Posterboy

Open Letter to the many GI sufferers etc Part 1’ Like IBS, UC and other GI diseases like Infant Heartburn (GERD) that
grows into (in time) to IBS, UC, Chron’s and NCGS as a teenager or Celiac disease in time as an adult— Look Beyond these symptom’s
to the parent disease –- Pellagra.
 
*** a couple of notes to begin with.  You can see I meant this to be one post -- but as usual it got too long to read at one seating. 
2) because I might be having a medical procedure soon (I am posting part 1) in case I don't get to part 2 until latter.
****This is only my experience (and my research) that has lead me to my conclusions. They are NOT endorsed by celiac.com nor should this blog post
be considered and endorsement of these ideas by celiac.com.  Thank you in advance for letting me share my opinions and conclusions.
(God being my help) may this posterboy blog post benefit those who take the time to read them/it.  What follows is something that has been on my heart to share
for a while.  It is my story only. . . yours may be different but I have found if it helps you  . . . it will  help others too!  And as they say "Without Further Ado"
Here are my thoughts about my original celiac diagnosis and what/why I think was also low in stomach acid but a proper diagnosis was not
made because not enough/proper test's were done to rule it out as an official "differential diagnosis".  If it is happening to me. . . it is happening to others!
 
Below begins the body of blog post of "An Open Letter Part 1 to Fellow GI Sufferers"
 
Because as I am fond of saying “To Educate is to (Truly) Free”
God being my help 2 Timothy 2: 7 as always“Consider what I say; and the Lord give thee understanding in all things” this included
and all the knowledge I have absorbed in 10 years of researching this topic for myself (God being my help) how I discovered this forgotten
medical fact after 4 years  of research (see below) and have been helping people for over 6 years (those who will listen) and who better
to learn from than someone who has done it himself and not only for himself but 100’s of his friend too!
See this celiac.com article where much of this information is summarized in something called a white paper about the
“When Myth becomes Medical Fact People suffer unnecessarily; The Case of Mistaken Identity: How Pellagra now thought
to be rare became known as Celiac Disease — A White Paper linked at the end of the article.
Referenced here if you have not had a chance to read the article since it was featured on celiac.com
https://www.celiac.com/articles/24658/1/A-Differential-Diagnosis-How-Pellagra-Can-be-Confused-with-Celiac-Disease/Page1.html
“A white paper is an authoritative report or guide that informs readers concisely about a complex issue and presents the issuing body’s
philosophy on the matter. It is meant to help readers understand a (complex) issue, solve a problem, or make a decision.”

 By reading this blog post I hope to convenience you that your experience can be the same as mine.
A differential diagnosis is one of  the best standard of medicine rarely practiced today and how specialists decide between competing
diseases like UC or Chron’s or IBS or Celiac Disease and if I am right Co-Morbid Pellagra now forgotten for 75+ years since the “War on Pellagra”
is now over according to medical professionals’ but sadly the battle rages on for at least for the 60 Million American’s alone who get
(Infant) Heartburn  once a month not counting the heartburn that grows up to be IBS, UC, Chron’s or Celiac disease.
See link below from Creighton University that mention’s this medical fact.  Pellagra is not a disease of TODAY.  Celiac is the disease
of Choice today!  But in 58% of those diagnosed with Celiac TODAY 58% are Co-Morbid with Pellagra as I was and most ALL my friends
because they ALL get better when they take the Niacinamide.
I now it works. I have seen it work for too many people. And I believe it can/could work for you too!  See end of this blog posts
and my doctor does too.  He now uses this method in his practice with great success!  And it can work for you too! (I believe)  
Lord willing if you do as I suggest and take Niacinamide 2or 3/day for 6 months (see below).
I now describe myself as the Celiac and Pellgara Posterboy as a “Former Celiac Sufferer” who blogs about digestive disorders
that Co-Morbid Pellagra causes often presenting as other GI diseases like IBS, UC, Chons, NCGS and GERD”
Note **** This IS NOT medical advice only my personal experience of how through deep research (and the Grace of God) after 4 years of study
I found what the doctors have always known but overlook in treating the many symptoms of Celiac Disease. The true cause as recorded
in medical textbooks the world over the cause of 90+ percent of Digestive disorders (I believe) is because of one Vitamin Deficiency/Dependency.
This blog post and (Posterboy blog) is about that ONE nutrient/vitamin/mineral that is lacking and the causative agent for most Digestive Disorder(s)
presenting as the Iceberg Disease(s) of Gluten Insensitivity aka Celiac Disease in its most advanced stage (with enough time).
And I hope at least ONE other Celiac besides me will believe also and be helped from this post.
As proven/researched by Prousky almost 17 years ago that low Niacin levels lead too low stomach acid.  It is time this information was
known by a wider audience – the Celiac audience.
Open Original Shared Link
see also by posterboy blog about this topic. It is a devastating delay.
2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included.
When Celiac Disease points it head (rears it head) out of the water 20+ symptoms (known as associated diseases) have already presented
themselves in various malady’s. When only 3 (the 3 Ds) symptoms  where need 75 years ago to diagnose the condition once considered
cured but is rampant in today’s society because we are more STRESSED than ever.
Digestive disorders, dermatitis syndromes, and dementia disorders – known then as Pellagra 75+ years ago but now is known mostly
as various GI diseases depending on how long or low you are in Pellagra Preventive Factor as it was called in the day.
Here is the best research article I have ever read on the topic.
Open Original Shared Link
They called it “Lessons from Pellagra” but the problem is we haven’t learned them.
What does this look like in human beings?
If one is critically low in Niacin the 3 D’s of Pellagra (Dementias, Dermatitis’s, and Digestive Issues) show up.
(see hindawi link about for the exhaustive complete diagnostic picture of all the ways Pellagra might present itself. 
It is very exhaustive and informative) We will not count the 4th D of death if you are reading this blog.
Explained here well Open Original Shared Link
To quote Dr. Heaney a Past Professor of Medicine at Creighton University “2014 marks the 100th anniversary of the war on Pellagra,
a war that lasted nearly 25 of those years before victory could finally be declared. You have not heard of the war on Pellagra?
The celebration is not on your calendar? You’re not alone.”
I have been in remission now for 5+ years after suffering 30+ years. Remission is possible! From Pellagra!
Epigenetics has been discovered as the cause for Pellagra being diagnosed as Non-Celiac Gluten Sensitivity (NCGS)
or Celiac disease when Heartburn/Gerd then IBS etc. and NCGS in time grows up to become your Celiac Diagnosis.
Learn how Lifestyle (STRESS) is a risk factor for Celiac Disease.
see this article entitled ‘Lifestyle is a Risk Factor for Celiac Disease”.
Open Original Shared Link
Quoting an article that appears on Celiac.com
https://www.celiac.com/articles/24166/1/Could-Changing-Gut-Bacteria-Prevent-Celiac-Disease/Page1.html

“According to Dr. Decker Butzner, a Calgary-based pediatric gastroenterologist, there are another triggering factor which we’ve
never understood…[t]here is an environmental trigger.“ i,e.  STRESS
Have you been stressed of late?  Stress is said to kill you well it also maims you.  NCGS is that maiming of people who have eaten
wheat without resetting their stress clock.
Find out how you can reset your stress clock (my words).
Also see this very well article on pregnancy.
Open Original Shared Link
where they say quoting
First Comes Baby, Then Comes Symptoms
"Most women are diagnosed with celiac disease after at least one pregnancy — in fact, a comprehensive Italian study
published in 2010 on the reproductive effects of celiac found that 85.7% of women received their celiac diagnosis
following their first pregnancy."
WE also know stress is a trigger for Celiac disease.
https://www.celiac.com/articles/23506/1/Stress-Common-Before-Celiac-Diagnosis/Page1.html
Join his friends who no longer suffer from heartburn, gas, constipation, diarrhea, IBS , UC, Chron’s and Ulcer’s etc. of NCGS/GERD.
You too can be in remission in as little as six months if you follow this ground breaking discovery hidden in medical text books
now brought to light about how to manage digestive stress from Pellagra.
When he (God being his help) rediscovered Pellagra as a disease of TODAY now often Diagnosed as Celiac disease instead of one conquered 75+ years
ago as the doctors teach.
A brief history: over 4+ years ago after being able to eat gluten again after being Gluten Free for 4 years and suffering 30+ years
before I received a diagnosis as Celiac disease I begun to realize I had low stomach acid instead.
So now I speak about it freely and blog about it regularly with only modest success and why I participate on celiac.com to Educate
those still suffering unnecessarily to help explain how Pellagra is often confused for many GI issues up to and including Celiac Disease in time
– usually 10 years or more.
*** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any
changes to your diet or your prescribed medical regimen.
After 4 years of research and 5+ years of GI symptom remission I am convinced more than ever that 90+ percent of the most common
GERD/Gluten issues are related to sub-clinical presentation of Pellagra unrecognized in a clinical setting.
So much so that I tell those who will listen.
As I am fond of saying  Learn from my mistakes.
Honey is like knowledge sticky and sweet when good news comes.
“This posterboy blog is just that storehouse of knowledge learned from life experiences.  The blog’s author has been stung so you don’t have to be.
No man is so dumb as the man who won’t learn from other people’s mistakes.
Take as much honey (knowledge) as you can from my mistakes so bad health will not sting your quality of life.
Feel free to ladle and dollop your life with the sweet stickiness of the truth found here.  For honey like truth stick to you once
in contact and you can’t just wash it away.”
This posterboy blog is about my struggle to reach people yet only about 10 percent believe and are helped when they read these things
though 95+ percent are helped when they treat their Pellagra symptoms with Niacinamide taking it 3 times/daily for 4 to 6 months.
Education (this blog) is about raising the conversion rate so people don’t have to suffer any longer.
I will go on telling those who will listen. How can they hear if no one tells’ them?
Romans 10:14 (I speak as a man)
Tell others about this blog post if you decide to try Niacinamide for yourself and see If it helps you.
It will help others/them too most likely!  At least it helps most of my friends that will/have believe/believed and tried it for themselves.
Take the Niacinamide and get/be better in 6 months (begin BURPING) (w/o bloating I might add) for the first time in years IF EVER from Pellagra undiagnosed.
No one seems to believe (or at least not many) becoming deficient in (a) vitamin or vitamin(s)/minerals will/can make us sick.
What a novel concept. You would not think I would need to write a blog post to tell people that!
Maybe it is not true in your case. But you won’t know if you don’t try it.
All I know it has been true in my life! and Hundreds’ and hundreds’ of my friends.
Thanks bee to God who helped me to see these things.
2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort;
4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we
ourselves are comforted of God.”
Tell someone (share) is all I ask  tell others is all I ask –when you are BURPING for the first time in years or (EVER) – tell a friend
about this blog post “is all I ask” but don’t let the chain break with you. There a lot of fellow sufferers’ who still need help.
I always say the number one mistake people make with Niacinamide is not taking it long enough (3 to 6 months 3/day in divided doses)
but now I am going to amend that.  The number one mistake people make with GI problems is the mistake of not taking the Vitamin
in the first place.  The 2nd biggest mistake is they don’t take it long enough!
If you want to try and educate your doctor/friends and think he/she/they will listen tell them how Niacinamide helped you
or some fellow who says it helped him but I was too scared to try it.   Maybe they will listen to your better than they will/do me.

*** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making
any changes to your medical regimen.
But mine has taken Niacinamide and his digestive/GI problems are in remission.  And his difficult to help/treat patients who
don’t respond to “popular” medicine’s like Linzess etc. are better for IBS-C.  And have stopped the medicine because their
symptoms are in remission.
He has even given Niacinamide to his sister to help her Chrons symptoms’ though research bears this out people don’t
(Heck doctors don’t even) well understand the connection.
See this article entitled “Pellagra as the presenting manifestation of Crohn's disease.”
Open Original Shared Link
(***Note: this is an update.  I saw my doctor recently and he admitted as such. But I could see it in his eyes (and hear it in his voice)
because it did not fit his paradigm (world view of Vitamins/medicine) he spoke only of her Chron’s being in remission.  It never occurs too
him that her co-morbid Pellagra is better and it (Pellagra) could be being misdiagnosed as Chron’s instead (and won’t/wouldn’t) even
if I brought him the research.) 
But Vitamin(s)/Minerals especially Niacinamide and Magnesium don’t get the attention they deserve because Vitamins’ don’t have a
USP today in this genetic age we now live in.
They (drugs) are popular because they have drug companies who have the money to advertise them.
I do not.  I do not have a Unique Selling Position (USP).
Nor do Vitamins these days!
And I say too you too.  Put your Pellagra symptoms into remission too!  (Your Celiac diagnosis can remain your primary disease diagnosis) as the
doctor's wonder why your (Pellagra misdiagnosed) symptom's are in remission.
No body profits if you get better in 6 months or a year and you no longer need the Vitamin!
We don’t’ get sick from being low in “a Medicine” to quote the frustrated pharmacist but a Vitamin.
I usually end up giving Niacinamide away and often they (friends) give it back instead much like a Johnny Appleseed character.  
Such is the fear of Vitamins these days.
See also the posterboy blog post on celiac.com why this is so. . . entitled it is time for a Vitamin Reformation; Why all the hate for Vitamin’s these days.
2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included.
I am just trying to help those who still haven’t heard yet Pellagra is being diagnosed as Celiac disease today and your Pellagra
undiagnosed/mistakeningly diagnosed as Celiac can be in remission from a Vitamin deficiency.
If we follow most normal paths’ for adoption it will take another 20 years (a generation) for the medical community to accept
Pellagra as the proper diagnosis.
****Note: I am only reporting what medical journals have concluded. It is just not well understood today one disease is being diagnosed
as the other because it can take a generation for this knowledge to filter down to the clinical level.
How do we know this??? Or can we? The International Journal of Celiac disease notes this association/connection.
Open Original Shared Link
Not only did/does the Journal of Celiac cite common symptom’s 58 percent of the time in Celiac and Pellagra but they also cite
that Pellagra has been described in a Celiac Disease diagnosis.
Now if the symptoms’ are similar it is easy to confuse one disease for the other and if not well understood they might be considered
“exceptional” or, i.e., not well understood and discounted as the cause.
I would argue that it should be the other way around if the majority (58 Percent) of the time Pellagra symptoms are described in a Celiac
diagnosis it stands to reason that medical science is identifying the wrong disease.
The math doesn’t add up. 58% is the Majority  (primary/parent) disease and as such should be treated first.
Pellagra has 3 faces that often confuse doctors today but 75 years ago they were able to diagnose this disease with only 3 symptoms
the D’s of Pellagra. Dementia’s, Digestive Disorder and Dermatitis issues. Are You starting to see a pattern here?
If it starts with a D then Pellagra a Niacinamide deficiency is involved. Quoting the Celiac Posterboy
“These D’s a Celiac patient encounters are not the sign of several different diseases but one parent disease Pellagra with many children.”
I could go on and on and on . .. but there is no need for that. I need to stop for now.
Either you will believe and be helped or go on suffering needlessly if indeed Pellagra is the parent disease and GERD, IBS, UC, Chrons, NCGS
and Celiac disease it‘s unruly children.
2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort;
4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith
we ourselves are comforted of God.”
****Again this is not medical advice but it is too easy, simple and cheap not to try and see if it works for you . . . I have found it works for others.
Remember Occams’ Razor. . . The Simple answer is a Vitamin. But convincing people of that fact has not been simple or easy.
I can’t convince you either way. You will have to decide for yourself . . . I only know it help’s those (of my friends) who have tried it for themselves.
Praise bee to God and I want other’s still suffering from Pellagra disease if the research is to be believed being diagnosed as Celiac
disease to be the next to be helped Praise bee to God!
But I know now you will have to discover it for yourself. I stand as your witness. I tried!
Posterboy by the Grace of God,
 
2 Timothy 2:7  As always, “Consider what I say; and the Lord give thee understanding in all things” this included.
 
**** I will update this blog post in a month to 6 weeks with Part 2 about how you can test these things for yourself (if I am not recovering (God forbid) from
a medical procedure) depending on how and if my CT scan shows any blockage that might require a stent to be implanted like my brother had to have done. . . 
Otherwise I wish you all who read this posterboy blog post God speed!  And good GI health soon! Praise bee to God if you are encouraged enough from
this post to try the Niacinamide 3/day for 6 months for yourself.

I went through very similar symptoms, being misdiagnosed and told it was all in my head for most of my life.  It's not all in our head.  It's what's NOT in doctors' heads.  Doctors don't think of vitamin deficiencies as causes of symptoms like we have.  Doctors are trained to prescribe pharmaceuticals in medical institutions funded by pharmaceutical companies.  
I've experienced the limbs falling asleep.....
Vitamin B12 deficiency neuropathy; a rare diagnosis in young adults: a case report
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5273828/
And...
I've experienced gritty dry eyes and eye pain, light sensitivity....Optic nerve swelling and permanent vision loss occurred in my situation because of delayed diagnosis...
Vitamin B12 deficiency evaluation and treatment in severe dry eye disease with neuropathic ocular pain
https://pubmed.ncbi.nlm.nih.gov/28299439/
And...
Tinnitus and hearing loss...
Therapeutic role of Vitamin B12 in patients of chronic tinnitus: A pilot study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918681/
And...
Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039400/
 
My "friends" used to call me  Helen (as in Keller) because I had such bad problems with my hearing and vision... I was referred to the Helen Keller Institute for the Blind hospital and even those specialists did not diagnose B12, Vitamin A, and Thiamine deficiencies causing my vision problems.  
I have Bell's Palsy, a type of facial numbness and paralysis, which is linked to B12 deficiency.
I have had dark circles around my eyes and puffy eyelids from B12 deficiency.  
B12 deficiency caused urination urgency problems.
I experienced facial rash, nail, and hair changes...
Cutaneous lesions and vitamin B12 deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2294086/
 
Niacin B3 caused nail changes, especially toe nail changes that look like fungus but it was the start of Pellagra.  I had Casal's necklace, and the doctors still did not diagnose the Niacin deficiency.
Magnesium deficiency caused night terrors.  Iron deficiency caused black lines in my nails.  Riboflavin deficiency caused a rash around my nose and mouth.  Vitamin C deficiency caused skin problems and hair loss.  Thiamine B1 and Biotin B7 deficiency contributed to hair loss.  Thiamine deficiency caused panic attacks and eventually Wernicke's Encephalopathy. 
Big Thing to note is we can have B12 deficiency symptoms BEFORE blood tests show B12 deficiency.  Same for the other vitamins.  Blood tests don't accurately reflect vitamin deficiencies inside the organs and tissues of the body where the vitamins are actually used.  Blood tests for vitamin deficiencies can reflect how much of that vitamin we've consumed in the previous twenty-four to forty-eight hours.  Supplementing with vitamins prior to blood tests for vitamin deficiencies will reflect the vitamin supplements, not the deficiencies in organs and cells.  
B12 deficiency can be reversed by oral B12 supplementation or B12 shots, but remember, it's unusual to have a single vitamin deficiency in Celiac Disease because the absorption of vitamins and minerals are affected by damage done to the small intestine where most vitamins and minerals are absorbed.  
There are eight essential B vitamins.  Our bodies can not make these or store them for long, so we need to consume them every day.  The eight B vitamins all work together, dependent on each other.  B12 needs folate B9 and pyridoxine B6.  Pyridoxine needs riboflavin B2.  Thiamine B1 and Niacin B3 provide energy and enzymes for the other vitamins to work, along with magnesium and iron and other minerals, and Vitamin C. Also, there are four fat soluble vitamins we need, Vitamins A, D, E, and K 2.
Checking for nutritional deficiencies is part of proper follow up care for newly diagnosed Celiacs.  Blood tests do not accurately measure vitamin status, so talk to your doctor about supplementing with vitamins.  Talk to a nutritionist about including nutrient dense foods in the gluten free diet.
Hope my experiences with vitamin deficiencies can help you and others.

I can’t believe it now at 52 years old I know at long last the thing that I was always told was good for me was actually not, it was making me ill and I continued all these years putting up with Hives when I was younger, and then bloating, wind and slight bladder incontinence, Fibromyalgia, tingling and numb fingers (Carpel tunnel Syndrome )) overweight even though I didn’t eat excessively and all because of Lactose. It is hidden in so many things not just milk, it’s in medication, Gravies, packet soups, Lagers and so many other things but they do not list it in the ingredients, so I hope that will change soon, I’m wondering if Lactose is the underlying problem with Celiacs and then maybe Gluten reacts because of the damage Lactose has done, Who knows. My symptoms all go away if I stay way from Lactose but if I have it they return so I know I can’t have it, I wish I knew this years ago.

How Low B Vitamins can Trigger a Celiac diagnosis and be Mistaken for a Genetic Disease
To Whomever May Read This,
(Thank you for taking the time to read it and I hope it helps you the way it did me! and if it
does tell others....is all I ask)....because I know there are many more fellow sufferers still looking for answers...
(because many/most B-Vitamin deficiencies up to 80 percent of the time (especially a Thiamine Deficiency)
is going undiagnosed or misdiagnosed in other diseases)....and probably a Riboflavin Deficiency too because they occur together....
Read the blog post and you will see what I mean....
Note: this Posterboy blog post will have 2 portions…. A high level summary and an Appendix/Addendum list of available
resources that support these suppositions…
Depending on whether you have read the other Posterboy blog post(s) will determine how you want to read this one….
If this is your first then read it all…IF you have read other Posterboy blog posts…then just jump to the Appendix where
the references/additional resources are….and all the dirty details...
The Posterboy blog post starts now…entitled "How Low B Vitamins can Trigger a Celiac diagnosis and be Mistaken for a Genetic Disease"
For a while now (10 to 12+ years now)…..I have been studying B-Vitamins to see what role if any they (B-Vitamins) might
have in regulating our Immune System and if they could be the trigger for my GI problems or could have been mistaken
for my Celiac disease diagnosis….
Note: I did not say my Celiac disease….but my diagnosis as a Celiac….see Appendix for other possible triggers.
I had written two previous articles/Posterboy blog posts one about Thiamine (Beri Beri) aka Vitamin B1 and
one about Niacin (Pellagra) aka Vitamin B3.
Provided here for easy reference.....if you want to go back and read them sometime...
Both play a critical role in our immune system and down regulate inflammation pathways in the body…
This Posterboy blog post/article unites the two into an "Elegant Theory" of how and why these occur together in Celiac disease.
I had previously done an unpublished article/blog post on Riboflavin….which I might share in the future (but probably not at this point)
This Posterboy blog post will serve as the argument (thesis) that Riboflavin deficiency is common in Celiac’s going commonly undiagnosed/misdiagnosed….much like the other B-Vitamin deficiencies of Thiamine (B1) and Niacin (B3) in Celiac’s.
I have now found that it is a cascade of all three of these B-Vitamins and maybe 4 (beyond the scope of this blog post Vitamin B6)…..
B1, B2, B3 work synergistically together to control inflammation in the body.
I found first that Pellagra could be common in Celiac’s going undiagnosed/misdiagnosed….
Then I found that Beri Beri might also be the reason for Celiac’s thin Villi….
SO I had to write about it/that too!.....but no ONE Vitamin/Mineral answered all the questions….
So that made me think I could be wrong about the Pellagra question (in part) at least…
IF there is NO SKIN issues IE DH with your Celiac diagnosis then you have NOT YET developed Pellagra….
but more appropriately Pellagra Sine Pellagra…..or Pellagra without skin issues….
And brings me to the point of my current Posterboy blog post.
I believe that most Celiac’s have developed Pellagra Sine Pellagra.
Now granted they developed Beri Beri FIRST….because B-Vitamin deficiencies NEVER happen alone….
It (Celiac disease) is a sequalae (aftermath) of B-Vitamin deficiencies…and possibly some Minerals like Magnesium
and Zinc and Copper etc….(Again beyond the scope of this post)
See this Posterboy blog post to see how nutrients (IE Vitamin and Mineral Deficiencies), Genetics and your Environment
(STRESS) interact…. To produce disease…
So how did I arrive at Pellagra Sine Pellagra instead of Pellagra or Beri Beri (only)….
Because you definitely develop Beri Beri (FIRST)…..why not continue on the Pellagra tack…
There is a couple of distinguishing features between the two most notably the level of SKIN involvement….
Pellagra is a very VISUAL disease…..IF you don’t have DH or other Skin problems then you have not yet developed Clinical Pellagra….
But Pellagra Sine Pellagra a Riboflavin deficiency has all the same symptoms of Pellagra without the pervasive skin issues…
Make no mistake about it….I had already developed Beri Beri first (horrible fatigue) and Peripheral Neuropathy etc….
They typically occur together…..because as noted earlier B-Vitamin deficiencies don’t occur alone…
ONE will affect the others…
And why I landed on B2 (Riboflavin) instead of B3 (Niacin)….
The 2nd clue was the pervasive Iron deficiency issues most Celiac’s develop.
Is Notable that Iron Deficient Anemia aka IDA is very common in Celiac’s…
And people have forgotten how Riboflavin aka Vitamin B2 plays an important role in Iron deficient anemia…
https://pubmed.ncbi.nlm.nih.gov/31318024/
Riboflavin deficiency individuals often have fertility problems as well…
I too had these same problems that got better after Riboflavin supplementation…
Riboflavin again aka Vitamin B2 can cause people to have Hypothyroid problems…..which again was me three….
got better after Riboflavin supplementation…
Reason number 4) Anxiety can be the first sign of a Riboflavin deficiency check that one off too!
Reason number 5) Riboflavin is the trigger for a Homocysteine problem…..commonly diagnosed as MTHFR Gene defect….
https://chrismasterjohnphd.com/blog/2019/02/26/mthfr-just-riboflavin-deficiency/
Check, Check, Check, Check, Check….I had all the signs of a Riboflavin deficiency and the doctor’s missed them ALL!
Not to mention the hallmark angular cheilitis (Leaky Lips) for years…..and the doctor could only recommend for/to me was
to stop leaking my lips sooooooo much!
ALL this symptom’s and more got better after supplementing with Riboflavin….
SO that is why I know Pellagra Sine Pellagra happened to me and is also happening in other Celiac’s going undiagnosed/Misdiagnosed.
The Iron Deficient Anemia…..can be treated (in many if not most cases) with either/by treating your Low Stomach Acid or
by taking Riboflavin and/or Copper.
See this research entitled “Is achlorhydria (No Stomach Acid) an (independent) cause of iron deficiency anemia”
https://pubmed.ncbi.nlm.nih.gov/25994564/
The answer was a resounding yes!
So, I had developed low/NO stomach acid as the trigger for my Celiac/NCGS diagnosis…
AND just what another intrepid research discovered/studied 35+ years ago and was promptly forgot and
never believed….the more things change…the more they stay the same!
See this research entitled “Gastric morphology and function in dermatitis herpetiformis (DH) and in Celiac disease”
https://www.ncbi.nlm.nih.gov/pubmed/3992169
That should be the end of the discussion…..but It won't be....while their patients suffer...they will do more studies about it!
Quoting the whole abstract for emphasis!
Abstract
“Gastric acid secretory capacity was evaluated in 116 patients with dermatitis herpetiformis by means of the pentagastrin test.
Endoscopic gastric mucosal biopsy specimens were obtained from both the body and the antrum in 90 of them.
Forty-eight patients (41%) had a maximal acid output less than 10 mmol/h, and 30 of them (26%) were achlorhydric. T
he frequency of achlorhydria increased with age, and 27 out of 58 patients (47%) more than 50 years old were achlorhydric.
Antrum-sparing chronic atrophic gastritis was present in 92% of the achlorhydric patients, and hypergastrinaemia and
serum parietal cell antibodies were found in most of them. The prevalence of chronic gastritis of the body and of the antrum
increased with age. There was no correlation between atrophic gastritis or achlorhydria and small-intestinal villous atrophy,
the results of the D-xylose test, and blood folate and serum zinc determinations. The transferrin saturation index was lower
in patients with achlorhydria. The frequency of achlorhydria was significantly higher in patients with dermatitis herpetiformis
than in 69 patients with celiac disease.”
Note: 90+ percent of Celiac’s have NO stomach acid (at all)….this is not counting the percent of Celiac’s where just
Low in Stomach acid….mind you
This was not in NCGS but a study of Celiac’s who were already diagnosed as Celiac’s….
But EVEN this is not enough to get some people to believe!!!!
The research is out there…..this is a Classic example of Co-Morbidity….IE a Sequelae of one condition triggering the other!
The aftermath of B-Vitamin and Mineral deficiencies of Zinc, Magnesium, B1 (Thiamine), B2 (Riboflavin), B3 (Niacin) and
possibly Copper is being diagnosed as NCGS and/or as Celiac disease diagnosis IMHO!
It is my hope by sharing this old research rediscovered that at least ONE other person will believe me (YOU) and be helped!
Use a Celiac disease diagnosis as the way back. . . . not the end of the road for your health but the beginning of your way back to health!
As the I have the Lord being my help!
As I am fond of saying “To Educate is to truly free!” Where there is a free exchange of knowledge there is health and
peace for one’s soul and body!
So, what can I do NOW about this know that I know B-Vitamins might help my Celiac diagnosis?
There is “No Formula” but this is the best advice I can offer you.
Take a B-Complex AND a Benfotiamine (Fat Soluble B-1) or other Fat Soluble B-1s like AlliThiamine or
Lipothiamine (harder to find) AND a Magnesium Citrate (with meals) or Magnesium Glycinate (anytime)
2x to 3x a day (with meals) for 3 to 6 months.
(IF you are not taking an acid reducer like a PPI or H2 Blocker (better of the two kind with less long term side effects) )
you will begin to burp continuously even up to 2 hours after you have finished your meal…..
and between meals with the smallest snack… producing the biggest BURPS you have had in years, and years.
Don’t stop for at least 6 months….don’t stop taking them when you begin burping (again without bloating/gas distension)
BUT continue for 6 months till BURPING without these other symptom’s and a regular movement will become your new normal.
You are now again digesting proteins in your diet triggering a food allergy.
What I didn’t know at the time was that Pellagra is a “Capstone” diagnosis and not the “Cornerstone” disease.
Pellagra is definitely happening in Celiac’s because Tryptophan has been shown the ability to be a therapeutic for Celiac’s.
See this research about it… https://www.eurekalert.org/pub_releases/2020-10/aaft-tri101920.php
Here is another article about the same research indicating Tryptophan as Therapeutic treatment for Celiac’s…
https://www.news-medical.net/news/20201023/Intestinal-microbiota-offers-new-prospects-for-treating-celiac-disease.aspx
Confirming that when you develop “Leaky Gut Syndrome(s)” you have developed Pellagra.
But Pellagra does not happen alone and is not the trigger….it is the combination of multiple B-Vitamin deficiencies beginning
with Low Thiamine (B1), then Low B2 (Riboflavin) and finally Low Niacin (B3) aka Niacinamide presenting as DH in Celiac’s…
I did not develop Pellagra but Sine Pellagra instead!
Note: as to not overpower the reader (you) with too much information see addendum/appendix for more
reference’s resource where you can read to your Heart’s content (as much) or as little as you need to help you understand
these “Lost Connections” explaining
how the Chicken came before the Egg (Diagnosis). First you develop Low B-Vitamin deficiencies (IE Thiamine deficiency
or undiagnosed Beri Beri) THEN your Villi Thin and THEN you develop Pellagra Sine Pellagra a Riboflavin deficiency
leading (in time) finally to a/your Celiac diagnosis!
Also Note: SIBO and Cows Milk Protein IE Casein (not Lactose as is commonly believed) might also be a problem for you.
See the Appendix for more details.
2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.
I hope this is helpful but it is not medical advice.
Posterboy by the Grace of God,
ADDENDUM/Appendix
Resources
Thiamine the Overlooked Vitamin That Improves Autoimmune Disease And Autonomic Dysfunction
https://awaken.com/2021/02/the-overlooked-vitamin-that-improves-autoimmune-disease-and-autonomic-dysfunction/
The issues/symptoms of a Thiamine deficiency hide in other diseases….
It is only suspected (tested) for in diseases with high clinical suspicion such as Alcoholics and Anorexic’s etc….
Also here is a nice overview of how to recognize a Thiamine deficiency…
https://healthprep.com/articles/fitness-nutrition/guide-symptoms-thiamine-deficiency/#:~:text=Weight loss may occur in a thiamine deficiency,individuals called AMP-activated protein kinase (AMPK) becomes impaired.
Here is the best thread on a Thiamine deficiency and its many presentations/faces/symptoms on Celiac.com
for more resources on Beri Beri in GI diseases like Celiac disease and IBS etc.
Recently Celiac.com wrote an article linking AnitGAD antibodies to Celiac disease.
So that set me out to see if there was a link between Gluten Ataxia and AntiGAD antibodies….
And it turns out AntiGAD antibodies are diagnostic confirmation of a Thiamine deficiency in Celiac’s manifesting themselves as Gluten Ataxia…
See this research that explains the connection… entilted “Wernicke's encephalopathy: an excitotoxicity hypothesis”
https://pubmed.ncbi.nlm.nih.gov/9346467/
This confirms exactly what is happening in other GI diseases like UC and Chrons.
See this research entitled "Wernicke Encephalopathy in Crohn's disease and Ulcerative Colitis"
https://www.sciencedirect.com/science/article/pii/S0899900721000447
AS if often the case in WE the treatment is too little too late….let's not let the same thing apply/happen to Celiac disease patients too!
IF the research on UC and Chrons’ is to be believed Low Thiamine level’s can be a predictor of disease severity and recovery.
NOW a similar study needs to be done to confirm my many years of research proving once and for all….
A Thiamine deficiency is the trigger for Thin Villi!
Note: The Hormones Matter website is the best Thiamine resource on the web….and EON Health is a close second.
Zonulin a Marker for Niacin deficiency
Links/Resources https://alobar.livejournal.com/2930798.html#%2F2930798.html
Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine: Trp enhanced tight junction protein ZO-1…
https://www.researchgate.net/publication/312962348_Dietary_Tryptophan_Enhanced_the_Expression_of_Tight_Junction_Protein_ZO-1_in_Intestine_Trp_enhanced_tight_junction_protein_ZO-1
Dietary l-tryptophan alleviated LPS-induced intestinal barrier injury by regulating tight junctions in a Caco-2 cell monolayer model
https://pubmed.ncbi.nlm.nih.gov/30977499/
Intestinal permeability IE Leaky Gut and oxidative stress in patients with alcoholic pellagra (reversed with Niacinamide)
https://pubmed.ncbi.nlm.nih.gov/16713031/
Which is what the latest research confirms Tryptophan can be used in Celiac’s to heal Villi
https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx
Does Going Gluten Free Provide Relief or All Celiacs? The answer is NO!
https://medicalxpress.com/news/2021-02-gluten-free-diets-cure-all-celiac-disease.html
And why I recommended B-Vitamins as an adjunct treatment for Co-Morbidities that happen in Celiac’s.
This a complimentary approach. See this Posterboy blog post that discusses the B-Vitamins that might help treat a Celiac diagnosis
About 40 pct of Celiacs are NOT helped when they go gluten free.
This is about what else someone can do that is still triggering Villi blunting when eating gluten fee is not enough to heal your Villi???
Three or four of the most common triggers (IMO) for continued GI inflammation (Issues) in IMO are
Milk (Cows’ Milk Protein) aka CMP in the literature.
See this great Celiac.com article about how Milk in peoples diet can also trigger Villi Blunting…
A reaction to Cows Milk Protein (Casein) can happen in up to 40 percent of Celiac’s…
See this nice study on the issue of Caseins’ also triggering an Immune response in Celiac’s
Entitled “IgA anti-gliadin antibody immunoreactivity to food proteins IE Cows Milk Proteins”
https://www.tandfonline.com/doi/full/10.1080/09540100400003204
You can just read the abstract and not surprising it is 15+ years old and only recently Celiac.com did an article on it…..
people can’t wait another 15 years for the medical community to pick up on this connection and why I am writing this blog post NOW!
2) SIBO can happen in the Majority of Celiac’s
Note: This study is about SIBO happening in Celiac’s already treated with a gluten free diet.
Almost 2/3 of Celiac’s symptoms got better after treating their underlying causes for a Celiac diagnosis such as SIBO in this study.
3) B-Vitamins that become low when one has SIBO
You will find this a common theme…..after treating Celiac disease…..continued symptoms continued until the
underlying cause(s) like SIBO, Cows Milk, Low/NO stomach acid or Medicines keep triggering Villi blunting…
I can only tell you it helped me to treat my underlying cause’s like Low Stomach Acid and my B-Vitamin deficiencies
going undiagnosed as part of Celiac disease diagnosis.
See this new research that verify this fact from 2020 just a year old…from Chicago University
https://medicalxpress.com/news/2020-02-mouse-celiac-disease-treatments.html
Where they note quoting
“Even while maintaining a strict gluten-free diet, 40% of celiac disease patients still show signs of inflammation and villous atrophy,
or damage to the villi, the small, finger-like protrusions in the small intestine that help absorb nutrients. Therefore, treatments that
can reverse or prevent the disease are greatly needed to improve quality of life for people with celiac.”
Tryptophan can do that. So can B1 (Thiamine), B2 (Riboflavin) and B3 (Niacin) if you can believe the latest research on this topic.
Some of it is 15 or 20 years old now….and doctors are not aware of this groundbreaking research.
4) Low/NO Stomach Acid
See this research discovered 30+ years ago entitled “Gastric morphology and function in dermatitis herpetiformis (DH) and in Celiac disease”
https://www.ncbi.nlm.nih.gov/pubmed/3992169
Celiac’s are suffering now and can’t wait another 10 or 15 years before they rediscover this research on their own!
I wrote a Posterboy blog post about this too about how Low/NO Stomach acid could be the trigger for a subsequent
Non Celiac Gluten Sensitivity diagnosis aka NCGS ….but few people seemed to understand it…
Recently PPIs use has shown to trigger a Celiac diagnosis…..and yet nonchalantly this research is minimized….
among other medicines that can also trigger Villi Blunting (Atrophy) with use…
See this Celiac.com thread about it…how PPIs, NSAIDS and SSRIs use were found to be associated with Villi Atrophy
and subsequent Celiac diagnosis.
See also this thread about how some Blood Pressure Medicine might blunt your Villi….
Back to the discussion at hand….how Zonulin can be a biological marker for a Niacin deficiency…
This is important because Niacin is used in Stomach Acid production….
Zonulin as a marker for a (Low) Niacin levels aka Deficiency confirms IMHO a metabolic trigger for Pellagra
going undiagnosed in Celiac disease.
The IJCD noted this association of Pellagra in Celiac’s in 2015…..where they noted the majority or 58 percent approximately
of Celiac’s would be Co-Morbid with their Celiac disease.
It just nobody has followed up on these associations…..because you can’t see Pellagra in people until Skin Rashes develop…..
by then DH has been diagnosed as a symptom of Celiac disease and by then you are too late!
Doctors can’t see how these two diseases are connected but researchers can…….
and fellow sufferers who have suffered at the hands of Doctor’s ignorance of the 4 Ds of Pellagra….
They get a D+ on recognizing Pellagra, Beri and Beri and Pellagra Sine Pellagra in Celiac disease today!
IT is no one’s fault….IT is the process. There are not good B-Vitamin tests to determine the status of B-Vitamin deficiencies
in Celiac’s and other GI patients.
The FIRST good study about this is the link I noted above that confirmed the SEVERITY of the Thiamine deficiency
IE Beri Beri predicted the SEVERITY of UC and Chron’s patients!
Provided here again for easy reference…
See this research entitled "Wernicke Encephalopathy in Crohn's disease and Ulcerative Colitis"
https://www.sciencedirect.com/science/article/pii/S0899900721000447
Why would we not think it would be the same for Celiac disease!
And IF the research is to be believed low Zonulin levels are an indicator of Low Niacin levels aka Pellagra
in it’s most severe presentation of perfuse Skin Lesions….being diagnosed as DH today!
ETA: Found only this month (week) while writing this article/blog post
Very recent research Circa 2021 also confirmed that eating gluten free alone does not heal all Celiac’s making supplementation
with B-Vitamins (IMHO) and Magnesium, in part, an essential treatment for those suffering from inflammation not due to gluten!
See this research entitled “Do gluten-free diets provide a cure-all for celiac disease” and the answer is unequivocally NO…
In a subset of Celiac’s.
https://medicalxpress.com/news/2021-02-gluten-free-diets-cure-all-celiac-disease.html
Quoting their conclusion(s)
A significant number of patients previously thought to be well-treated by a gluten-free diet may in fact require
additional interventions to fully curb their gut inflammation.
Don’t be surprised if takes another 10 or 15+ years of “more study” to confirm these findings!
Each generation much pass on their knowledge to the next….or it soon becomes lost again…
This is my humble attempt to pass on that knowledge.
To quote Isaac Newton
“I do not know what I may appear to the world, but to myself I seem to have been only like a boy playing on the seashore,
and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of
truth lay all undiscovered before me.”
— Isaac Newton
I did this first for myself…..with the hope that it might help others someday.
3 Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort;
4 Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith
we ourselves are comforted of God.
It is my sincerest hope that I was able to throw a few “Starfish” back. But I fear I have not helped enough!
http://www.starrbrite.com/starfish.html
The Starfish Story Original Story by: Loren Eisley
"One day a man was walking along the beach when he noticed a boy picking something up and gently
throwing it into the ocean.
Approaching the boy, he asked, What are you doing?
The youth replied,
Throwing starfish back into the ocean. The surf is up and the tide is going out. If I don’t throw them back, they’ll die.
Son, the man said, don’t you realize there are miles and miles of beach and hundreds of starfish?
You can’t make a difference!
After listening politely, the boy bent down, picked up another starfish, and threw it back into the surf. Then, smiling at the man,
he said I made a difference for that one!"
Part 4 Additional Resources
Is COVID 19 primarily a GI disease first
See this research entitled “Severe COVID19 Is Fueled by Disrupted Gut Barrier Integrity”
https://www.medrxiv.org/content/10.1101/2020.11.13.20231209v1.full
Is “Leaky Gut Syndrome” a sign of Vitamin/Mineral deficiency
See this research entitled “Regulation of the intestinal barrier by nutrients (Nutrition): The role of tight junctions”
https://onlinelibrary.wiley.com/doi/10.1111/asj.13357
And this one entitled
Intestinal permeability and oxidative stress in patients with alcoholic pellagra
https://pubmed.ncbi.nlm.nih.gov/16713031/
See also the is Live Journal article about how Zonulin can be a “Marker for Niacin Issues”….IE is Zonulin a sign of Pellagra
going undiagnosed or Misdiagnosed as Celiac disease today!
https://alobar.livejournal.com/2930798.html#/2930798.html
I can also recommend this blog post on Zinc deficiency by Blue Sky
 

How Low B Vitamins can Trigger a Celiac diagnosis and be Mistaken for a Genetic Disease
To Whomever May Read This,
(Thank you for taking the time to read it and I hope it helps you the way it did me! and if it
does tell others....is all I ask)....because I know there are many more fellow sufferers still looking for answers...
(because many/most B-Vitamin deficiencies up to 80 percent of the time (especially a Thiamine Deficiency)
is going undiagnosed or misdiagnosed in other diseases)....and probably a Riboflavin Deficiency too because they occur together....
Read the blog post and you will see what I mean....
Note: this Posterboy blog post will have 2 portions…. A high level summary and an Appendix/Addendum list of available
resources that support these suppositions…
Depending on whether you have read the other Posterboy blog post(s) will determine how you want to read this one….
If this is your first then read it all…IF you have read other Posterboy blog posts…then just jump to the Appendix where
the references/additional resources are….and all the dirty details...
The Posterboy blog post starts now…entitled "How Low B Vitamins can Trigger a Celiac diagnosis and be Mistaken for a Genetic Disease"
For a while now (10 to 12+ years now)…..I have been studying B-Vitamins to see what role if any they (B-Vitamins) might
have in regulating our Immune System and if they could be the trigger for my GI problems or could have been mistaken
for my Celiac disease diagnosis….
Note: I did not say my Celiac disease….but my diagnosis as a Celiac….see Appendix for other possible triggers.
I had written two previous articles/Posterboy blog posts one about Thiamine (Beri Beri) aka Vitamin B1 and
one about Niacin (Pellagra) aka Vitamin B3.
Provided here for easy reference.....if you want to go back and read them sometime...
Both play a critical role in our immune system and down regulate inflammation pathways in the body…
This Posterboy blog post/article unites the two into an "Elegant Theory" of how and why these occur together in Celiac disease.
I had previously done an unpublished article/blog post on Riboflavin….which I might share in the future (but probably not at this point)
This Posterboy blog post will serve as the argument (thesis) that Riboflavin deficiency is common in Celiac’s going commonly undiagnosed/misdiagnosed….much like the other B-Vitamin deficiencies of Thiamine (B1) and Niacin (B3) in Celiac’s.
I have now found that it is a cascade of all three of these B-Vitamins and maybe 4 (beyond the scope of this blog post Vitamin B6)…..
B1, B2, B3 work synergistically together to control inflammation in the body.
I found first that Pellagra could be common in Celiac’s going undiagnosed/misdiagnosed….
Then I found that Beri Beri might also be the reason for Celiac’s thin Villi….
SO I had to write about it/that too!.....but no ONE Vitamin/Mineral answered all the questions….
So that made me think I could be wrong about the Pellagra question (in part) at least…
IF there is NO SKIN issues IE DH with your Celiac diagnosis then you have NOT YET developed Pellagra….
but more appropriately Pellagra Sine Pellagra…..or Pellagra without skin issues….
And brings me to the point of my current Posterboy blog post.
I believe that most Celiac’s have developed Pellagra Sine Pellagra.
Now granted they developed Beri Beri FIRST….because B-Vitamin deficiencies NEVER happen alone….
It (Celiac disease) is a sequalae (aftermath) of B-Vitamin deficiencies…and possibly some Minerals like Magnesium
and Zinc and Copper etc….(Again beyond the scope of this post)
See this Posterboy blog post to see how nutrients (IE Vitamin and Mineral Deficiencies), Genetics and your Environment
(STRESS) interact…. To produce disease…
So how did I arrive at Pellagra Sine Pellagra instead of Pellagra or Beri Beri (only)….
Because you definitely develop Beri Beri (FIRST)…..why not continue on the Pellagra tack…
There is a couple of distinguishing features between the two most notably the level of SKIN involvement….
Pellagra is a very VISUAL disease…..IF you don’t have DH or other Skin problems then you have not yet developed Clinical Pellagra….
But Pellagra Sine Pellagra a Riboflavin deficiency has all the same symptoms of Pellagra without the pervasive skin issues…
Make no mistake about it….I had already developed Beri Beri first (horrible fatigue) and Peripheral Neuropathy etc….
They typically occur together…..because as noted earlier B-Vitamin deficiencies don’t occur alone…
ONE will affect the others…
And why I landed on B2 (Riboflavin) instead of B3 (Niacin)….
The 2nd clue was the pervasive Iron deficiency issues most Celiac’s develop.
Is Notable that Iron Deficient Anemia aka IDA is very common in Celiac’s…
And people have forgotten how Riboflavin aka Vitamin B2 plays an important role in Iron deficient anemia…
https://pubmed.ncbi.nlm.nih.gov/31318024/
Riboflavin deficiency individuals often have fertility problems as well…
I too had these same problems that got better after Riboflavin supplementation…
Riboflavin again aka Vitamin B2 can cause people to have Hypothyroid problems…..which again was me three….
got better after Riboflavin supplementation…
Reason number 4) Anxiety can be the first sign of a Riboflavin deficiency check that one off too!
Reason number 5) Riboflavin is the trigger for a Homocysteine problem…..commonly diagnosed as MTHFR Gene defect….
https://chrismasterjohnphd.com/blog/2019/02/26/mthfr-just-riboflavin-deficiency/
Check, Check, Check, Check, Check….I had all the signs of a Riboflavin deficiency and the doctor’s missed them ALL!
Not to mention the hallmark angular cheilitis (Leaky Lips) for years…..and the doctor could only recommend for/to me was
to stop leaking my lips sooooooo much!
ALL this symptom’s and more got better after supplementing with Riboflavin….
SO that is why I know Pellagra Sine Pellagra happened to me and is also happening in other Celiac’s going undiagnosed/Misdiagnosed.
The Iron Deficient Anemia…..can be treated (in many if not most cases) with either/by treating your Low Stomach Acid or
by taking Riboflavin and/or Copper.
See this research entitled “Is achlorhydria (No Stomach Acid) an (independent) cause of iron deficiency anemia”
https://pubmed.ncbi.nlm.nih.gov/25994564/
The answer was a resounding yes!
So, I had developed low/NO stomach acid as the trigger for my Celiac/NCGS diagnosis…
AND just what another intrepid research discovered/studied 35+ years ago and was promptly forgot and
never believed….the more things change…the more they stay the same!
See this research entitled “Gastric morphology and function in dermatitis herpetiformis (DH) and in Celiac disease”
https://www.ncbi.nlm.nih.gov/pubmed/3992169
That should be the end of the discussion…..but It won't be....while their patients suffer...they will do more studies about it!
Quoting the whole abstract for emphasis!
Abstract
“Gastric acid secretory capacity was evaluated in 116 patients with dermatitis herpetiformis by means of the pentagastrin test.
Endoscopic gastric mucosal biopsy specimens were obtained from both the body and the antrum in 90 of them.
Forty-eight patients (41%) had a maximal acid output less than 10 mmol/h, and 30 of them (26%) were achlorhydric. T
he frequency of achlorhydria increased with age, and 27 out of 58 patients (47%) more than 50 years old were achlorhydric.
Antrum-sparing chronic atrophic gastritis was present in 92% of the achlorhydric patients, and hypergastrinaemia and
serum parietal cell antibodies were found in most of them. The prevalence of chronic gastritis of the body and of the antrum
increased with age. There was no correlation between atrophic gastritis or achlorhydria and small-intestinal villous atrophy,
the results of the D-xylose test, and blood folate and serum zinc determinations. The transferrin saturation index was lower
in patients with achlorhydria. The frequency of achlorhydria was significantly higher in patients with dermatitis herpetiformis
than in 69 patients with celiac disease.”
Note: 90+ percent of Celiac’s have NO stomach acid (at all)….this is not counting the percent of Celiac’s where just
Low in Stomach acid….mind you
This was not in NCGS but a study of Celiac’s who were already diagnosed as Celiac’s….
But EVEN this is not enough to get some people to believe!!!!
The research is out there…..this is a Classic example of Co-Morbidity….IE a Sequelae of one condition triggering the other!
The aftermath of B-Vitamin and Mineral deficiencies of Zinc, Magnesium, B1 (Thiamine), B2 (Riboflavin), B3 (Niacin) and
possibly Copper is being diagnosed as NCGS and/or as Celiac disease diagnosis IMHO!
It is my hope by sharing this old research rediscovered that at least ONE other person will believe me (YOU) and be helped!
Use a Celiac disease diagnosis as the way back. . . . not the end of the road for your health but the beginning of your way back to health!
As the I have the Lord being my help!
As I am fond of saying “To Educate is to truly free!” Where there is a free exchange of knowledge there is health and
peace for one’s soul and body!
So, what can I do NOW about this know that I know B-Vitamins might help my Celiac diagnosis?
There is “No Formula” but this is the best advice I can offer you.
Take a B-Complex AND a Benfotiamine (Fat Soluble B-1) or other Fat Soluble B-1s like AlliThiamine or
Lipothiamine (harder to find) AND a Magnesium Citrate (with meals) or Magnesium Glycinate (anytime)
2x to 3x a day (with meals) for 3 to 6 months.
(IF you are not taking an acid reducer like a PPI or H2 Blocker (better of the two kind with less long term side effects) )
you will begin to burp continuously even up to 2 hours after you have finished your meal…..
and between meals with the smallest snack… producing the biggest BURPS you have had in years, and years.
Don’t stop for at least 6 months….don’t stop taking them when you begin burping (again without bloating/gas distension)
BUT continue for 6 months till BURPING without these other symptom’s and a regular movement will become your new normal.
You are now again digesting proteins in your diet triggering a food allergy.
What I didn’t know at the time was that Pellagra is a “Capstone” diagnosis and not the “Cornerstone” disease.
Pellagra is definitely happening in Celiac’s because Tryptophan has been shown the ability to be a therapeutic for Celiac’s.
See this research about it… https://www.eurekalert.org/pub_releases/2020-10/aaft-tri101920.php
Here is another article about the same research indicating Tryptophan as Therapeutic treatment for Celiac’s…
https://www.news-medical.net/news/20201023/Intestinal-microbiota-offers-new-prospects-for-treating-celiac-disease.aspx
Confirming that when you develop “Leaky Gut Syndrome(s)” you have developed Pellagra.
But Pellagra does not happen alone and is not the trigger….it is the combination of multiple B-Vitamin deficiencies beginning
with Low Thiamine (B1), then Low B2 (Riboflavin) and finally Low Niacin (B3) aka Niacinamide presenting as DH in Celiac’s…
I did not develop Pellagra but Sine Pellagra instead!
Note: as to not overpower the reader (you) with too much information see addendum/appendix for more
reference’s resource where you can read to your Heart’s content (as much) or as little as you need to help you understand
these “Lost Connections” explaining
how the Chicken came before the Egg (Diagnosis). First you develop Low B-Vitamin deficiencies (IE Thiamine deficiency
or undiagnosed Beri Beri) THEN your Villi Thin and THEN you develop Pellagra Sine Pellagra a Riboflavin deficiency
leading (in time) finally to a/your Celiac diagnosis!
Also Note: SIBO and Cows Milk Protein IE Casein (not Lactose as is commonly believed) might also be a problem for you.
See the Appendix for more details.
2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.
I hope this is helpful but it is not medical advice.
Posterboy by the Grace of God,
ADDENDUM/Appendix
Resources
Thiamine the Overlooked Vitamin That Improves Autoimmune Disease And Autonomic Dysfunction
https://awaken.com/2021/02/the-overlooked-vitamin-that-improves-autoimmune-disease-and-autonomic-dysfunction/
The issues/symptoms of a Thiamine deficiency hide in other diseases….
It is only suspected (tested) for in diseases with high clinical suspicion such as Alcoholics and Anorexic’s etc….
Also here is a nice overview of how to recognize a Thiamine deficiency…
https://healthprep.com/articles/fitness-nutrition/guide-symptoms-thiamine-deficiency/#:~:text=Weight loss may occur in a thiamine deficiency,individuals called AMP-activated protein kinase (AMPK) becomes impaired.
Here is the best thread on a Thiamine deficiency and its many presentations/faces/symptoms on Celiac.com
for more resources on Beri Beri in GI diseases like Celiac disease and IBS etc.
Recently Celiac.com wrote an article linking AnitGAD antibodies to Celiac disease.
So that set me out to see if there was a link between Gluten Ataxia and AntiGAD antibodies….
And it turns out AntiGAD antibodies are diagnostic confirmation of a Thiamine deficiency in Celiac’s manifesting themselves as Gluten Ataxia…
See this research that explains the connection… entilted “Wernicke's encephalopathy: an excitotoxicity hypothesis”
https://pubmed.ncbi.nlm.nih.gov/9346467/
This confirms exactly what is happening in other GI diseases like UC and Chrons.
See this research entitled "Wernicke Encephalopathy in Crohn's disease and Ulcerative Colitis"
https://www.sciencedirect.com/science/article/pii/S0899900721000447
AS if often the case in WE the treatment is too little too late….let's not let the same thing apply/happen to Celiac disease patients too!
IF the research on UC and Chrons’ is to be believed Low Thiamine level’s can be a predictor of disease severity and recovery.
NOW a similar study needs to be done to confirm my many years of research proving once and for all….
A Thiamine deficiency is the trigger for Thin Villi!
Note: The Hormones Matter website is the best Thiamine resource on the web….and EON Health is a close second.
Zonulin a Marker for Niacin deficiency
Links/Resources https://alobar.livejournal.com/2930798.html#%2F2930798.html
Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine: Trp enhanced tight junction protein ZO-1…
https://www.researchgate.net/publication/312962348_Dietary_Tryptophan_Enhanced_the_Expression_of_Tight_Junction_Protein_ZO-1_in_Intestine_Trp_enhanced_tight_junction_protein_ZO-1
Dietary l-tryptophan alleviated LPS-induced intestinal barrier injury by regulating tight junctions in a Caco-2 cell monolayer model
https://pubmed.ncbi.nlm.nih.gov/30977499/
Intestinal permeability IE Leaky Gut and oxidative stress in patients with alcoholic pellagra (reversed with Niacinamide)
https://pubmed.ncbi.nlm.nih.gov/16713031/
Which is what the latest research confirms Tryptophan can be used in Celiac’s to heal Villi
https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx
Does Going Gluten Free Provide Relief or All Celiacs? The answer is NO!
https://medicalxpress.com/news/2021-02-gluten-free-diets-cure-all-celiac-disease.html
And why I recommended B-Vitamins as an adjunct treatment for Co-Morbidities that happen in Celiac’s.
This a complimentary approach. See this Posterboy blog post that discusses the B-Vitamins that might help treat a Celiac diagnosis
About 40 pct of Celiacs are NOT helped when they go gluten free.
This is about what else someone can do that is still triggering Villi blunting when eating gluten fee is not enough to heal your Villi???
Three or four of the most common triggers (IMO) for continued GI inflammation (Issues) in IMO are
Milk (Cows’ Milk Protein) aka CMP in the literature.
See this great Celiac.com article about how Milk in peoples diet can also trigger Villi Blunting…
A reaction to Cows Milk Protein (Casein) can happen in up to 40 percent of Celiac’s…
See this nice study on the issue of Caseins’ also triggering an Immune response in Celiac’s
Entitled “IgA anti-gliadin antibody immunoreactivity to food proteins IE Cows Milk Proteins”
https://www.tandfonline.com/doi/full/10.1080/09540100400003204
You can just read the abstract and not surprising it is 15+ years old and only recently Celiac.com did an article on it…..
people can’t wait another 15 years for the medical community to pick up on this connection and why I am writing this blog post NOW!
2) SIBO can happen in the Majority of Celiac’s
Note: This study is about SIBO happening in Celiac’s already treated with a gluten free diet.
Almost 2/3 of Celiac’s symptoms got better after treating their underlying causes for a Celiac diagnosis such as SIBO in this study.
3) B-Vitamins that become low when one has SIBO
You will find this a common theme…..after treating Celiac disease…..continued symptoms continued until the
underlying cause(s) like SIBO, Cows Milk, Low/NO stomach acid or Medicines keep triggering Villi blunting…
I can only tell you it helped me to treat my underlying cause’s like Low Stomach Acid and my B-Vitamin deficiencies
going undiagnosed as part of Celiac disease diagnosis.
See this new research that verify this fact from 2020 just a year old…from Chicago University
https://medicalxpress.com/news/2020-02-mouse-celiac-disease-treatments.html
Where they note quoting
“Even while maintaining a strict gluten-free diet, 40% of celiac disease patients still show signs of inflammation and villous atrophy,
or damage to the villi, the small, finger-like protrusions in the small intestine that help absorb nutrients. Therefore, treatments that
can reverse or prevent the disease are greatly needed to improve quality of life for people with celiac.”
Tryptophan can do that. So can B1 (Thiamine), B2 (Riboflavin) and B3 (Niacin) if you can believe the latest research on this topic.
Some of it is 15 or 20 years old now….and doctors are not aware of this groundbreaking research.
4) Low/NO Stomach Acid
See this research discovered 30+ years ago entitled “Gastric morphology and function in dermatitis herpetiformis (DH) and in Celiac disease”
https://www.ncbi.nlm.nih.gov/pubmed/3992169
Celiac’s are suffering now and can’t wait another 10 or 15 years before they rediscover this research on their own!
I wrote a Posterboy blog post about this too about how Low/NO Stomach acid could be the trigger for a subsequent
Non Celiac Gluten Sensitivity diagnosis aka NCGS ….but few people seemed to understand it…
Recently PPIs use has shown to trigger a Celiac diagnosis…..and yet nonchalantly this research is minimized….
among other medicines that can also trigger Villi Blunting (Atrophy) with use…
See this Celiac.com thread about it…how PPIs, NSAIDS and SSRIs use were found to be associated with Villi Atrophy
and subsequent Celiac diagnosis.
See also this thread about how some Blood Pressure Medicine might blunt your Villi….
Back to the discussion at hand….how Zonulin can be a biological marker for a Niacin deficiency…
This is important because Niacin is used in Stomach Acid production….
Zonulin as a marker for a (Low) Niacin levels aka Deficiency confirms IMHO a metabolic trigger for Pellagra
going undiagnosed in Celiac disease.
The IJCD noted this association of Pellagra in Celiac’s in 2015…..where they noted the majority or 58 percent approximately
of Celiac’s would be Co-Morbid with their Celiac disease.
It just nobody has followed up on these associations…..because you can’t see Pellagra in people until Skin Rashes develop…..
by then DH has been diagnosed as a symptom of Celiac disease and by then you are too late!
Doctors can’t see how these two diseases are connected but researchers can…….
and fellow sufferers who have suffered at the hands of Doctor’s ignorance of the 4 Ds of Pellagra….
They get a D+ on recognizing Pellagra, Beri and Beri and Pellagra Sine Pellagra in Celiac disease today!
IT is no one’s fault….IT is the process. There are not good B-Vitamin tests to determine the status of B-Vitamin deficiencies
in Celiac’s and other GI patients.
The FIRST good study about this is the link I noted above that confirmed the SEVERITY of the Thiamine deficiency
IE Beri Beri predicted the SEVERITY of UC and Chron’s patients!
Provided here again for easy reference…
See this research entitled "Wernicke Encephalopathy in Crohn's disease and Ulcerative Colitis"
https://www.sciencedirect.com/science/article/pii/S0899900721000447
Why would we not think it would be the same for Celiac disease!
And IF the research is to be believed low Zonulin levels are an indicator of Low Niacin levels aka Pellagra
in it’s most severe presentation of perfuse Skin Lesions….being diagnosed as DH today!
ETA: Found only this month (week) while writing this article/blog post
Very recent research Circa 2021 also confirmed that eating gluten free alone does not heal all Celiac’s making supplementation
with B-Vitamins (IMHO) and Magnesium, in part, an essential treatment for those suffering from inflammation not due to gluten!
See this research entitled “Do gluten-free diets provide a cure-all for celiac disease” and the answer is unequivocally NO…
In a subset of Celiac’s.
https://medicalxpress.com/news/2021-02-gluten-free-diets-cure-all-celiac-disease.html
Quoting their conclusion(s)
A significant number of patients previously thought to be well-treated by a gluten-free diet may in fact require
additional interventions to fully curb their gut inflammation.
Don’t be surprised if takes another 10 or 15+ years of “more study” to confirm these findings!
Each generation much pass on their knowledge to the next….or it soon becomes lost again…
This is my humble attempt to pass on that knowledge.
To quote Isaac Newton
“I do not know what I may appear to the world, but to myself I seem to have been only like a boy playing on the seashore,
and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of
truth lay all undiscovered before me.”
— Isaac Newton
I did this first for myself…..with the hope that it might help others someday.
3 Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort;
4 Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith
we ourselves are comforted of God.
It is my sincerest hope that I was able to throw a few “Starfish” back. But I fear I have not helped enough!
http://www.starrbrite.com/starfish.html
The Starfish Story Original Story by: Loren Eisley
"One day a man was walking along the beach when he noticed a boy picking something up and gently
throwing it into the ocean.
Approaching the boy, he asked, What are you doing?
The youth replied,
Throwing starfish back into the ocean. The surf is up and the tide is going out. If I don’t throw them back, they’ll die.
Son, the man said, don’t you realize there are miles and miles of beach and hundreds of starfish?
You can’t make a difference!
After listening politely, the boy bent down, picked up another starfish, and threw it back into the surf. Then, smiling at the man,
he said I made a difference for that one!"
Part 4 Additional Resources
Is COVID 19 primarily a GI disease first
See this research entitled “Severe COVID19 Is Fueled by Disrupted Gut Barrier Integrity”
https://www.medrxiv.org/content/10.1101/2020.11.13.20231209v1.full
Is “Leaky Gut Syndrome” a sign of Vitamin/Mineral deficiency
See this research entitled “Regulation of the intestinal barrier by nutrients (Nutrition): The role of tight junctions”
https://onlinelibrary.wiley.com/doi/10.1111/asj.13357
And this one entitled
Intestinal permeability and oxidative stress in patients with alcoholic pellagra
https://pubmed.ncbi.nlm.nih.gov/16713031/
See also the is Live Journal article about how Zonulin can be a “Marker for Niacin Issues”….IE is Zonulin a sign of Pellagra
going undiagnosed or Misdiagnosed as Celiac disease today!
https://alobar.livejournal.com/2930798.html#/2930798.html
I can also recommend this blog post on Zinc deficiency by Blue Sky
 

Genetics Nutrition and Stress the Threeway Model of How Gluten Triggers an Immune Reaction in Severely Malnourished
IE Vitamin Deficient Individuals consuming a High Calorie Diet
This blog post is WTL again....I tried breaking it into to two Posterboy Blog posts but decided to go ahead....
And post it instead as one due to other things IRL that are taking up most of my time these days.....
So thanks in advance to every one who actually completes it! I truly believe it will help everyone who reads it and UNDERSTANDS!
This Posterboy blog post is for everyone  who got lost in the “Forest of Data” and never found their way out!
As I am fond of saying “To Educate is to truly free!” Where there is a free exchange of knowledge there is health
and peace for one’s soul and body!
The journey of a thousand miles begins with the first step….that step back to health for me was my seemingly rare
and not well understood Celiac disease diagnosis…
I then began my journey….to  learn at least what the doctor’s knew about this  diagnosis….and exceed it if I could…
But I got lost in the forest of data….for years…going around in circles…or so it seemed at the time…
See my first attempt to hack/machete my way out of this sad forest (of illness) I was in…
/celiac-disease/a-differential-diagnosis-how-pellagra-can-be-confused-with-celiac-disease-r3989/
But I soon learned to spot clues as I read more and more studies….trends, patterns…in the data begin to emerge…
one tree (study) at a time…I was able to blaze a trail back out  of the forest…
I can honestly say I am out of the forest now….and by blazing this  trail….I hope I have left enough markers
(IE posterboy blog posts/articles etc.) to help the next person out of this forest of symptom’s…..
I had over focused on every shiny thing I found (individual Vitamin Deficiency one tree at a time)….
I begin to identify each Vitamin (tree of health) in this vast forest…
I  had settled on the 3 alarm fire of Pellagra….I didn’t know how wrong and right I was at the same time…
It would take years to figure this out (as I walked around in circles)….it is what others had concluded before…
The IJCD had concluded the same  thing a couple years earlier…
http://pubs.sciepub.com/ijcd/3/1/6/
They confirmed for me…it was possible…
They noted: on how Pellagra occurred in Celiac disease…
Pellagra and celiac disease
“The two diseases can be connected in two aspects. 58% of pellagra patients were shown to have malabsorption
and many had intestinal pathology on biopsies [36, 37]. Alternatively, Pellagra was described in celiac disease [38].
The skin manifestations in pellagra might have some additional etiologies, since multiple nutrient deficiencies
are at the origin of the cutaneous manifestations in celiac disease. The following nutritional deficiencies inducing skin rashes,
were describe in celiac disease: Zinc, Iron, Vitamin A, E, B12, niacin, folate, selenium and essential fatty acids [39, 40].”
 
So Eureka! I had found what was being misdiagnosed as Celiac disease instead…
58% was good….I was more than halfway there….being right and  wrong all at the same time!
Then I found that there was another disease that explained these connections even better!
/celiac-disease/how-low-thiamine-can-thin-villi-old-research-rediscovered-and-its-clinical-significance-in-celiac-disease-r5100/
Now I had found out what was really causing my problems! I thought…and once again I was right
and wrong all at the same time….
While my aim was dead on….it was nutrients (or lack thereof more correctly)  causing my health problems…
I had become too myopic only seeing individual trees and the not the forest ….for what  it was a healthy place to
live and thrive and fruit for meat and leaves for medicine…
It was all the trees (at least 3 in particular)….together forming a Web of Life…
To pivot from the metaphor to hard science (in real life aka IRL) ….how do know this analogy is true….or truer than not!
To see if this is true we have to dig deep in the forest of data….and see what it tells us…
See this research entitled “Pellagra in the USA: unusual manifestations of a rare entity”
https://casereports.bmj.com/content/12/9/e230972
On the surface….it is just as we would suspect…Pellagra is rare in the USA…right only in Alcoholic’s right….
But we if we dig a  little deeper….we learn something from this good research…
Quoting from their abstract…
“They/She had adrenal function testing which revealed adrenal insufficiency. Vitamin testing revealed normal B12
and folate levels but undetectable levels of thiamine, riboflavin and niacin. Her symptoms and signs resolved entirely
with appropriate vitamin supplementation. Niacin (vitamin B3) is essential for multiple metabolic pathways,
and severe deficiency may cause clinical syndrome of pellagra, which is most commonly associated with diarrhoea, delirium and dermatitis.”
Notice the bolded Vitamin Deficiencie(S)….not one deficiency but many deficiencies culminating
the a “Capstone” disease diagnosis….
Now why did this researcher not  say the  patient had Beri Beri (B1 deficiency), or Pellagra Sine Pellagra
(B2 deficiency) instead…they/she had ALL these deficiencies….
Because B-Vitamins don’t occur alone or uncomplicated….so I was right to say I had gone on to develop
(mostly) Pellagra ….except I didn’t  have Skin (dermatitis) problems like DH etc….so I had only developed
Pellagra Sine Pellagra instead…(so far)…
But I had already gone on to develop Thiamine deficiency aka Beri Beri and the doctor’s had already missed it….
So why should  I be surprised they missed me having a Riboflavin deficiency too!
What most people don’t know (even doctor’s) don’t realize today….and I have recently found out that Pellagra
has been incorporated into Celiac disease today…..
Celiac disease is a three alarm metabolic (deficiency syndrome/disease) ramped up by each B-Vitamin you become low in
…..in time…. It is a Cascade….like falling domino’s….one falling triggers the others too fall as well…
Let’s see if there is research to backup this claim….
See this research published before 1950 (15+ years) before DH was associated with Celiac disease….
https://www.jidonline.org/article/S0022-202X(15)50482-X/pdf
They show that DH was successfully being treated with Nictonic Acid aka Niacin more than 15 years before 
DH was described in the Skin of Celiac patients…
Quoting from their summary
“In a series of 12 patients with dermatitis herpetiformis of various degrees of severity, the oral administration of niacin
in doses of 50 to 200 mgm. four times daily relieved the pruritus (Itching) and improved the cutaneous manifestations.”
 
Yet today we exclusively “see” through50+ years of error(s)…having forgotten that DH can be treated with Niacin….
thus confirming a Pellagra diagnosis in a Celiac patient…
It is the third phase (3 alarm stage) of the  Vitamin Deficiencies you have now developed….
Don’t be surprised if the doctor’s don’t see your Vitamin Deficiency even then…
Because in classic genetics….the environment and nutrition is discounted as limited factors….in disease…
But other researchers are now rejecting this myopic view realizing Environment (Viruses etc.) and Deficiencies IE
(Vitamins and Minerals) ALSO play a part in the pathogenesis of disease  in an equal 50/50 mix….
See this 2 year old research that summarizes such an hypothesis entitled…
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease
Here is the link…to this seminal and groundbreaking research…
https://science.sciencemag.org/content/356/6333/44 /tab-e-letters
Where Doctor Leslie M. Klevay , Prof. Emeritus, Department of Internal Medicine University of North Dakota School
of Medicine and Health Sciences says quoting
“In the original classification scheme, Celiac disease would have been considered a toxic deficiency
(3) similar to Wernicke’s encephalopathy in which excessive ingestion of ethanol induces thiamine deficiency.
Now some celiac disease can be considered a three-way cooperation among an infection,
a toxin and a deficiency. Other three- and four-way cooperations have been identified.”
Here is longer and probably better description how Virus's (Environment) or IE Epigenetics could/can
trigger an Genetic disease like Celiac disease...
https://www.gutmicrobiotaforhealth.com/virus-may-lead-celiac-disease-disruption-intestinal-immune-homeostasis/
The research is a couple years old.....also the Epstein Barr Virus has also been associated with Celiac disease.
Dr. Londsdale says we need a “new Model” for Medicine…
https://www.hormonesmatter.com/new-model-medicine/
I say we need a better one that acknowledges the environment and deficiencies as important or as important as genetics….
Other researchers have noticed the same thing….your environment and deficiencies are not being taken into account for Celiac’s.
See this recent research that says the same thing entitled “Genetic risk factors for disease can be affected by environment”
https://www.upi.com/Health_News/2017/08/16/Genetic-risk-factors-for-disease-can-be-affected-by-environment/4251502820421/
Not only are genetic risk factors for Celiac disease being affected by your environment….
they are effected by your deficiencies like Thiamine, Riboflavin and Niacin….
We know this because they have been studied (these three B-Vitamins) for toxic overload in Sepsis….
where the Auto-immune system goes haywire and results in death…
See this research in Rats
https://pubmed.ncbi.nlm.nih.gov/30903555/
It will take a few years for this study to be confirmed in humans….while more studies are performed
more people will be dying of  Vitamin Deficiencies….
Despite 8+ years ago Riboflavin has been proven to treat (MADD) disorder resulting in acute Renal Failure….
https://www.jstage.jst.go.jp/article/internalmedicine/50/21/50_21_2663/_pdf/-char/en
People still think it is 70/30 genetics or even 80/20  genetics…
Recent research for Celiac disease proves it is no more than 50/50 percent Genetics/Environment
 IE (Vitamins deficiency etc. AKA malnutrition)
It is my hope that clinical practice will quickly catchup with the newest/latest research proving
DNA/Genetics usually has less than 50pct of the risk factors for Celiac disease and accept many
Vitamin deficiencies are prevalent as co-morbidities and need to be addressed before a Valid Celiac
diagnosis can be accepted/confirmed…. See this studied that confirms this in Celiac’s
https://www.genengnews.com/news/dna-has-relatively-little-say-in-disease-risk-usually/
Where they say quoting
“It is becoming increasingly clear,” explained Wishart, “that the risks for getting most diseases arise
from your metabolism, your environment, your lifestyle, or your exposure to various kinds of nutrients,
chemicals, bacteria, or viruses.”
And though Celiac disease is a disease consider to have a higher genetic factor it is now believed to be
no more than 50% of the risk factor …..as once commonly believed…
quoting again
“There are diseases, however, for which the genetic contribution is about 40–50%. These diseases include
Crohn’s disease, Celiac disease, and macular degeneration.”
But I don’t believe they (doctor’s/Clinicians) will……memory has  a “longtail” of approximately 18 years from new
research reaching clinical practice on average…
Appropriate supplementation is consider a key part of “Aftercare” for Celiac’s ….it needs to be part of appropriate
disease diagnosis (IMHO)….so you don’t continue to suffer from the avoidable and treatable diseases
that often in as many as 80pct of patients are found out Post-Mortem….as is the case in Wernicke Encephalopathy (WE)…
etc.…and it should be NOTED 80% of WE is not diagnosed in Alcoholics…..
it is happening in Celiac’s today and/or passed off as other GI diseases like Chrons, IBS, UC
etc. and psychiatric or neurogenerative diseases today….
https://www.hormonesmatter.com/beriberi-the-great-imitator/
see this current research on Thiamine Deficiency and Benfotiamine Therapy in Brain Diseases
https://biomedgrid.com/fulltext/volume3/thiamine-deficiency-and-benfotiamine-therapy-in-brain-diseases.000621.php
You will fell half-dead if you continue to have these deficiencies if they doctor don’t also treat you for these
co-morbidities despite being on a gluten free diet!
I know I did….Ignorance kills!....but It maims us first!
I hope this is helpful but it is not medical advice….
Posterboy by the Grace of God
At this point I am only making one Posterboy blog post....see following/below for more technical studies......
Showing how and why this is true and how the doctor's missed it!
Note to Self::::::))))) Put this a Part 1 of the Blog post and then link the Smoking Gun research on Tryptophan…
ADDENDUM
IF this analysis is true and a good working Theory and not just a good hypothesis we would find research that
shows Tryptophan is important in the pathogenesis of Celiac disease and new research in 2020 confirmed this analysis.
Celiac.com ran a summary of the research but I will link a good synopsis for others to read for themselves showing
how Celiac’s have impaired metabolism of Tryptophan.
/celiac-disease/tryptophan-in-turkey-meat-can-speed-gut-healing-in-celiac-disease-r5338/
This good synopsis of this working theory shows how Tryptophan speeds gut healing in Celiac IMHO
proving Pellagra is happening in Celiac’s.
I would recommend reading it ALL when you get a chance.
https://www.gutmicrobiotaforhealth.com/gut-microbes-in-celiac-disease-show-impaired-metabolism-of-dietary-tryptophan-according-to-researchers-at-mcmaster-university/
And like most “All” good medical research….they always conclude “more research/study” is needed….
Well people can’t want another 10 or 15 years until this research is again confirmed (and again)
See this research entitled “Kynurenine pathway metabolites in humans: disease and healthy States”
https://pubmed.ncbi.nlm.nih.gov/22084578/
This connection was established at least 10+ years ago….and now we can say for SURE IMHO
that this metabolic breakdown is triggering inflammation in Celiac’s leading, in time, to a Leaky Gut!
Again, I want to say (make note) that the International Journal of Celiac disease aka IJCD first noticed
this connection 5 years ago…will it take another 10 or 15 years before it is “accepted” medical research???
I hope not: but I AM honestly not encouraged!!!
This was meant to be a 2 part blog post….so It doesn’t get too long and too technical…but I have
decided to publish it all at once now that I am working through some other health issues at the moment!
If this is true….there should be studies about these facts….and there is….
I have argued IT is ONE immune system with multiple presentations of the difference Phases of Vitamin Deficiencies….
We see how this works in the LUPUS Inflammation Model
I wrote a Posterboy blog post about these connections….
https://www.celiac.com/blogs/entry/2709-the-lupus-inflammation-model-for-sickness-beginning-with-b-vitamin-deficiencies-in-celiacs-and-other-inflammation-triggered-diseases…/
Here is the recent research it is based on…describing how IL-2 and IL-6 combine to help control the immune system….
We see this Alcoholic’s too…in how Niacin can help Leaky guts…
See this Celiac.com thread about this topic…
https://www.celiac.com/forums/topic/126496-intestional-permability-could-a-vitamin-deficiency-cause-it/?tab=comments#comment-1009633
And that is exactly what we want to fix in Celiac’s right….well B-Vitamins do that!
And we see B-Vitamins are low in other chronic inflammation GI diseases like IBS, Chron’s and UC…because there is ONE Immune System!
See this research entitled “Blood Concentrations and Renal Clearance of Water-Soluble Vitamins in Outpatients With Ulcerative Colitis”
https://pubmed.ncbi.nlm.nih.gov/30906550/
Quoting
“The blood concentrations of vitamins B2, C, niacin and folate were markedly lower in the patients with UC
than those in the control group, and the renal clearance of vitamins B1, B6, B12 and folate was notably higher
in the UC cohort. It was concluded that vitamins B2, C, niacin and folate were at significantly lower concentrations
in patients with UC following adjustment for coexisting factors. The lower levels of niacin may be partially due to
impaired reabsorption. Chronic inflammation, common in patients with(my words and/or chrons, IBS etc. and Celiac disease),
with UC may contribute to the lower levels of other vitamins by rendering amino acid and carbohydrate metabolism
into a hypermetabolic state. As the role of vitamins in metabolic activity is constant and pervasive, nutritional management
including the application of water-soluble vitamins appears important for patients suffering from UC.”
It is me again….why wouldn’t we think this would be the same in Celiac’s…..and why I believe the new research
that shows Tryptophan helps heal Celiac Villi is key to  understanding/proving Celiac is Pellagra in disguise in the 21st Century!
It is time testing is done to confirm these same B-Vitamin deficiencies in Celiac’s is all I am saying so the Co-morbidities
can be treated…leaving a true diagnosis…
If not the same Vitamin Deficiencies could be confused for Celiac and you will never be sure if you ever received the proper diagnosis….
I have had to figure this out on my own….this is written so you won’t have t o suffer like I did for year’s going
undiagnosed despite a Celiac diagnosis….
Two front wars are rarely winnable.
Disguise is a great trick of the enemy. For if you get the wrong diagnosis then the symptom’s never getting better and the battle/war rages on.
But What If you have the wrong disease? Would you get better?
This is dedicated to those still suffering who are willing to ask why? am I still suffering GI symptom’s on a Gluten free diet?
Since (auto-immune) or disease in general rarely occur alone it only makes sense to tackle the easiest one’s first.
There are two camps/type of people. (It is true in many things of life).
Supplementing or not to supplement is the 64K dollar question.
The one’s who believes in supplementing readily attack the front (symptom’s) on/from whatever artillery (vitamins and minerals)
they can find to shore up their defenses.
The other camp prefers to hunker/bunker down and wait for reinforcement/symptom’s to get better and the battle/siege to pass.
But in war there is an old saying. “A city besieged is a city taken”.
I know there is a lot of confusion out there. … I have been YOU!
I am just trying to help those who are still suffering (losing the war). For a battle the war was lost. And many battles’ are lost from confusion….
Knowledge is power …..know you have to power to move forward!
It is been said Doctor’s miss Celiac’s in 90% of their patients…
https://www.celiac.com/articles/24919/1/Are-Doctors-Missing-90-of-Celiac-Disease-Cases/Page1.html
It is equally true about how often Vitamin Deficiency are missed in Celiac’s…
“How could this be? One reason is that even classic Celiac disease symptom, such as abdominal pain,
bloating, gas, diarrhea, anemia and weight losscan mimic other conditions. Less classic symptoms such as fatigue,
low vitamin C, D and calcium levels can be misleading.”
Lupus is known as the great imitator disease. And Celiac or is it Pellagra could be called the same
in 87% of cases if you are lucky.
And so is Beri Beri…
https://www.hormonesmatter.com/beriberi-the-great-imitator/
Imitation is the sincerest form of flattery —
Unless it is medicine then it is the unkindest cut. . .
How do we know this is true…we can predict that  Pellagra would develop in Sorgen’s disease aka SLE
or LUPUS and it does…where they ask how confident are you of your diagnosis…explaining DH in detail (IF)
you did not know it also described Pellagra instead (Rough Skin)…
https://www.dermatologyadvisor.com/home/decision-support-in-medicine/dermatology/pellagra/
Dermatology doctor’s get it because a Niacin deficiency is 90% classically described as a skin disorder first and foremost….
But Beri Beri and Pellagra GI’s problems are a forme fustre of WE’s….FIRST a Thiamine deficiency and finally a Niacin deficiency
when it present’s as DH today!
See this research that explains how the first signs of these Vitamin Deficiencies are GI related…
.entitled“Gastrointestinal Beriberi: A Forme Fruste of Wernicke's Encephalopathy?”
https://pubmed.ncbi.nlm.nih.gov/29982183/
I can only hope what I have shared here has lifted the tide of knowledge a little and your boat/that
has been lifted enough for you to freely sail again.
Learn from my mistakes! No body is so dumb who won’t learn from other people’s mistakes!
A valid I dare say standard “process” of modern/good medicine is the differential diagnosis.
If it is not the doctor has not done justice for you or YOU for yourself . …
A “differential diagnosis” makes more sense.
They have not done YOU justice.  Isn’t that what we all want – to know just what we need to do to get
better that is justice/peace and good medicine.
We are our own best advocate!
I share that other’s may know to look for these Vitamin Deficiencies if you too received a Celiac diagnosis
and the Doctor’s don’t “See” it in your face….like those of nearly 70 years ago who were treated for DH by Niacin(amide)……
15+ years before DH was ever linked to Celiac disease
 Remember **** This is not medical advice and should not be considered such. Results may vary.
Always consult your doctor before making any changes to your regimen.
2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.
As I am fond of saying “To Educate is to truly free!” Where there is a free exchange of knowledge there
is health and peace for one’s soul and body!
Let’s all make peace for to educate is to empower to change.
Change is not easy . . especially if you have a bunker mentality I grant . . . but possible with education
for with education comes understanding!
2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies,
and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them
which are in any trouble (starfish/sufferer), by the comfort wherewith we ourselvesare comforted of God.”
Posterboy by the Grace of God,
EPILOGUE
We know this is a good working theory because both B1 (Thiamine) and B3 (Niacin) are used in the production of stomach acid.
Quoting from the Celiac.com article on How Low Thiamine Can Thin Villi
How Low Thiamine Can Thin Villi: Old Research Rediscovered and its Clinical Significance in Celiac Disease - Celiac.com
“Via the Parasympathetic Nervous System (PNS) the neurotransmitter "acetylcholine" regulates our organ functions
throughout the body, and could be why both undiagnosed celiac disease and Beri Beri affect so many organs in the body.
Without enough thiamine our body can’t synthesize enough acetylcholine to regulate it’s organs, which may cause the body
to go into high alert mode and trigger a runaway auto-immune reaction like celiac disease. Another study shows a connection
with the microvilli that line organs and how they can trigger auto-immune reactions throughout the body.”
B3 aka Niacin via Histamine is used to trigger stomach acid production and why an H2 Blocker is used to treat stomach
acid issues….and can be used for other immune mediated conditions like allergies etc…
Low Thiamine (B1) triggers the Auto-Immune Cascade….leading to low B2 (Riboflavin) and finally resulting in Low B3 (Niacin)….
who’s production in the body is regulated by Tryptophan via the Knyneurine Pathway and
why Tryptophan recently was shown to help heal Villi in Celiac’s.
And why just over 7 years ago PPIs were shown to be able to trigger a Celiac diagnosis.
Do Proton Pump Inhibitors Increase Risk of Celiac Disease? - Celiac.com
See my previous Posterboy blog post about why this so.
Is there a Type I and Type II Celiac Disease IF so what is your Type: What the Diabetic Model can tell us
about Celiac Disease Subtypes? - Celiac.com
Niacin (B3) and Thiamine both help control the Biofeedback loop in the body and why being low in either one
will trigger an auto-immune cascade!
And Note: it is not just humans who need Thiamine to live/survive ALL animals need it even Bacteria and Fungus.
See this latest research from 2020 entitled "Born to be wild: Fungal highways let bacteria travel in exchange for thiamine"
that shows/explains how Bacteria and Fungi or Fungus use Thiamine as "Currency" along "Life's" highway....
https://www.sciencedaily.com/releases/2020/09/200924114128.htm
Dr. Lonsdale called Thiamine the "Spark of Life".....I have called it the "Currency of Life"....because your health will be poor without IT!
So we know this is true! Even at the microscopic level!
You will feel half-dead if you continue to have these deficiencies if they doctor don’t also treat you for these
co-morbidities despite being on a gluten free diet!
I know I did….Ignorance kills!....but It maims us first!
Lord willing it has been helpful and will it will help someone before the medical community
catches up with the latest research on the topic.
As always 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.
Posterboy by the Grace of God

A Case for Thiamine Supplementation in Celiac’s IF only for a Season in Time
I have been doing Posterboy blog posts every so often now for a while now to share my experience with supplementation.
I have settled on the fact that many of the existing GI issues can triggered by existing nutritional deficiencies.
((I think most people must think I still take Niacinamide or Thiamine or a B-complex.....I do not now take any of these things. 
I only took them for a Season in Time and the reason for the name of this Posterboy blog post.
For many taking an Enzymic B-Complex with Benfotiamine (preferably with Magnesium Glycinate or Magnesium Citrate with meals)
for  3 to 6 months when taken with meals will be enough, for some 6 months or longer might be needed.....
you  decide the Season and the times that is best for you!))
See this research entitled “Nutritional inadequacies of the gluten free diet in both recently diagnosed and long term
patients with celiac disease”  Open Original Shared Link
As I often note….. research is 5 or 10 years old (for whatever topic it is)…in this case that Thiamine is not only Low
at diagnosis of a Celiac diagnosis…continuing to eat a gluten free diet without supplementation will make you even LOWER in Thiamine.
This is not a case of the “Chicken or the Egg”….. a Thiamine deficiency comes FIRST….then you develop GI problems IMHO.
This leads to an impaired Vagus Nerve response…. Open Original Shared Link
I once thought this was a Niacin deficiency (and in part it still can be) but it begins with a Thiamine Deficiency first
(beyond the scope of this Posterboy blog post)…..when one develops the skin condition of DH in/with their Celiac diagnosis….
the Celiac has gone onto to develop a Niacin deficiency.
I never developed full blown Pellagra (beyond limited skin involvement) I did not develop symptom’s beyond
Pellagra Sine Pellagra aka as a Riboflavin deficiency as noted by horrid Angular Cheiliitis (Leaky Lips)….
After extensive PMing back and forth with EnnisTx (I don’t think I ever told him) I realized….I had gotten the wrong diagnosis….
so from then I adjusted/iterated the model.
I changed my opinions/mind about my conclusions…..and realized I had been wrong….
So that sent me back to the drawing board(s) so to speak…..if it wasn’t Pellagra what was it….
And I will skim over this portion because it is only an intermediate step in the process as noted above I had developed
not Pellagra but Pellagra Sine Pellagra a Riboflavin deficiency.
See this research entitled “Kynurenine pathway metabolites in humans: disease and healthy States”
Here is the abstract to keep it on the lighter side…. Open Original Shared Link
Once the Kynurenine Pathway breaks down…essentially your immune system goes haywire…
Here is the more technical answer via their conclusion on the Kynurenine Pathway and disease states…
“Conclusion
The kynurenine pathway is an effective mechanism in modulating the immune response and in inducing immune tolerance.
This is achieved by accelerating the degradation of tryptophan and the generation of kynurenines. The metabolites of the pathway,
with their different inherent properties, can also synergize or antagonize the effects of one another. By measuring the levels of tryptophan,
kynurenines and the K/T ratio under various pathological conditions, the degree of immune activation and the relationship between
the kynurenine pathway and disease states may be gleaned. However, much research is still needed to fully understand the complex
interaction between tryptophan, IDO and kynurenines among themselves and within the CNS and in the periphery. With the seemingly
prevalent involvement of the kynurenine pathway in a wide range of different diseases and disorders, the knowledge gained from research
focusing on the kynurenine pathway may be translated into designing novel and more effective treatment strategies.”
I did not set out to learn this….but only set out for the truth of the matter.
But from there I was able to back track and find out the trigger for this cascade…
It was not B3 or B2 (not really) but B1….(Or lack thereof) that was the real trigger…
I have been counting down B-Vitamins all this time….you might say I have been counting down to One!
The combination of these B-Vitamins (B1, B2, B3) had been shown to down regulate inflammation in the body.
See where this was recently studied in the mouse model for health entitled
“Vitamin B combination (of B1, B2, B3) reduces fluconazole toxicity in Wistar rats”
Open Original Shared Link
And while they each work to down regulate inflammation…..together they are dynamite!
But what was the Spark??? That creates the BOOM!
Thiamine is the Spark for Energy!
According to Lonsdale it (Thiamine) is the “Spark of Life”…. Open Original Shared Link
Stress requires energy and we absolutely can NOT make energy without Thiamine.
The Thiamine deficiency came First…..It is not a “Chicken AND the Egg” scenario.
One interesting new study that illustrates this point and I will try and wrap up this Posterboy blog post at least for a Season of Time.
Let’s go back to the B1, B2, B3 issue of picking which one is the Spark for the Autoimmune BOOM triggered by inflammation.....
Sepsis is a condition in the body that is triggered by unchecked infection often….and what down regulates inflammation in the body???
Answer B-Vitamins at least in part…..we know B1, B2, and B3 work synergistically to down regulate inflammation in the body thereby
controlling first inflammation and thus Sepsis.
How can we know it is B1 instead of B3…because new research bears this fact out!
See this Sciencedirect article about Thiamine and Sepsis and how unchecked inflammation can be a sign of a Thiamine deficiency
not the other way around … Open Original Shared Link
quoting
Effect of Sepsis on Intestinal Thiamine Uptake Thiamine deficiency is prevalent in patients with sepsis.15–17 This appears to be
mediated in part via an effect of sepsis on intestinal thiamine uptake37 given recently reported observations of a significant
inhibition in intestinal thiamine uptake in rat model of sepsis where the degree of inhibition was shown to correlate with the severity of sepsis.
The degree of the Thiamine Deficiency correlated with the degree of the Sepsis!
Again, the Thiamine deficiency came First…..It is not a “Chicken AND the Egg” scenario.
To quote Ecclesiastes 3 (read it all if you get chance) it is so well known the first few verses can be quoted (or commonly known).
And it is often quoted  at major life events such as death and at marriages or when one gets sick…..this too can pass!
But if you want energy during these emotional times you can’t pass by Thiamine!
Ecclesiastes 3:1 “To everything there is a season, and a time to every purpose under the heaven:”
It is time for a “Season of Thiamine” to fight off the stress and inflammation your GI tract is now experiencing because your
body is low in Thiamine……
before medically diagnosable Beri Beri develops from unchecked inflammation in the body!
There will be time of Joy! Of Celebration that you found out what was causing your “Chronic” Fatigue
that the doctors couldn’t diagnose!  Because they didn’t know the cause of the unchecked inflammation
Open Original Shared Link
I had similar things happen to me….before Sepsis develops someone in a Celiac Crisis will develop Refeeding Syndrome…..
presenting itself as “Electrolyte Abnormalities”
See my Posterboy blog post how I was a Posterboy for a Thiamine deficiency post and the doctor’s were misdiagnosing it!
 
If this is the right diagnosis you would expect patterns to emerge in the research and when we look we see we/they do!
2 out of 3 Celiac’s who do not respond to a gluten free diet get (feel) better when they are treated for SIBO or unchecked
inflammation from an overgrowth of bacteria!
 
And a Thiamine Deficiency is known to be common in a SIBO diagnosis.
It Turns out the Bacteria need Thiamine for their Spark of Life too! Draining your in the  process leading to your Fatigue!
And new research is emerging that Toxic Shock (this is no longer an hypothesis) but a working Theory that “Thiamine (vitamin B1)
(can be used) in septic shock: a targeted therapy” which IMO is being triggered by gluten in Celiac’s when you First get low in
Thiamine presenting as a Celiac Crisis or being Misdianosed as Refeeding Syndrome or SIBO in IMO.
Open Original Shared Link
I must stop before this blog post gets too long again……
I truly hope it helps someone else! It is time for a Season of health!
I share that it might help the next person…..so they won’t have to suffer without the doctor’s help the way I did!
I hope this is helpful but it is not medical advise.
2 Corinthians 1:3, 4
3 Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort;
4 Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort
wherewith we ourselves are comforted of God.
2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included.
Posterboy by the grace of God,
ADDENDUM
IF you have a spare hour of your time this youtube link about how a Thiamine Deficiency can lead to Vagus Nerve
disorders is worth your time! Entitled “Is Thiamine Deficiency Destroying Your Digestive Health? Why B1 Is ESSENTIAL For Gut Function”
Or if you prefer to reading to video this is a nice article that shows the Thiamine Deficiency in a SIBO Patient connection…
and remember in 2 out of 3 Celiac’s who do not get better eating a gluten free diet feel better after treating their SIBO
Or is it more appropriately treating their Thiamine Deficiency???  A Season of Thiamine (or a B-complex) can tell you
if it was the "Chicken or the Egg".  What have you got to loose but Time! It is time for a Season of Health!
Open Original Shared Link