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John Scott

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Celiac.com - Celiac Disease & Gluten-Free Diet Support Since 1995

Everything posted by John Scott

  1. John Scott
    dianabanana, yes, the Helminthic Therapy wiki can initially appear overwhelming, but it's an encyclopaedia that answers all questions about the therapy, so it's inevitably very detailed. However, there is an introductory page which sets out the basics and offers a way in to the rest of the site. Introduction to helminthic therapy It's interesting...
  2. John Scott
    There's more low-down on the survival of NA larvae in storage in the Helminthic Therapy wiki. See this section : Storage
  3. John Scott
    @Scott Adams It isn't about who knows more. It’s about being free to look at all the available evidence objectively and understanding all the factors involved, many of which are set out in detail at the following link. But, in order to understand this yourself, you do need to actually read the details. https://htwiki.mywikis.eu/wiki/Helminthic_t...
  4. John Scott
    @Scott Adams. Firstly, I do not sell hookworms! As I’ve told you privately in the past, I make no money whatsoever from helminthic therapy. What I have done is founded the Helminthic Therapy wiki, which is the world’s largest information database documenting the science, management, experience and results of helminth replacement, a form of probiotic self-tre...
  5. John Scott
    I'm re-posting the entire comment that I referenced above because I've noticed that some of the links in that earlier post have expired due to a site migration. The conclusion by the authors of the later of the two studies you mention above - Croese et al, 2020 (1) - that infection with NA does not obviate the need for a gluten-free diet is rendered...
  6. John Scott
    @knitty kitty, please see my previous post and subsequent comments about the 2020 study that you mention. https://www.celiac.com/celiac-disease/hookworm-infection-no-magic-bullet-for-gluten-tolerance-in-celiac-disease-r6096/?tab=comments#comment-23528
  7. John Scott
    OK, to be clear, my position is not quite the same as that of Croese et al. Rather than stating, as they have done, that "Hookworm infection does not restore tolerance to sustained moderate consumption of gluten…" , more careful researchers would have said that, "In our study, hookworm infection did not restore tolerance to sustained moderate consumption o...
  8. John Scott
    Last year, Venkatakrishnan et al, published a study with the following conclusion. "Unfortunately, for a variety of economic, regulatory, and practical issues surrounding the conduct of clinical trials, main stream trials have thus far been unable to accommodate the nuances of helminth therapy. Foremost among the issues that clinical trials must address...
  9. John Scott
    I am not recommending that the hosting of helminths should replace a gluten-free diet. My post, above, was only intended to draw attention to the fact that the conclusions of Croese et al cannot be relied upon, leaving the question as to how effective hookworms might be in addressing celiac disease still open. It is, of course, eminently sensible for...
  10. John Scott
    The conclusion by the authors of the study featured above - Croese et al, 2020 (1) - that infection with NA does not obviate the need for a gluten-free diet is rendered unreliable by methodological deficiencies in the trial design. The trial participants each received two doses of either 10x or 20x N. americanus (NA) hookworm larvae at weeks 0 and 8...
  11. John Scott
    The safety of long-term use of helminthic therapy has been demonstrated by the global community of helminth self-treaters. I, myself, have hosted Necator americanus for the past 14 years, after getting my first dose in a clinical trial at Nottingham University, and they have kept me free from Crohn's disease and several other conditions during the whole of...
  12. John Scott
    Necator americanus (NA) is extremely safe, as is explained in detail here: https://helminthictherapywiki.org/wiki/index.php/Helminthic_therapy_safety#The_safety_of_NA Unfortunately, most of the clinical trials that have been mounted to date to examine the therapeutic effects of NA have had serious methodological deficiencies, which are set out here...
  13. John Scott
    The safety of controlled infection with the hookworm, Necator americanus, had to be established before clinical trials with this organism could proceed, and was confirmed in studies at universities in the UK and Australia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728895/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050888/ In view of...
  14. John Scott
    @Scott Adams, I agree that criticizing the Croese et al study doesn’t provide scientific support for a claim that hosting hookworms can allow celiacs to regularly eat gluten, but that wasn’t my intention, or my claim. In explaining the methodological flaws in their study, I was merely pointing out that the conclusions drawn by these authors cannot be rel...
  15. John Scott
    @Scott Adams, I founded the Helminthic Therapy wiki six years ago to share the data I’d begun to gather on this treatment four years previously. I have no financial interest in the therapy and, in fact, it has cost me quite a lot of money, not only what I paid out for the setup of the website, and for its maintenance in the first four years, but also in i...
  16. John Scott
    Helminthic therapy is being used to treat over 160 different conditions, not just celiac, and, in the vast majority of cases, the self-treater knows that it's working when they start to feel better. At that point, the number of variables don't matter any more. Relief is sweet, however long it takes to appear.
  17. John Scott
    In this Croese et al, 2020 study (1), the trial participants received two doses of either 10x or 20x N. americanus (NA) larvae at weeks 0 and 8, and were challenged with gluten between weeks 12 and 42, with an optional 52 week extension for those participants without celiac disease symptoms. Based on the data, this trial’s authors stated the conclusion t...
  18. John Scott
    I doubt you will be convinced that the study was poorly designed when you admit to not having read the details at the link I gave you. I wrote that analysis of the reasons why so many trials using living worms are flawed, and I was careful to make sure that all the points made would be clear to anyone who actually takes the time to read them. Regarding...
  19. John Scott
    How the worms actually do it is quite complicated, and still not fully understood. One researcher who has been working on this for several decades has told me that the worms are particularly resistant to yielding up their secrets! For example, they excrete/secrete an entire "orchestra" of chemicals - at least 200 of them. Quite astonishing! What we do...
  20. John Scott
    That's what the study authors concluded based on the the data they obtained, but the trial design was flawed. Most of the clinical trials conducted to date have been seriously flawed because the researchers used methodology designed for testing synthetic drugs rather than living organisms. If you're interested, the problems with this and other similar trials...
  21. John Scott
    Yes, indeed, lifespans have of course increased dramatically since industrialisation, but, in removing our helminths, industrialisation has also robbed us of the essential immune modulation that worms provide. Restoring helminths to the gut of a helminth-deficient Westerner completes the machinery that was developed over millennia as a result of our...
  22. John Scott
    The Vikings weren't unique in hosting helminths. Everyone in the world had at least one type of helminth at some point during their lives up until their population became industrialised. Every archaeological dig finds helminth-rich coprolites - if they bother to look for them, of course. Ötzi, "the Iceman" had human whipworms (Trichuris trichiura) in his ...
  23. John Scott
    There are indeed people who are saying that hosting benign helminths has put their diseases into remission. There are many thousands of helminth self-treaters spread around the world who are enjoying vastly improved health as a result of replacing a few helminths. See the three studies listed at the following link. The rewards of re-worming
  24. John Scott
    I believe that anthelmintic drugs were introduced in the mid 1900s.
  25. John Scott
    The four species of worm used in helminthic therapy are, strictly speaking, all "mutualists", not "parasites" - a distinction not fully appreciated by many working in the medical field. Mutualism is a type of symbiotic relationship between individuals of different species where each organism benefits from the other. The four "therapeutic" helminths are also...
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