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Iga Antibodies And Negative Test Results


cindylou7

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cindylou7 Apprentice

Can low (still within normal) IgA antibodies affect blood test and skin biopsies?

On another note, I've been faithful to gluten-free diet and haven't had any noticeable GI symptoms that would indicate accidental glutening, but I had a breakout of DH on my skin on my arm and a return of what I always thought of as acne on my neck. It's sort of like a cyst and similar to the ones on my bottom. The only thing different in my diet is an increase in pickles/pickle juice, and I recently gave blood. Iodine? I've never noticed a connection for me.

I still have tons of questions about gluten intolerance.


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squirmingitch Veteran

Yes, low IgA antibodies can affect blood tests & skin biopsies. But the question is moot b/c you have been gluten free for quite some time now. Cindylou, nothing you do short of eating gluten for some time will give you any positive test results now ---- NOTHING.

DH can break out at any time EVEN though you have been eating gluten free for up to 2 years & EVEN longer --- some texts say up to 10 years.

cindylou7 Apprentice

Yes, low IgA antibodies can affect blood tests & skin biopsies. But the question is moot b/c you have been gluten free for quite some time now. Cindylou, nothing you do short of eating gluten for some time will give you any positive test results now ---- NOTHING.

DH can break out at any time EVEN though you have been eating gluten free for up to 2 years & EVEN longer --- some texts say up to 10 years.

Thanks...

I wasn't wondering so I could test again, I had an "ah ha" moment and was looking for clarification. My IgA test results were in the low normal range and my tests have all been negative but I know I react to gluten and have improved bloodwork as a result of gluten-free diet.

I'm not certain that the cyst type acne is DH but I suspect it is. I have scarring from previous bumps and they don't have any pigmentation. The other blister type (herpes looking) bumps are easy to identify as different from other skin problems, but these are similar to acne. I thought it was unusual and suspect that they all popped out at once. Of course I looked for a cause...

squirmingitch Veteran

We can have other skin problems in conjunction with the dh which can make figuring things out tricky. And from my own personal experience as well as what has been related on here by others as well as medical texts--- the darn dh can take so many forms. I had blisters, blisters, blisters & the bite kind of dh ---- now I'm in a spell where I'm not getting any blisters but the bite kind are prevalent as well as some that seem deep under the skin & they appear as red, inflamed bumps & they still itch like crazy but also sting & burn & they get really deep down sore --- hurts to touch them the least bit. I almost get bruising from them very faintly.

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    • ChrisSeth
      Okay thanks Scott. So based on my results will they order more tests to be done? Kind of confused.
    • Scott Adams
      Yes, this sounds right. Let us know when you find out your results.
    • ChrisSeth
      Hi thanks for your response! This is the only other info that’s on my test results for the IgA. The initial testing performed in the Celiac Disease Reflex Panel is the total IgA. If the total IgA is <10 mg/dL, the reflex tests that will be ordered are the Tissue Transglutaminase IgG Antibody and the Deamidated Gliadin Peptide IgG Antibody. If the total IgA is >=10 mg/dL, the reflex test that will be ordered is the Tissue Transglutaminase IgA Antibody. Does that give some insight?  following up with my Dr early next week… thanks again.  And I didn’t eat more gluten than usual during the last 6-8 weeks on purpose. Just a normal diet prior to testing. I had gluten everyday for 6-8 weeks though I’m sure.
    • Scott Adams
      Have you tried sheep's milk and goat's milk cheeses? After my diagnosis I could not tolerate cow's milk for ~2 years until my villi healed, but for some reason I did not have issues with sheep milk or goat milk cheeses.  I also had temporary issues with chicken eggs, but could eat duck eggs.
    • Scott Adams
      This is not a test for celiac disease, but your total IgA levels. This test is usually done with other celiac disease blood tests to make sure the results are accurate. Did they do a tTg-IgA test as well? Were you eating lots of gluten in the 6-8 weeks leading up to your blood tests? This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate.    
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