabCorp site and don't see it - or don't think I see it. I wonder which labs offer it.

squirmingitch Veteran
squirmingitch
Posted
  • Author

This is also what they say is better for detecting celiac in children.

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pricklypear1971 Community Regular
pricklypear1971
Posted

Yes, but how do you GET it?

squirmingitch Veteran
squirmingitch
Posted
  • Author

I haven't the foggiest notion. I did a search too for Labs who do it & couldn't get anywhere --- just kept coming up with the article abstract.

Ask doctors?

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ciamarie Rookie
ciamarie
Posted

Dunno. But it does look promising, as far as a tool for detecting DH / celiac without biopsy!

itchy Rookie
itchy
Posted

I took it to mean that in tests (done correctly) the false negative level will be 30%. Or possibly the false positive rate. In any case it appears that the tests will be slightly better and there are at least eight researchers working on improving them. THat's good news to me.

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