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Russ H

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Celiac.com - Celiac Disease & Gluten-Free Diet Support Since 1995

Everything posted by Russ H

  1. Russ H
    Even if it reduces symptoms, it does not treat the underlying pathological immune response.
  2. Russ H
    I think some of the terminology is wrong. Rather than 'testing positive', I think it is better to say 'having raised antibody levels'. We seem to be going around in circles in this thread. It is true that raised tTG2 antibody levels can be caused by other conditions, particularly involving inflammation of the bowel, liver or joints. However, very high...
  3. Russ H
    EMA is just tTG2 with a high threshold. It detects the same antibodies just more crudely. Moderately raised tTG2 can be caused by other conditions but when the tTG2 antibodies are at least 10x the reference range, that is almost certainly coeliac disease. This is in essence what the EMA test is doing.
  4. Russ H
    It happens with primary teeth but should not happen with secondary teeth.I found a case associated with coeliac disease but it seems to be very unusual and possibly associated with vitamin D deficiency and mineral metabolism. https://pubmed.ncbi.nlm.nih.gov/29335688/
  5. Russ H
    Genetic testing is useful to exclude coeliac disease, but I think the main thing is to pick it up with antibody screening. I was misdiagnosed for 22 years although I suspect I have had coeliac disease for 45 years. It is a horrible disease and the blood test is relatively cheap. Screening children and 1st degree relatives will catch most cases.
  6. Russ H
    Agreed. A good way to rule out most suspect cases. However, genetic testing is relatively expensive.
  7. Russ H
    That is wrong. If you follow up reference 8, you will read: The EMA test just detects tTG2 antibodies but with a courser and higher threshold. This is why it is more specific but less sensitive. It is not more accurate - it has fewer false positives but more false negatives. Further, coeliac antibodies - particularly anti-tTG2 - are produced by intestinal...
  8. Russ H
    None of those are for isolated IgG DGP. IgG DPG is useful for people who are IgA deficient or for infants under the age of 2, otherwise it has poor predictive value of several percent.
  9. Russ H
    Yes, but they didn't show the tTG2 antibody levels. The EMA test is a crude form of tTG2 antibody test. The study is basically saying that moderate tTG2 antibody levels are not always coeliac disease. You have 10x. That is not moderate.
  10. Russ H
    I would be interested to see these. Do you have the references?
  11. Russ H
    DGP on its own is fairly good at predicting coeliac disease but it would usually be accompanied by high tTG2. DGP with low tTG2 is not very predictive of coeliac disease. There is a larger study linked below which indicates a positive predictive value of 2.8% in paediatric patients for isolated DGP. https://www.sciencedirect.com/science/article...
  12. Russ H
    Yes tTG2 antibodies 10x the reference range is almost certainly coeliac. Add in stage 3 viillous atrophy and well... EMA also detects tTG2 antibodies but is an old and relatively crude and insensitive test.
  13. Russ H
    DGP is part of the standard coeliac blood screening panel. It gives a small increase in predictive value. The fact that the other 2 tests showed very low levels of antibodies combined with a lack of symptoms suggests that this is not coeliac disease.
  14. Russ H
    Isolated DGP IgG as in this case has poor predictive value (only a few percent). https://onlinelibrary.wiley.com/doi/10.1111/jpc.16071 Based on the results and symptoms, I think it is unlikely to be coeliac disease (although this does not rule it out).
  15. Russ H
    That sounds like a dysbiosis which is common with coeliac disease. You get bacterial overgrowth in the small intestine which produces gas and probably toxic by-products that get into the bloodstream. We call it SIBO (small intestine bacterial overgrowth). For people with coeliac disease it generally corrects itself on a strict gluten-free diet. Mine took...
  16. Russ H
    OK, so it does not sound like diabetes. Do you experience a swollen upper abdomen after eating and burping?
  17. Russ H
    And this occurs after you eat? Have you had your blood sugar tested? Do you experience bloating and burping after eating?
  18. Russ H
    I understand now. When you say ataxia, you mean that your have difficulty co-ordinating your muscle movements (such as difficulties with speech or walking)?
  19. Russ H
    Emanon, you need to have a blood test for coeliac disease. For this test to be accurate, you need to eat gluten every day for 6 weeks prior to the test. Can you get your doctor to give you a blood test? The test is for IgA tTG2 antibodies - it is an easy test to do.
  20. Russ H
    It is very common for adults to have neurological symptoms on diagnosis of coeliac disease. Most people show clinical improvement by a year, so be patient and adhere to a strict gluten-free diet. Take a good multivitamin for the first year at least.
  21. Russ H
    Hi IanL, Do you have coeliac disease, and is the bakery gluten-free?
  22. Russ H
    That is interesting. UV is also used to treat psoriasis that won't respond to other treatments.
  23. Russ H
    Hello lavranso4, Your don't say what your sex is. It is common for men with untreated coeliac disease to experience androgen resistance where the body tissues stop responding to testosterone. Typically people will show raised blood levels of free testosterone but reduced levels of dihydrotestosterone (DHT). There may also be increased levels of luteinising...
  24. Russ H
    It is quite common to experience neurological symptoms with coeliac disease, particularly anxiety and short term memory problems. I used to drink in the same way as it provides rapid relief from the symptom of anxiety.
  25. Russ H
    How do you mean basic screening? The basic test for coeliac disease is a blood test for IgA tTG2 antibodies. If you have chronic gastrointestinal symptoms, that should be reason enough for a test. Without units and the lab reference range it is not possible to evaluate the results you have supplied. I assume it is grams per litre, so it is high normal for...
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