I have a pair of DQ1 genes. I've been gluten-free/CF for about 1 1/2 yrs. In addition to some gastro symptoms, I had peripheral neuropathy(PN) symptoms(numb toes/foot) before going gluten-free/CF. The gastro symptoms (bloating, gas, constipation) responded positively within a few days. The PN after about a year seemed to be be better, certainly no worse...