knitty kitty
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Celiac.com - Celiac Disease & Gluten-Free Diet Support Since 1995
Blog Comments posted by knitty kitty
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Thiamine Mononitrate is not well absorbed and not utilized well by the body.
Thiamine Hydrochloride and Benfotiamine are forms the body can utilized much easier. Benfotiamine has been shown to promote intestinal healing.
Thiamine needs magnesium to make some essential enzymes. A magnesium citrate or magnesium glycinate supplement should be taken with Thiamine.
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More research articles on Malnutrition in Celiac Disease
Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398893/
Nutritional Status and Metabolism in Celiac Disease: Narrative Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419423/
The Gluten-Free Diet for Celiac Disease: Critical Insights to Better Understand Clinical Outcomes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537989/
Multidimensional Disadvantages of a Gluten-Free Diet in Celiac Disease: A Narrative Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920475/
Micronutrients Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681258/
Knowledge of Medical Students and Medical Professionals Regarding Nutritional Deficiencies in Patients with Celiac Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224609/
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More information....
Damage to the small intestine (villus atrophy) results in malabsorption of essential vitamins and minerals. B vitamins cannot be made by the human body. We must get sufficient B vitamins from our diet every day because B vitamins cannot be stored. Unfortunately, the gluten free diet can be low in essential nutrients, especially if gluten containing products (which are required by U.S. law to be enriched and fortified with vitamins and minerals) are replaced with gluten free facsimile foods (not required to be enriched and fortified at all).
Taking B Complex supplements boosts the availability and absorption of these essential vitamins.
Discuss the benefits of supplementing with your Nutritionist or dietician, as well as your doctor. Unfortunately, many doctors are not as well educated about the importance of vitamins as we would wish. As a microbiologist, I understood how important these essential vitamins are to cellular function and health.
Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet
https://pubmed.ncbi.nlm.nih.gov/19154566/
...Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet
https://pubmed.ncbi.nlm.nih.gov/34445038/
And...Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/33912967/
... Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey
https://pubmed.ncbi.nlm.nih.gov/33848753/
Thiamine Vitamin B 1 has been shown to alleviate depression and promote intestinal healing.
...Thiamine and benfotiamine: Focus on their therapeutic potential
https://pubmed.ncbi.nlm.nih.gov/38034619/
...Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/
And...Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial
https://pubmed.ncbi.nlm.nih.gov/26984349/
And...Thiamine nutritional status and depressive symptoms are inversely associated among older Chinese adults
https://pubmed.ncbi.nlm.nih.gov/23173173/
Riboflavin Vitamin B 2 helps....
Dietary riboflavin intake in relation to psychological disorders in Iranian adults: an observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060244/
Pyridoxine Vitamin B 6 helps...
Vitamin B6: A new approach to lowering anxiety, and depression?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577631/
And Folate Vitamin B 9....
Folate and Its Significance in Depressive Disorders and Suicidality: A Comprehensive Narrative Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490031/
And Vitamin B 12 Cobalamine....
Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression
https://pubmed.ncbi.nlm.nih.gov/33251075/
And Niacin Vitamin B 3....
Dietary niacin intake in relation to depression among adults: a population-based study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506255/
....Diagnostic value of niacin skin blunting response in adolescent patients with depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634130/
....Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode
https://pubmed.ncbi.nlm.nih.gov/23380314/
I found taking Tryptophan, a form of Niacin Vitamin B 3, more effective than any SSRI. Tryptophan is used by our bodies to make more Serotonin.
Serotonin is normally made in the intestines, but inflammation due to Celiac disease can reduce its production. With less serotonin being made, depression results. SSRIs prevent serotonin from being reabsorbed, so more serotonin is available.
However, Tryptophan is used to easily make more Serotonin. With more serotonin available, there's no need for a SSRI.
Do NOT take Tryptophan while taking an SSRI, which can result in Serotonin Syndrome (too much serotonin that can result in physical and mental symptoms).
Demystifying serotonin syndrome (or serotonin toxicity)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184959/
My doctors had prescribed a plethora of pharmaceuticals which resulted in me developing Serotonin Syndrome. Easily corrected by stopping the pharmaceuticals. I just take Tryptophan since without problems.
And Vitamin D helps, too...
Is Vitamin D Important in Anxiety or Depression? What Is the Truth?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468237/
All of these vitamins help heal the digestive system and lower inflammation.
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Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398893/
Hiding in Plain Sight: Modern Thiamine Deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
Thiamine and benfotiamine: Focus on their therapeutic potential
https://pubmed.ncbi.nlm.nih.gov/38034619/
Thiamine and benfotiamine: Focus on their therapeutic potential
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682628/
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Yes, I'm reading Dr. Lonsdale and Dr. Marrs' book "Thiamine Deficiency Disease, Disautonomia, and High Calorie Malnutrition".
I got so ill so quickly from a gluten challenge, I opted for genetic testing.
Hippocrates said "first do no harm" which is counterintuitive to doing a gluten challenge. He also said "let food be your medicine."
High dose Thiamine really helped me. It's safe, nontoxic and you would be amazed at how much it helps.
More articles by Dr. Lonsdale and Dr. Marrs can be found on Dr. Marrs' website https://www.hormonesmatter.com
And their published peer reviewed articles are available on PubMed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
https://www.ncbi.nlm.nih.gov/pmc/?term=Lonsdale+Derrick
Hope this helps!
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Hope you are feeling better.
Gastroparesis or slowed transit time can be a symptom of Thiamine insufficiency, as can constipation.
Thiamine helps keep SIBO in check.
Tryptophan and Pyridoxine B6 are needed to make serotonin.
Some people need methylcobalamine instead of regular B12. Having the MTHFR genetic variation occurs frequently with Celiac Disease.
Riboflavin B2, Thiamine, Folate or methylfolate, and Vitamin C and copper are also needed to produce red blood cells in anemia.
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I'm doing great now. Thanks for asking.
I have taken a B 100 Complex. There's different brands and prices, so pick one that fits you. Make sure the vitamins are free from gluten.
I have taken the eight B vitamins individually. It's just really what fits in with you.
I personally don't like multivitamins because they have minerals which can hamper vitamin absorption.
I take the B vitamins before or at the beginning of a meal and minerals at the end of the meal.
And, of course, I take additional thiamine in the form Benfotiamine which helps heal the digestive tract. I also take Allithiamine or Thiamax, forms of Thiamine that help the brain with neurological symptoms.
Hope this helps!
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It's not just B12 and Vitamin D deficiencies. Doctors know those are the only two tests for vitamin levels that are fairly reliable. The thing is we can have vitamin deficiencies before the blood levels change.
Doctors don't mention or pay attention to the other B vitamins that are needed for all eight B vitamins to work properly together. This is why people are misdiagnosed and suffer for so long.
B Complex vitamins plus additional high dose Thiamine and minerals like magnesium, iron, potassium and trace elements.
I'm sorry you've had such a rough journey, too. But you've got friends and a support system here now. Let's move forward to healing.
Keep us posted on your results! Best wishes.
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I bought Dr. Sarah coffee!
Dr. Sarah's Autoimmune Protocol Diet changed my life!
Let's donate to help save her website!
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Did you know thiamine helps zinc get absorbed?
"Role of vitamin-zinc interactions on in vitro zinc uptake by human erythrocytes"
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Anonyous Cda,
If you want to increase energy for your mind, try Lipothiamine. It's a form of thiamine that will cross the blood brain barrier. It's available on Amazon.com.
6 hours ago, AnonyousCda said:I overdose on B6, B12, take a little of Biotin. Increase energy for the body and mind.
But also add in Amino Acid deficiency testing is needed for Celiacs.
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Posterboy,
Lol, I had low T, too, and I'm a girl! And the angular chelitis, chapped lips, and a waxy, flaky rash around my mouth, nose, chin area!
The doctor wanted to do an implant for the testosterone levels, but I didn't get it. He couldn't explain why the testosterone was low in the first place, so I knew it would be just a bandaid without getting to the root of the problem. That doctor was just one of the many doctors who completely missed my vitamin deficiencies.
I agree, doctors and people in general overlook vitamin deficiency symptoms. Ignorance about vitamin deficiencies nearly killed me, too.
Thiamine, Riboflavin, Niacin and Vitamin C should be taken every day. Especially with the CoVid virus around because these help your immune system so much!
Thanks for sharing!
Knitty Kitty
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Keight,
Without enough thiamine to turn carbohydrates into energy, the body uses a shortcut that uses less thiamine and turns carbohydrates into fat. This may be the explanation for the increase in obesity and NAFLD.
High fructose corn syrup has to be processed through the liver, just like alcohol, and depletes thiamine stores and causes NAFLD.
Niacin is also helpful in reducing liver enzymes and triglycerides.
The eight essential B vitamins are water soluble and need to be replenished every day. They all work together, and, with Celiac Disease, it's possible to have deficiencies in more than one of the B vitamins. Because they are water soluble, any extra your body doesn't use is excreted in urine.
Please discuss with your doctor the benefits of supplementing thiamine and niacin. I'm not a doctor. I'm a microbiologist who has done a lot of research.
Recently, scientists have discovered that during thiamine deficiency, the thiamine transporters that allow thiamine to enter cells quit working. The chromosomes that controls the thiamine transporters are on the same gene as Celiac Disease and Diabetes and other autoimmune diseases we Celiacs get. In order to turn the transporters back on, high doses of thiamine are needed. Sometimes results aren't seen until 500mg or 1000mg are taken for several weeks, then the dose can be lowered to 300 - 500 mg a day.
I have Type Two Diabetes which requires extra thiamine. I take at least 300mg a day, 500mg if I'm eating more carbs. I control my diabetes with diet, and by supplementing with niacin and thiamine. I don't have NAFLD anymore. My doctor was pleasantly surprised.
Hope this helps! Thanks for being interested!
Knitty Kitty
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I have experienced thiamine deficiency. The fatigue and heavy, tingling limbs, and the mood changes, anxiety, depression, and insomnia, the elevated liver enzymes, adrenal fatigue, and the intolerance of starchy vegetables or carbohydrates are all symptoms of thiamine deficiency.
I lived through thiamine deficiency. It began subtly, but symptoms above increased. It gets worse.
Do either of you two "kates" have any of these thiamine deficiency symptoms?
Open Original Shared Link
11 Signs and Symptoms of Thiamine (Vitamin B1) Deficiency
And blood tests aren't always accurate. Please read this to understand how thiamine can still be low despite "normal" blood tests
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Thiamine Deficiency Testing: Understanding the Labs
Please get checked for thiamine deficiency with the proper tests. The body can keep"normal" levels of thiamine in the blood in order to feed the brain, but muscle cells and other cells are starving for thiamine. You have to measure the by products produced when thiamine is utilized.
The World Health Organization has a field test for thiamine deficiency. Can you rise from a squatting position to the standing position?
I squatted down in the grocery store to get an item off the bottom shelf. I could not for the life of me stand back up.
Please discuss properly testing for thiamine deficiency with your doctor.
Hope this helps!
Knitty Kitty
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Namaste
We both want to help.
My experience involves severe vitamin deficiencies. I live in a poor, rural, uneducated area. The doctors I saw were intent on writing prescriptions to make money, not in finding out what was happening to me. They did not seem capable of thinking outside the box.
I had been given the gift of a university education and with the knowledge and abilities earned there, I researched until I found answers for myself. I want to share that gift of knowledge with others. Knowledge is power.
I encourage posters to discuss vitamin deficiencies with their doctors and nutritionists before starting supplementation.
We both want to help.
Namaste
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Cycling Lady,
Oh, Cycling Lady,
You say your Celiac Disease was diagnosed because you jumped on the bandwagon with your friends who were all having age fifty colonoscopies. And, surprisingly (because you had no overt symptoms), you were diagnosed with Celiac. You're an accidental Celiac!
Oh, yes, you did have a bit of a stretch after the dental work where you weren't well with hives and chronic gastritis. Can you imagine living in that state of misery for years? For the majority of your life?
And how would you have felt if your doctor had said "Go home, eat a gluten free diet and it will resolve by itself" ?
I found this study.....
Efficacy of gluten-free diet alone on recovery from iron deficiency anemia in adult celiac patients
Open Original Shared Link
"CONCLUSIONS:
A screening for celiac disease should be carried out in adult patients with iron deficiency anemia. Recovery from anemia occurs between 6 and 12 months on a gluten-free diet alone as a consequence of normalization of histological alterations of the Open Original Shared Link."
I don't know how others may feel, but if my doctor told me to go home, eat a gluten free diet, and come back in six months to a year to check if, maybe, my anemia had resolved by diet alone, I think I'd have run screaming to find a new doctor.
Your experience, Cycling Lady, with Celiac Disease is far removed from mine, from Posterboy's, and from a fair amount of posters on this forum.
There are many of us who have struggled for years with health problems related to a disintegration of our bodies by the ravages and consequences of celiac disease. (I'm remembering Bartful.) There are people who have struggled with their health over the course of their entire lives. There's gastrointestinal symptoms, ataxia, pain in joints and muscles, neurological disorders, depression, infertility, and the list goes on and on. These people are hurt, confused, and discouraged. They are looking for answers, a relief to their suffering.
These people want to feel better as quickly as possible, especially if they've been suffering for years.
And you glibly gloatingly boast of being all healed and in remission because you stuck to the gluten free diet.
You took supplements for your anemia, iron and B12. Others can have different deficiencies. Would you have them all wait six months to a year and maybe recover on the gluten free diet?
There are some deficiencies that can cause permanent damage if not corrected immediately.
There's a lot to learn about nutrition and a healthy gluten free diet.
The gluten free diet can still lead to nutritional deficiencies.
Open Original Shared Link
Open Original Shared Link
There's no way you can eat (and absorb) enough to correct a vitamin deficiency in some cases.
I see no harm in supplementing. Some need specific vitamins or minerals. For some just a multi vitamin/mineral complex will suffice. An ounce of prevention is better than a pound of cure.
Vitamin products assembled in the USA are at least tested for quality and purity.
Perhaps you should reflect on your life and, by comparison with others, be thankful you didn't have to suffer any worse or any longer than you did. Be grateful your celiac disease was caught so early and so quickly resolved.
I study for light in order to share the light with others. As does Posterboy.
Do you?
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Hi, Ennis!
I hope your ambulance works out for you. There's a technical school nearby that rebuilt a man's truck when it was stolen and trashed. I wonder if a technical school near you would be interested in helping to refit your truck.
Are you supplementing calcium? Calcium and magnesium need a balance. I remember you don't do dairy, and I wondered if you were getting enough calcium from your diet.
I noticed your diet has lots of high sulfur foods (eggs, bacon, sausage, nuts and seeds, bones broth, garlic, onions, and nutritional yeast).
Awol mentioned her sensitivity to perfumes. This happened to me, too. Oh, the migraines were so bad! Perfumes contain LOTS of Sulfites. I have a hypersensitivity to sulfur, sulfites, sulfates. If it's airborne, I get migraines and my head stuffs up immediately, and asthma attacks. If it's in medicine, my DH flares, I get very sick to my stomach, and, oh, horrible stuff happens. One of these articles below says that taking a sublingual B12 at onset of symptoms helps. I haven't tried it yet, but I'm hopeful.
I found improvement by removing foods high in sulfur from my diet. And I supplemented with molybdenum, calcium, magnesium, B12, and B6. The molybdenum really helps!
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And managing sulfite sensitivity.....
Open Original Shared Link
And what a high sulfur environment does to our gut bacteria....(really surprising!).....
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And molybdenum...
Open Original Shared Link
I hope this helps!
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Ennis,
I would recommend taking a low dose of thiamine (or benfotiamine - see below). I take 100 mg of thiamine with my meals. Taking thiamine at night can lead to insomnia. And I would recommend taking the vitamin D in divided doses with meals as well.
Big round hamburger buns sound great. I don't do hot dogs because of the microbial transglutaminase (food manufacturers call it meat glue) added to it which has the same inflammatory effect as tissue transglutaminase (measured in Celiac tests).
Hmmm, kitchen renovations....dry wall and a door to block off kitchen and a special sink drain set up.... I'm curious if that's doable.
Yes, I'm disillusioned with the medical profession. My yucky doctors just kept writing prescriptions and did not bother to figure out WHY my health problems were snowballing.
Scarring in your esophagus? Sounds yucky. Wonder if the scarring could have affected your sphincter muscles going into and out of the stomach. I hope not!
Nerve damage or ataxia? Yikes! A form of thiamine called benfotiamene helps with nerve conductivity.
Quickly found a study on it. I'll see what else I can find.
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And found this article, although it's selling something, it has some helpful information.
Open Original Shared Link
I think I'll try benfotiamine myself. My life as a guinea pig. Heavy sigh. Oh, well. Let's keep pushing forward. "Sempre avanti" (always forward) is my motto.
I'd still like to try those buns. I've been craving Sloppy Joe's sandwiches and they're just not the same without a bun. Lol.
Keep your chin up!
Knitty Kitty
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Hey, Ennis!
I'm sorry to hear you're still having problems with so many things. I wanted to encourage you. Talking with the Mighty is a good way to go. He listens.
Have you thought about a mail order business? Those hot dog buns sound delicious, as do so many of your chocolatey hemp desserts and other creations! I, for one, would love to sample your wares! I don't know what would be involved with a mail order gluten free bakery, but I know your creations would be better than the sawdust-tasting mass produced gluten free junk I've tried and well worth the shipping cost.
I've been worried about your vomiting and bezoars. I've been doing research and didn't seem to get anywhere until recently. Remember I'm not a doctor. So here's some articles I found....
Open Original Shared Link
This article says that in people with gastroparesis, high levels of Vitamin D (above 50, better at 100 ng/mls) help stomach emptying.
Gastroparesis is where foods just sit in the stomach and don't empty out properly. Instead the food just sits there and forms bezoars and causes vomiting.
You know I'm a big fan of Vitamin D and having one's level above the usual 30 ng/ml doctors accept. But not content with Vitamin D as a cure all, I kept researching and I kept coming across articles that connected Thiamine (B1) to pancreas health and that diabetics had a greater need for thiamine for digestive enzymes, insulin and glycagon production.
"But Ennis takes his vitamins," I told myself.
And then I found this article
Open Original Shared Link
I was very pleased with this article because it covers so much information I had unearthed in those NIH studies in one place.
It says that thiamine can be affected by other vitamins when they're taken together. (See the section "Step Three - Supplementation"). B2 riboflavin can affect thiamin hydrochloride so it doesn't work. Plant Lectins which are in nuts and seeds can affect thiamine absorption. And Tannins which are in coffee, chocolate (oh, those cocoa nibs) and nuts, can deplete thiamine. (See the section "Step One - Food - Avoid Antinutrients"). Even medications such as proton pump inhibitors, antidepressants and antibiotics (oh, that tooth) can affect thiamine. (See the section "Step Two - Lifestyle - Mind Your Medications").
Knowing you take a multivitamin, that seeds, nuts and chocolate are a big part of your diet, and have taken PPI's, I'm wondering if you're having a problem with thiamine absorption.
I recently found these articles on niacin and folate deficiency affecting the pancreas, too.
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Open Original Shared Link
Maybe you might consider changing your multivitamin and taking thiamine separately.
I'm type II diabetic and I can tell the difference by my blood sugar readings when I don't take enough thiamine. I thought I might be overdoing thiamine last week and my blood sugar went through the roof, so I'm back to supplementing. Oh, and Bilberry will help lower your glucose levels if you take a big dose before carby meals. I take two capsules before eating rice or starches like peas or sweet potatoes.
I do worry about you and wish the best for you. Keep talking to the Mighty.
Do message me if you can send me some of those hot dog buns and something chocolatey! And, as always, I hope this helps.
Knitty Kitty
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I heard you should put broken teeth in whole milk and then in the fridge.
I cracked off a corner of my back molar recently. It doesn't show, but I can empathize. A celiac relative cracked off both of her front teeth.
My Asperger sense of humor says it's time to go shopping for a grill!
Maybe adding a calcium supplement to balance out the magnesium will help. The body leeches calcium out of teeth and bones when it needs more.
Egads, that makes my stomach hurt! Where's your fund me page?
Kitty
Nutritional deficiencies on Gluten free diet References
in Thiamine Thiamine Thiamine
A blog by knitty kitty in General
Posted
Doctors are required to take twenty hours of nutritional education while in medical schools for seven years. Mostly vitamin deficiency diseases are thought to be in the past or in starving countries. So doctors do not recognize vitamin deficiency disease symptoms in the early stages. Celiac Disease causes vitamin deficiencies because the lining of the small intestine is damaged and unable to absorb nutrients. We're starving for nutrients, those vitamins our bodies cannot make, and minerals, too. We may be consuming sufficient calories, but without a sufficient amount of those vitamins, our bodies cannot process the carbohydrates, proteins and fats from our diet and turn them into energy and building blocks for cell repair and for our bodies' health. Instead, our bodies can store those extra calories as fat to burn for energy, or start burning muscle. This is High Calorie Malnutrition. A diet high in carbohydrates requires an additional .5 mg (minimum) of Thiamine B1 to process those carbohydrates. Benfotiamine, a form of Thiamine, has been shown to promote healing in the intestines.
Vitamins are needed to decrease Inflammation and regulate the immune system. Vitamins are needed for cell repair and replacement, so our villi can grow back and absorb nutrients properly for us.
Gluten containing foods are required to be enriched with vitamins and minerals lost during processing. Gluten Free facsimile foods are Not required to be enriched with vitamins and minerals. The Gluten Free diet can be low in the B vitamins. Talk to your doctor and nutritionist about supplementing with vitamins and minerals while healing.