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Russ H

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Celiac.com - Celiac Disease & Gluten-Free Diet Support Since 1995

Everything posted by Russ H

  1. Russ H
    You have isolated positive anti-DGP: in the absence of a person having IgA deficiency, this has poor positive predictive value for coeliac disease - 15.5% (95% CI 8.5–25.0%). This is because it is not unusual for people without coeliac disease to have DGP antibodies. https://celiacdiseasecenter.columbia.edu/wp-content/uploads/2018/12/Diagnostic-Yield-o...
  2. Russ H
    I agree with Scott and Trents. It is concerning that your GI specialist is totally wrong regarding the necessity to keep eating gluten prior to the blood test - this is basic stuff.
  3. Russ H
    Yes, that sounds wrong. According to the UK's NICE it is estimated that 3% of men and 8% of women have iron deficiency anaemia. Also, there are many other conditions caused by coeliac disease that they don't include: central and peripheral neuropathies, cardiac arrhythmia, chilblains, androgen resistance.
  4. Russ H
    It can take several years to fully recover. It is also a very trying condition due to the dietary restrictions. I was diagnosed 2.5 years ago and am still recovering. I didn't realise how ill I had been and for how long. As I started to recover, it hit me and I felt really sorry for myself and grieved over the lost decades of quality life. For people who...
  5. Russ H
    I have drunk this beer without issue although people vary in their sensitivity to gluten. This beer is a barley lager that is treated with an enzyme such as Clarex to degrade any gluten remaining after the brewing process and then batch tested to verify that it is less than 20 parts per million gluten. The enzyme attacks the proline groups in gluten molecules...
  6. Russ H
    I was plagued with body odour since childhood and it disappeared when I began following a strict gluten free diet. It returned when I went back on gluten for testing. I had to change my clothes several times a day and used to scrub myself so much in the shower that I developed dry skin and eczema. I have read several people reporting strong body odour with...
  7. Russ H
    Yes. You can make much better bread than you can buy. Some of the recipes are quite time consuming and convoluted but make excellent bread. I have a Panasonic - they are great bread machines. You can often get one on offer on Amazon or other outlets. Then you can try this and other recipes: https://www.glutenfreealchemist.com/gluten-free-bread-machine...
  8. Russ H
    The proteins in wheat are problematic because mammals cannot completely digest them and large fragments remain as they pass through the gut. A fragment of one of the proteins called gliadin binds to an enzyme found in the gut called tissue transglutaminase (tTG2) and forms a highly immunogenic complex - in this process it loses an amide group and become positively...
  9. Russ H
    Yes, Angostura bitters contain gentian root, which is alleged to help digestive problems in herbal medicine. There is no evidence that they help and could well antagonise a sensitive stomach.
  10. Russ H
    You certainly can have coeliac disease while not having the common HLA types although it is not common - about 1% of people with coeliac don't have the common HLA types. https://www.coeliac.org.uk/information-and-support/coeliac-disease/about-coeliac-disease/causes/genetics/
  11. Russ H
    At least some people with coeliac disease can occasionally eat gluten without reacting to it. Coeliac disease has been known since the Ancient Greeks but despite being a specific food intolerance, its cause only began to be hypothesised in the 1940s and the exact cause established in 1952. With food allergies it is easy to establish the cause because the...
  12. Russ H
    These references do not refute the paper I posted. The second reference, "Diagnostic accuracy of anti-DGP (IgG) for celiac disease", does not compare isolated anti-DGP with anti-tTG2. This is a common mistake - when both anti-DGP and anti-tTG2 are raised it indicates coeliac disease. However, isolated anti-DGP is not predictive of coeliac disease in...
  13. Russ H
    That study showed 7 of 62 children had coeliac disease, which is 11%. However, that is a small sample so there is considerable uncertainty in the figure. If I remember my stats, the standard deviation will be the square root of 7, so the actual value is likely between 7% and 15%.
  14. Russ H
    The EMA test just detects IgA anti-tTG2 but is relatively crude and insensitive compared with modern IgA tTG2 testing. This is why it is more specific but less sensitive. EMA testing came about as a chance finding from some research where people with coeliac disease were used as a control group, and it was discovered that they had antibodies that bind...
  15. Russ H
    Wheat allergy may involve an allergic reaction to gluten - the proteins present in wheat. It is absolutely possible to be allergic to gluten. Coeliac disease is not an allergic response to gluten, it involves a different immune response. https://www.anaphylaxis.org.uk/fact-sheet/wheat-allergy/
  16. Russ H
    You have isolated DGP-IgG. This is common in people who do not have coeliac disease and so by itself is not usefully predictive. https://onlinelibrary.wiley.com/doi/full/10.1111/jpc.16071
  17. Russ H
    Generating a coeliac-type immune response to oats (as in T-cells recognising avenin) is uncommon. People with untreated coeliac disease often have antibodies to oats but they also have antibodies to several other foods such as milk, and these disappear on a strict gluten-free diet. I suspect that a lot of people react to the fibre and carbohydrate in oats...
  18. Russ H
    An article by Eric Topol discussing the technique: https://erictopol.substack.com/p/an-exciting-new-approach-to-autoimmune
  19. Russ H
    Have already completed safety trials in people with coeliac disease. https://www.eurekalert.org/news-releases/1001177 The actual paper in Nature: https://www.nature.com/articles/s41551-023-01086-2
  20. Russ H
    I tried it again yesterday, with similarly good results. Even though is has whole grain flours, it tastes more like a white bread pizza. It is not too complicated to make. The same website has some excellent bread recipes but they have lots of ingredients and are quite involved to make even with a machine to do the kneading and baking.
  21. Russ H
    That is why it took so many years for the cause of coeliac disease to be elucidated - most people don't react immediately to gluten. If you have a food allergy, you know immediately what you are reacting to. With coeliac disease it is a very delayed and drawn out immune response.
  22. Russ H
    I have tried this recipe a couple of times, and it is fantastic. The dough is very much like wheat-based dough - you can roll it and stretch. It makes a fantastic base, just as good as any wheat dough pizza I have tried. It is based on gluten-free oat flour, millet flour, tapioca starch and psyllium husk. I didn't have any millet flour, so substituted with...
  23. Russ H
    Interesting. I found an article from Stanford Medicine that describes OAS well. Apparently most sufferers don't react to cooked fruit as it denatures the proteins. https://stanfordhealthcare.org/content/dam/SHC/clinics/menlo-medical-clinic/docs/Allergy/Oral Allergy Syndrome.pdf
  24. Russ H
    I used to have a couple of house bricks under each leg at the top of my bed. Any more than that and I used to slide off the bed in the night. Luckily my reflux has disappeared now. There's an article about reflux and asthma here: https://www.everydayhealth.com/asthma/symptoms/surprising-connection-between-gerd-asthma/ Thanks...
  25. Russ H
    From the article I have used it without problem. It is just a polysaccharide. If significant proteins came through from the feedstock, it would trigger allergic reactions and this doesn't happen.
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