knitty kitty
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Celiac.com - Celiac Disease & Gluten-Free Diet Support Since 1995
Posts posted by knitty kitty
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Sorry you are having such problems.
Gluten exposure, illness and vaccinations are situations in which there is a higher demand for Thiamine Vitamin B1.
We need more Thiamine when we have an immune response, whether it is caused by a cold or an inoculation to promote an immune response as with vaccines, or upon exposure to gluten and our autoimmune response to gluten.
Thiamine stores can be depleted within three days to three weeks. Subclinical Thiamine deficiency can exist for years. A twenty percent increase in dietary thiamine causes an eighty percent increase in brain function, so symptoms may mysteriously wax and wane. With illness, vaccinations, and gluten exposure, the demand for Thiamine increases, and symptoms flair.
Thiamine has antibacterial properties. Thiamine has analgesic effects, especially when taken with Pyridoxine B 6 and Cobalamine B12. Thiamine has been shown to reduce inflammation in joints.
The Gluten Free diet can be low in Thiamine. Gluten free processed foods are not enriched with vitamins like gluten containing products. Eating a diet high in these carbohydrates can also increase the demand for Thiamine. This is High Calorie Malnutrition.
Supplementing with Thiamine, the rest of the B vitamins, and magnesium is beneficial in correcting nutritional deficiencies as occurs in Celiac Disease.
References:
Thiamine and benfotiamine: Focus on their therapeutic potential
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682628/
Long-Term Treatment by Vitamin B1and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102562/
Thiamine deficiency disorders: a clinical perspective
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/
Hiding in Plain Sight: Modern Thiamine Deficiency
Chandler Marrs and Derrick Lonsdale
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial
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There's a connection between increased liver enzymes and Thiamine deficiency. Thiamine deficiency is a result of malabsorption due to Celiac Disease and increased demand during illness.
Thiamine deficiency can cause Ataxia. Thiamine deficiency can cause lesions on the brain. Thiamine deficiency can cause neuropathy. Thiamine deficiency causes migraines.
Thiamine needs the other seven B vitamins to function properly. You should add a B Complex and Vitamin D.
How much and what kind of Thiamine are you taking?
References:
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988776/
Thiamine deficiency-related brain dysfunction in chronic liver failure
https://pubmed.ncbi.nlm.nih.gov/19067139/
B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial
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When the effects wear off, have you tried taking MORE thiamine?
Have you tried Allithiamine (Tetrahydrofurfuryl Disulfide TTFD) or Thiamax? Are you taking a magnesium supplement, too?
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Fat soluble vitamins are Vitamins A, D, E, and K. There's little risk of toxicity unless one takes supplementing to excessive levels for a long period of time.
https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/#h17
https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#h36
https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/#h14
https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/#h14
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I'm thankful I can help.
An Erythrocyte Transketolase test is a better test for Thiamine deficiency than a blood test. The Erythrocyte Transketolase test needs to be taken before starting vitamin supplementation. Otherwise, the vitamins you take will invalidate the results.
I take Ecological Formulas Allithiamine (Tetrahydrofurfuryl Disulfide TTFD). I take Life Extension Benfotiamine and B Complex. I like these brands because they don't use rice flour fillers and they are gluten free. These are available online.
Thiamine needs magnesium to make enzymes, so be sure to take a magnesium glycinate or magnesium citrate supplement. Magnesium Oxide is not a good choice as it is not absorbed well and pulls water into the digestive system, causing diarrhea or relieving constipation.
Vitamin D needs to be between 75- 100 nmol/L in order to work as it's supposed to. Vitamin D is frequently low in Celiac Disease.
Try the Autoimmune Protocol Diet (AIP diet), a Paleo diet that can help inflammation and promote intestinal healing. Choosing low histamine foods helps further. Remember to consume healthy fats that contain Omega Threes (olive oil, flaxseed oil, algal oil, fish oil, sunflower seed oil) because our brains are mostly fats.
Choose low carbohydrate foods. The more carbohydrates you eat, the more Thiamine is required. Excess carbohydrates feed SIBO bacteria. Thiamine helps keep them in check. Thiamine also helps stop the release of histamine from overly sensitive mast cells.
Malabsorption due to Celiac Disease can also affect trace minerals like molybdenum, iron, selenium, zinc, copper and iodine. Calcium should be checked as osteoporosis is common in Celiac Disease, especially if we avoid dairy.
A discussion with a Nutritionist can be helpful.
References:
Thiamine deficiency disorders: a clinical perspective
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/
Hiding in Plain Sight: Modern Thiamine Deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial
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Welcome to the forum, @lasthope2024,
Blood tests are not reliable measures of vitamin deficiencies.
Antibiotics are known to cause Thiamine Vitamin B1 deficiency.
Gastrointestinal Beriberi is caused by Thiamine deficiency.
"At age 14 I started having constant, chronic abdominal pain and acid reflux (also constipation and reduced appetite, fatigue, moodiness,etc."
All your symptoms here are the same symptoms as Gastrointestinal Beriberi caused by Thiamine deficiency.
"My mind is not the same, my sleep is not the same, my body has never been the same, I don't think the same way."
Thiamine deficiency can produce alterations in brain function, called Wernicke's Encephalopathy.
Thiamine has antibacterial properties. Thiamine has analgesic properties.
The Gluten free diet, even if followed strictly, can be nutritionally deficient in essential vitamins and minerals. There are EIGHT Essential B vitamins, Vitamin C and four fat soluble vitamins. They all work together interdependently. B12 cannot function properly without sufficient Folate B 9, Pyridoxine B 6, and Thiamine B1.
"Supplementation with functional medicine vitamins (B12, D, C, GABA, etc.) had no effect."
Doctors are not given sufficient training in nutrition. They forget to correct the malabsorption caused by Celiac Disease. They don't recognize the subtle symptoms of Thiamine deficiency outside of alcoholism which presents differently. Eventually, Thiamine deficiency symptoms, with or without alcohol, overlap and can result in Wernicke's Encephalopathy, 80% of cases are diagnosed postmortem.
The World Health Organization recommends taking Thiamine and looking for improvement because blood tests for vitamin deficiencies are so unreliable.
Talk to a nutritionist. Take a B Complex supplement with all eight essential vitamins and additional high dose Thiamine in the form Benfotiamine (shown to promote intestinal healing) and Allithiamine (Tetrahydrofurfuryl Disulfide for brain function improvement).
Niacin B3 deficiency can cause GERD and reflux problems. Another form of Niacin, Tryptophan, is necessary to make melatonin which regulates sleep cycles.
Riboflavin B 2 makes essential life sustaining enzymes with Thiamine.
Pyridoxine B6, Cobalamine B12, and Thiamine B1 together have analgesic properties.
Read my blog for excerpts of my journey through vitamin deficiencies.
Hope this helps!
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Some people with Celiac can develop sensitivity to dairy, not just lactose intolerance, but a reaction to Casein, a protein in dairy that resembles gluten. Cradle cap is frequently a manifestation of eczema brought on by this reaction to Casein. In a reaction, repeated exposure to Casein may be tolerated to a point, but then the body's immune system overreacts, which may explain your baby's worsening of symptoms.
Definitely, get him to a pediatrician.
Also consider a Thiamine deficiency disorder. Pregnancy can deplete a mother's stores of vitamins (especially after multiple births), and that deficiency can cause vitamin deficiencies in the infant. Thiamine deficiency with gastrointestinal symptoms is called Gastrointestinal Beriberi. Sudden Infant Death Syndrome (SIDS) has been linked to Thiamine deficiency.
I'm posting an article that studied women and children in a poor third world country, but Thiamine deficiency can and does occur in developed countries, especially those consuming a diet high in carbohydrates and fats. Processed gluten free foods are often high in carbohydrates and fats but few vitamins. Processed gluten free foods are not required to be enriched or fortified with vitamins like gluten based products.
Keep us posted on your progress!
References:
Thiamine deficiency in pregnancy and lactation: implications and present perspectives
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158844/
Hiding in Plain Sight: Modern Thiamine Deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
Thiamine deficiency disorders: a clinical perspective
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/
Pediatric thiamine deficiency disorders in high‐income countries between 2000 and 2020: a clinical reappraisal
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9 hours ago, brian1 said:
I also beleave gluten-free foods deplete the b vitamins in the body and brain it explains a lot of things
Yes, gluten free processed foods are not required by law to be enriched or fortified with essential vitamins lots during processing like gluten based processed foods are.
Plus gluten free processed foods are made with lots of added sugars, and saturated unhealthy fats which require higher doses of Thiamine to turn into energy for our bodies.
Hiding in Plain Sight: Modern Thiamine Deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
Taking additional thiamine (benfotiamine) will help improve constipation and gut motility.
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@brian1, welcome to the forum
Sorry to hear you're not feeling better. Improving one's vitamin levels are so important.
I use Thiamine, Pyridoxine B6, and Cobalamine B12 for pain relief in addition to a B Complex supplement. This combination really works for my pain.
Keep us posted on your progress!
Here's some articles you might find interesting.
High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963161/
And...
Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
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The AIP diet is meant to reduce inflammation and allow healing. If you go back to eating inflammatory foods, the intestines are going to get inflamed again.
Lactose intolerance and a reaction to Casein, a protein in dairy that resembles the protein gluten, can cause continuing inflammation.
Are you eating a nutrient dense diet? Do you eat gluten free processed foods?
Do you take vitamins and minerals? Essential vitamins and minerals can become low in Celiac Disease due to malabsorption and a diet full of empty calories and high fat from gluten free processed foods.
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Yes, much of the damage done in Celiac Disease is microscopic. A pathologist trained in Celiac Disease pathology should be able to recognize it.
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Welcome to the forum, @GardeningForHealth!
I would call what you describe as "Malnutrition Progression" because the gluten free diet can be inadequate in vitamins and minerals.
Additional food sensitivities can be a result of high histamine levels and inadequate vitamins needed to clear histamine.
Following a low histamine AIP diet will help the intestines heal. Nutritional supplementation helps boost your ability to absorb essential nutrients so that the body can function properly and heal.
What supplements are you taking? How often? Doses?
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Remember that twenty percent increase in dietary thiamine causes an eighty percent improvement in brain function? You can be on that borderline between minimum sufficiency and deficiency for a long time, years.
Try a combination of injections and Allithiamine. See how it works for you. I don't see anything problematic there.
Hiding in Plain Sight
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
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Welcome to the forum, @OctiSD!
You may want to consider having an endoscopy with biopsies now without a gluten challenge. That way you could get a baseline of what damage done due to Celiac is still left and needs healing. It can also rule out any other digestive problems that can cause similar symptoms. Checking anti gluten antibodies in the blood would also be a good idea.
Hope this helps.
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This has a list of ingredients...
No gluten, corn starch.
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No, the Erythrocyte Transketolase test is not widely available. One of the labs that offered it closed due to Covid.
The World Health Organization recommends taking high dose Thiamine and looking for symptom improvement.
Different types of Thiamine have different doses. Thiamine Hydrochloride is not well absorbed, so higher amounts are needed for passive diffusion into cells in order to turn transporters back on. Benfotiamine and TTFD are able to penetrate the lipid layer of cells, so lower doses are needed. Everyone is different, so try different combinations and and doses to find what works for you.
Thiamine Hydrochloride 500-2000 mg; Benfotiamine 300-1200 mg; TTFD 200-500 mg.
Thiamine needs magnesium to make important enzymes, so a magnesium glycinate or magnesium threonate supplement is a good idea.
Thiamine interacts with every other B vitamins, so a B Complex supplement should also be taken. It's okay if thiamine HCl is in the B Complex. Take Allithiamine in addition to the B Complex.
Allithiamine can cross the blood brain barrier easily and is excellent for increasing brain function. It's like an already active form of Thiamine the brain can use immediately. Thiamine HCl and Benfotiamine need to be carried across the blood brain barrier. Improvement is seen with any of these forms of Thiamine.
For people who have altered brain function, getting any sort of Thiamine into the system quickly is important to prevent permanent damage. Hence the recommendation to get IV thiamine if possible. Wernicke's Encephalopathy is not fun. For long term supplementation, Allithiamine and Benfotiamine.
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An Erythrocyte Transketolase test is a better method of testing for Thiamine deficiency.
Thiamine deficiency correction needs Thiamine supplementation for longer than a few days.
Thiamine in the form of Tetrahydrofurfuryl Disulfide (TTFD) (aka Allithiamine) can get into the brain easily and improves brain function better than Thiamine Hydrochloride in shots.
Thiamine transporters shut down in deficiency, and blood levels can look normal because little thiamine is getting into cells, so blood levels look normal. The Erythrocyte Transketolase test looks for the reactivity of Thiamine in the bloodstream.
Chronic Thiamine deficiency outside of Alcoholism has different effects on the brain.
Gastrointestinal Beriberi and Wernicke's Encephalopathy Triggered by One Session of Heavy Drinking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739701/
Thresholds and Tipping Points in Thiamine Deficiency Syndromes
https://www.hormonesmatter.com/thresholds-and-tipping-points-in-thiamine-deficiency/
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You may want to keep a food-mood-poo'd diary. Tracking irritating foods is much easier with a diary and helpful to doctors and nutritionists.
Sometimes while healing we can react to other foods. Eggs, soy, and other grains like corn may be difficult to digest and may provoke gastrointestinal symptoms. Lactose intolerance or a reaction to Casein is possible and can cause diarrhea.
Chronic constipation can be a symptom of magnesium and thiamine deficiencies. Supplementation with a B Complex and minerals like magnesium to boost your absorption is beneficial. Discuss checking for deficiencies with your doctor.
Keep us posted on your progress!
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Welcome to the forum, @heyitsme!
Your experiences and symptoms sound similar to mine when I had Thiamine deficiency and other nutritional deficiencies. You can read more of my story in my blog.
Elevated liver enzymes are a symptom of Thiamine deficiency.
Dizziness, especially after changing position could be Postural Orthostatic Tachycardia Syndrome, also caused by Thiamine deficiency. Tachycardia, heart racing or fluttering or skipping beats, is a symptom of Thiamine deficiency.
Brain fog, altered brain function, lack of focus, inability to concentrate, is caused by Thiamine deficiency. Panic attacks are also symptoms of Thiamine deficiency. Thiamine is needed to make important neurotransmitters.
Eye problems can be caused by Thiamine deficiency. Difficulty focusing, blurry vision, and uncontrolled eye movements are seen in Thiamine deficiency.
Thiamine deficiency causes visible changes in the brain. MRIs will show white spots in certain areas of the brain. Brain damage can be permanent if thiamine deficiency is not corrected quickly.
Thiamine and Folate share the same transporters which allow them to get into cells. When there's a Thiamine deficiency, the transporters shut down and neither thiamine nor folate can enter cells. To get the transporters to turn back on, high dose Thiamine is needed.
Blood levels of vitamins may be within "normal" levels, but there can still be a functional deficiency because the vitamins are not getting inside the cells where they are used.
Thiamine deficiency symptoms can wax and wane mysteriously depending upon the amount of Thiamine absorbed from the daily diet. A twenty percent increase in dietary thiamine causes an eighty percent increase in brain function and improvement in symptoms.
Meat is high in Thiamine, so your high meat Paleo diet brought you improvement.
Thiamine needs magnesium to make life sustaining enzymes. Thiamine interacts with the seven other B vitamins and magnesium in producing energy and enzymes needed for cell and organ functions. All eight B vitamins and magnesium need to be taken with high dose Thiamine. Many thiamine deficiency symptoms can overlap with deficiencies in other B vitamins because they all work together. Thiamine is the B vitamin that runs out first because it cannot be stored for long (3 to 18 days) and our body needs so much, especially if we're physically sick, emotionally stressed, or physically active or exercising in hot weather.
High dose Thiamine can be administered by IV by doctors. High dose Thiamine is safe and nontoxic. Unfortunately, doctors don't recognize these varied symptoms of Thiamine deficiency. Most cases of Thiamine deficiency are diagnosed postmortem.
I studied Nutrition before earning a degree in Microbiology, so I understand how vitamins from food are utilized inside the body. I took high dose Thiamine after my doctors gave up on me. I took over-the-counter thiamine supplements to correct my deficiency. I had improvement within an hour. The World Health Organization says that a thiamine deficiency can be diagnosed if health improvements are seen after supplementing with Thiamine.
An Erythrocyte Transketolase test is better at noting a thiamine deficiency.
Thiamine is safe and nontoxic in high doses. No harm, no foul in trying it.
References:
Thiamine deficiency disorders: a clinical perspective
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/
Neuro-ophthalmic Manifestations of Wernicke Encephalopathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335288/
Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039400/
Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316433/
Thresholds and Tipping Points in Thiamine Deficiency Syndromes
https://www.hormonesmatter.com/thresholds-and-tipping-points-in-thiamine-deficiency/
Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet
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I've used Cobalamine B12, Thiamine B1, and Pyridoxine B6 to help with my back pain. These vitamins together are found to act as an analgesic.
Since nutritional deficiencies are common in Celiac Disease, supplementing with vitamins and minerals is a good idea.
Hope this helps!
Role of B vitamins, thiamine, pyridoxine, and cyanocobalamin in back pain and other musculoskeletal conditions: a narrative review
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@KSS1918, welcome to the forum!
Yes, I've experienced tinnitus and difficulty swallowing (dysphagia). My Vitamin D level was very low and I was low in B Complex vitamins, especially Thiamine B1.
Thiamine insufficiency affects the nerves in the head and neck causing dysphagia, tinnitus and hearing loss. Being low in other B vitamins, Riboflavin B2, Niacin B3, and Cobalamine B12, can also influence tinnitus. Too much caffeine and a diet high in carbohydrates can influence tinnitus as well.
Thiamine is not routinely tested. Blood tests for many B vitamins are not an accurate measurement of how well a vitamin is working inside cells. Vitamin deficiency symptoms can occur before there's a low level seen in blood tests. Most thiamine deficiencies are diagnosed postmortem. Thiamine insufficiency needs to be corrected quickly.
The World Health Organization recommends taking high dose Thiamine if a deficiency is suspected. Improvement is seen within hours or a few days.
Doctors are not trained in nutritional deficiencies. Thiamine deficiency symptoms outside of alcoholism are different and many of the symptoms are overlooked.
My thiamine deficiency got very serious. My tinnitus progressed to hearing loss and deafness. I had difficulty swallowing and felt like my throat was closing up. My doctors didn't recognize my symptoms as Thiamine deficiency, although several asked if I drank alcohol. When I insisted I wasn't drinking, they shrugged their shoulders and dismissed me. Sad. I had studied Nutrition before earning a degree in Microbiology, so I knew how vitamins work inside cells. I started high dose Thiamine with over-the-counter thiamine supplements. My symptoms improved within an hour. Thiamine is safe and nontoxic even in high doses. No harm, no foul for taking Thiamine and looking for improvement.
Thiamine interacts with every one of the other seven B vitamins, so a B Complex is needed, as well as magnesium to make enzymes with Thiamine.
The gluten free diet can be low in essential vitamins and minerals. Add to that our poor absorption caused by damage to the villi in the small intestine from Celiac. Supplementation is beneficial in Celiac Disease.
Hope this helps!
References:
Serum Vitamin D Concentration Is Lower in Patients with Tinnitus: A Meta-Analysis of Observational Studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047354/
Acute Bilateral Deafness as the First Symptom of Wernicke Encephalopathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966433/
Therapeutic role of Vitamin B12 in patients of chronic tinnitus: A pilot study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918681/
Relationship Between Diet, Tinnitus, and Hearing Difficulties
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664714/
Hiding in Plain Sight: Modern Thiamine Deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/
Thiamine deficiency disorders: a clinical perspective
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/
Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet
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I like The Paleo Approach by Dr. Sarah Ballantyne.
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Welcome to the forum, @Sammy cat!
Are you consuming green smoothies?
Thiamine supplementation
in Related Issues & Disorders
Posted
@Celiac16,
Thiamine (any form including Benfotiamine) needs magnesium to make life sustaining enzymes. Taking Thiamine without sufficient magnesium means the body cannot use Thiamine properly.
I understand how magnesium can make you feel "knocked out" but that goes away with continued supplementation. When I first started supplementing magnesium, I took it at bedtime, too. Magnesium helps muscles relax, so feeling really knocked out was a sign to me I was deficient. I kept taking it. Magnesium doesn't knock me out anymore since my deficiency was corrected.
Thiamine chelates heavy metals like Lead and Cadmium. Thiamine binds irreversibly with dangerous heavy metals like Lead and Cadmium, so they can be removed from the body through the digestive tract.
Thiamine combines with chromium to form an enzyme. Thiamine and chromium separately both help regulate blood glucose levels and use of insulin. Thiamine and Selenium are both utilized in the thyroid. Enzymes made with manganese are used after thiamine enzymes inside cells.
Thiamine interacts with each of the other B vitamins. Each of the B vitamins is needed at different points in the production of energy for cell metabolism.
You are doing yourself a disservice by not supplementing with the other B vitamins and magnesium as well as Thiamine. Insufficiencies in the other B vitamins can affect how well Thiamine is utilized in the body.
Some people don't like a B Complex supplement because Nicotinic Acid or Niacin Vitamin B 3 causes flushing. Flushing is temporary, and goes away with continued use. I've heard it said, the worse the flush, the more your body needs the niacin. As deficiency levels are corrected, the flushing ceases.
If you don't like B Complex, take each of the eight B vitamins separately.
Vitamins A, D and C are important as well. Vitamin D helps regulate inflammation. Vitamin A and C help in healing.
Have you been referred to a Nutritionist?
References:
Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/
Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019700/
Effects of Combined Dietary Chromium(III) Propionate Complex and Thiamine Supplementation on Insulin Sensitivity, Blood Biochemical Indices, and Mineral Levels in High-Fructose-Fed Rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510416/