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docaz

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Celiac.com - Celiac Disease & Gluten-Free Diet Support Since 1995

Everything posted by docaz

  1. docaz
    Yes, Omission beer is treated with the same endopeptidase that is the main ingredient of GliadinX. You can read on their website that according to existing tests, their gluten content is less than 20ppm but the issue is that the reliability of the testing method that is used to measure how much gluten was removed is not fully validated. I hope that within...
  2. docaz
    Hi, This is exactly how GliadinX should be used. You still have to be cautious but hopefully it alleviates some of the anxiety in any setting that is not completely controlled. At this time, GliadinX is not my primary source of income and in fact it is not profitable yet and the type of experience you have is what makes me very happy. Even if AN...
  3. docaz
    This is exactly the problem. The moment you go to place that has also gluten, your chance of being exposed to gluten is quite high and every study has confirmed this. If you have a family with kids who want to have a social life and spend time with other kids or you have to go to a business meeting or just eating at grandmother's house for a holiday...
  4. docaz
    There might be hope because there is active research. For example, there was a quite extensive and expensive vaccine trial (Nexvax2) but unfortunately, it did not work. There is also a study with monoclonal antibodies that was just recently posted on this site-see below. One of the obstacles to finding a cure is the fact that success and failure take...
  5. docaz
    Are you sure it is a candida infection? In healthy adults, this is extremely rare. It is most commonly seen in people with severe debilitating autoimmune diseases (celiac is not one of them) in extremely young or old people. I would for sure investigate further. Clotrimazole troches are often prescribed and well tolerated for candida infections.
  6. docaz
    At this time, there are no UK distributors and GliadinX can be shipped from the US to the UK. Unfortunately, the shipping costs are a bit expensive ($9) and the shipping time is about 3 weeks. Kind Regards
  7. docaz
    Hi, I have become aware of this thread and I am actually the one who developed the GliadinX formulation because two of my children are celiac. I am in the biotech field and when my children were diagnosed, I did an extensive literature search and found the preliminary studies with AN-PEP and met with Luppo Edens who developed AN-PEP and with Frits...
  8. docaz
    This is obviously something to discuss with your doctor but it is not likely to be celiac. You can also contact the pathologist who looked at the slides. They do not often get that request and depending on the person, she/he might be very happy to speak to you.
  9. docaz
    Usually, a blood test or a breath test is done to identify H. pylori because it is less invasive than a scope but if a scope is done anyway, it can be used for diagnosis. That "lamina propria" information is important because that's where the changes are seen in the mucosa of the intestine. Actually, I mistakenly said in my previous post that there...
  10. docaz
    It is a little unusual to start out with the biopsy before taking blood tests but that's too late now. Especially if the blunting is mild, there is a lot of subjectivity to the histologic findings because it is not really quantified. What one pathologist would evaluate as mild blunting, another one might consider it within normal limits. If the blood tests...
  11. docaz
    Mild blunting by itself is common in gastritis and duodenitis and can have many reasons (see below). It is important to identify the type of infiltrate in the lining. Celiac disease is associated with an increased ratio of neutrophilic infiltrate. An experienced pathologist will easily be able to determine that. Also, if the blunting is caused by celiac disease...
  12. docaz
    This type of situation is actually documented. Here is one paper that describes spontaneous normalization of the blood tests in children with diabetes. https://care.diabetesjournals.org/content/38/11/e188 The previous head of the UofC celiac center mentioned to me that there are rare situations in which celiac patients who ate gluten went into a temporary...
  13. docaz
    It will take some time because the researchers have learned from earlier studies that were too short including a previous study with AN-PEP that showed no difference between placebo and the active product because there was not enough time for the placebo group to deteriorate. The same problem occurred with a latiglutenase study which was conducted for FDA...
  14. docaz
    For all who are wondering if GliadinX is beneficial or not, the answer will be available. One of the most reputable celiac research centers has evaluated the preliminary data and is now conducting a double blind study on 80 patients comparing placebo with GliadinX. The study is well designed and evaluates multiple parameters including residual gluten immunogenic...
  15. docaz
    Here is publication from this month summarizing human and animal studies for various promising ways to address celiac disease including AN-PEP (bottom of page 7), which is the main active component of GliadinX https://www.researchgate.net/publication/348337489_Going_Beyond_Gluten-Free_a_Review_of_Potential_Future_Therapies_for_Celiac_Disease#fullTextFileContent
  16. docaz
    Since you went gluten-free only a short time ago, it might make sense to go back now on gluten and to discuss with your doctor how soon you can schedule the blood tests and biopsy. If you go completely guten-free and then need to start a gluten-challenge again, that might require you to go through agony for a long time. Pancreolan appear pancreatic enzyme...
  17. docaz
    GliadinX was designed for all these situations in which contamination could be present. I encourage all to read the studies that are on the GliadinX website to understand how GliadinX works. It might take a little time but I am convinced that you will find it worth while. On a different note, we have instituted a program for people who are in great...
  18. docaz
    This is not something you have to be concerned about. A one time gluten accident is not enough to cause flattening of the villi in the mucosa that is detectable on the endoscopy (and that's why prior to an endoscopy to diagnose celiac disease, gluten has to be ingested on a regular basis for multiple weeks).
  19. docaz
    This is just a recent paper that describes how enzymes including AN-PEP (the main enzyme in GliadinX) break down the gliadin molecule before it enters the small intestine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530343/ These enzymes do not cure celiac disease because they do not have any systemic effect on the body but what they do is essentially...
  20. docaz
    Indeed, the flow agent maltodextrin that is in GliadinX is potato derived. Sometimes that component is wheat derived but the potato source was chosen (even if the wheat derived option is also considered gluten-free because of the purification) to avoid any concern of gluten contamination. I do not know how common potato allergies are but if someone is allergic...
  21. docaz
    Nasal allergies can absolutely make you dizzy. The organ that controls balance is inside the inner ear which is right next to the middle ear. There is a tube that goes from pharynx to the middle ear that equalizes the pressure between the middle ear and the pharynx. When you are on a plane and are landing after flying at high altitude you feel that pressure...
  22. docaz
    I wonder what makes you think that. Here is a cross-section view that shows the proximity of the nasal cavity to the brain https://www.discovermagazine.com/mind/is-the-human-olfactory-bulb-necessary. The cranial nerve that is responsible for smelling (olfactory bulb) is actually a direct extension of the brain and is separated from the upper nasal cavity...
  23. docaz
    My contribution to this thread is inspired by Dr. Guandalini who is a world renowned expert https://www.uchicagomedicine.org/find-a-physician/physician/stefano-guandalini I have spoken recently to him and his opinion is that biopsies are widely overused in the US because the blood tests are in most situations sufficient. In a situation like this...
  24. docaz
    (I am in a different field but I would not let my patients dangle for a month before discussing a biopsy result and you might be able to speak to your doctor over the phone but still keeping your follow up appointment for a more detailed discussion.) In any case, If the celiac panel was (really) positive, it is very likely that you will have to go on a gluten...
  25. docaz
    Just a few days ago, I happened to talk to Dr. Guandalini, the founder of the University of Chicago Celiac Center (please feel free to do a web-search, who he is) about the recent good test results of my own children and how it relates to GliadinX. He actually performed the endoscopy on one of my children. His opinion is that endoscopy is widely overused...
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